Results 121 to 130 of about 46,677 (295)

Potential Targets Related to Skin Aging: Based on eQTL and GWAS Datasets

Clinical, Cosmetic and Investigational Dermatology
Hanping Shi,1,2 Xianwei Cao1– 3 1School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University,
Shi H, Cao X
doaj  

SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies

BMC Genetics, 2019
Background Over the relatively short history of Genome Wide Association Studies (GWASs), hundreds of GWASs have been published and thousands of disease risk-associated SNPs have been identified.
Ivan Gorlov, Xiangjun Xiao, Maureen Mayes, Olga Gorlova, Christopher Amos   +4 more
doaj   +1 more source

eQTL studies: from bulk tissues to single cells.

Journal of genetics and genomics = Yi chuan xue bao, 2023
Jingfei Zhang, Hongyu Zhao
semanticscholar   +1 more source

A Principled Framework for Mendelian Randomization in Oral Health Research

Journal of Periodontal Research, EarlyView.
This methodological article provides a clear and accessible overview of Mendelian randomization for oral health researchers, emphasizing the core assumptions needed for credible causal inference. Focusing on applications in oral health, particularly periodontitis, it highlights both the strengths and limitations of the study design in order to support ...
Nasir Z. Bashir, Mario Romandini, Moritz Kebschull, Konstantinos K. Tsilidis, Dominique S. Michaud, Stephen Burgess   +5 more
wiley   +1 more source

eQTL Viewer: visualizing how sequence variation affects genome-wide transcription

BMC Bioinformatics, 2007
Background Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expression profiles are related with sequence polymorphisms across the genome ...
Zeng Zhao-Bang, Aylor David L, Zou Wei
doaj   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
core  

Unsupervised empirical Bayesian multiple testing with external covariates

, 2008
In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil, Frigessi, Arnoldo, Kong, Augustine, Rue, Håvard, Thorleifsson, Gudmar   +4 more
core   +2 more sources

Selection for Tameness in Red Junglefowl Recapitulates Genetic Loci Associated With Domestication‐Related Brain Composition

Molecular Ecology, EarlyView.
ABSTRACT Domestication involves huge phenotypic shifts via strong directional selection. The resulting changes, often termed the Domestication Syndrome, typically encompass numerous traits; however, the most universal of these are changes in reduced fear of humans (tameness) and brain composition.
Carlos Guerrero‐Bosagna, Fábio Pértille, Zahra Moradinour, Rebecca Katajama, Maria Luisa Martin Cerezo, Rie Henriksen, Per Jensen, Dominic Wright   +7 more
wiley   +1 more source

A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data.

PLoS Computational Biology, 2020
A longstanding goal of regulatory genetics is to understand how variants in genome sequences lead to changes in gene expression. Here we present a method named Bayesian Annotation Guided eQTL Analysis (BAGEA), a variational Bayes framework to model cis ...
David Lamparter, Rajat Bhatnagar, Katja Hebestreit, T Grant Belgard, Alice Zhang, Victor Hanson-Smith   +5 more
doaj   +1 more source

OrchidMD: An Integrated and User‐Interactive Orchid Multi‐Omics Database for Mining Genes and Biological Research

Plant Biotechnology Journal, EarlyView.
ABSTRACT The Orchidaceae family, with its unparalleled species diversity among angiosperms, is integral to ornamental, medicinal, cultural, and ecological value. Multi‐omics techniques have proven invaluable for the identification of candidate genes and the advancement of functional genomics research. Nevertheless, the application of these technologies
Yonglu Wei, Zengyu Lin, Qi Xie, Jie Gao, Jianpeng Jin, Jie Li, Chuqiao Lu, Guangying Ye, Wenkang Li, Chuanfeng Huang, Dengqi Yang, Qi Liu, Genfa Zhu, Fengxi Yang   +13 more
wiley   +1 more source