Results 161 to 170 of about 46,677 (295)

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment

Cell Genomics
Summary: Most variants identified from genome-wide association studies (GWASs) are non-coding and regulate gene expression. However, many risk loci fail to colocalize with expression quantitative trait loci (eQTLs), potentially due to limited GWAS and ...
Lida Wang, Havell Markus, Dieyi Chen, Siyuan Chen, Fan Zhang, Shuang Gao, Chachrit Khunsriraksakul, Fang Chen, Nancy Olsen, Galen Foulke, Bibo Jiang, Laura Carrel, Dajiang J. Liu   +12 more
doaj   +1 more source

Fast Genome-Wide QTL Analysis Using Mendel

, 2014
Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis.
Hu, Tao, Lange, Kenneth, Sobel, Eric M, Zhou, Hua, Zhou, Jin   +4 more
core  

TreeQTL: hierarchical error control for eQTL findings [PDF]

, 2015
Christine B. Peterson, Marina Bogomolov, Yoav Benjamini, Chiara Sabatti   +3 more
openalex   +1 more source

Shared genes and pathways in dementia: Insights from genome‐wide association studies

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence. Genome‐wide association studies (GWASs), as highlighted in this review, have revolutionized our understanding of dementia by identifying contributing genetic loci and pathways,
Kyle J. Loi, Noah Radtke, Chloe Kiriluk, Mohamed H. Noureldein, Eva L. Feldman, Kelly M. Bakulski, Kevin S. Chen   +6 more
wiley   +1 more source

Integrative multi‐omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder with heterogeneous genetic and molecular underpinnings. Polygenic scores (PGS) capture little of this complexity. METHODS We conducted genome‐, transcriptome‐, and proteome‐wide association studies (G/T/PWAS) on 15,480 individuals from the Alzheimer's Disease ...
Rasika Venkatesh, Katie M. Cardone, Yuki Bradford, Anni K. Moore, Rachit Kumar, Jason H. Moore, Li Shen, Dokyoon Kim, Marylyn D. Ritchie   +8 more
wiley   +1 more source

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism‐related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Our previous work established the AD‐BXD mouse panel as an innovative model for studying the genetic complexity and heterogeneity underlying Alzheimer's disease (AD). In this study, we leveraged this model and proteomics approach to identify protein signatures linked to cognitive resilience in AD.
Yu Chen, Tamara K. Stevenson, Yiding Cao, Lauren A. Fish, Julia E. Robbins, Gennifer E. Merrihew, Jea Park, Timothy J. Hohman, Michael J. MacCoss, Catherine C. Kaczorowski   +9 more
wiley   +1 more source

Alzheimer's disease multi‐ancestry genome‐wide interaction and stratified study with smoking

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) has genetic and environmental risk factors, including cigarette smoking. Gene–environment interactions may explain AD missing heritability. METHODS Lifetime smoking data from 22,032 European ancestry and 3126 African ancestry participants from the Alzheimer's Disease Genetic Consortium and the Framingham ...
Ryan Dacey, Lei Hou, Ashita Gurnani, Xudong Han, Mackenzie R. Paller‐Moore, Jaeyoon Chung, Shruti Durape, Max Rosenthaler, Madeline Uretsky, Bobak Abdolmohammadi, Annie J. Lee, Adam M. Brickman, Timothy J. Hohman, Michael L. Cuccaro, David A. Bennett, Paul K. Crane, M. Ilyas Kamboh, Walter A. Kukull, Gyungah Jun, Thor D. Stein, Ann C. McKee, Jonathan L. Haines, Margaret A. Pericak‐Vance, Li‐San Wang, Gerard D. Schellenberg, Richard Mayeux, Kathryn L. Lunetta, Lindsay A. Farrer, Jesse Mez   +28 more
wiley   +1 more source

Scalable eQTL mapping using single-nucleus RNA-sequencing of recombined gametes from a small number of individuals.

PLoS Biology
Phenotypic differences between individuals of a species are often caused by differences in gene expression, which are in turn caused by genetic variation.
Matthew T Parker, Samija Amar, José A Campoy, Kristin Krause, Sergio Tusso, Magdalena Marek, Bruno Huettel, Korbinian Schneeberger   +7 more
doaj   +1 more source

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

Brain and Behavior, Volume 15, Issue 11, November 2025.
GI and ND GWAS and blood eQTL data were analyzed using LDSC, HDL, LAVA, GPA, PLACO, FUMA, MAGMA, SMR, HEIDI, and two‐sample MR to assess genetic correlations, pleiotropy, functional annotation, shared gene expression, and causal relationships. ABSTRACT Background This study investigates the shared genetic basis between gastrointestinal (GI) diseases ...
Yan Jiang, Yuxiang Zhang, Lei Ma, Chao Li   +3 more
wiley   +1 more source

Joint analyses of multi-tissue Hi-C and eQTL data demonstrate close spatial proximity between eQTLs and their target genes [PDF]

, 2019
Jingting Yu, Ming Hu, Chun Li
openalex   +1 more source