Results 171 to 180 of about 46,677 (295)

Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches

Brain and Behavior, Volume 15, Issue 11, November 2025.
To systematically identify risk medications for migraine and its subtypes, we integrated GWAS data for 23 medications with GWASs of migraine and its subtypes to conduct causal inference. We then combined plasma eQTLs with drug‐target databases to map putative targets of the risk medications and validated causal relationships using colocalization and ...
Nan Wang, Weixuan Liang, Zhuofeng Wen, Wanzhe Liao, Zhixin Xie, Zhiyi Zhou, Ziyang Yang, Xitong Ju, Haobin Zhou, Chuiguo Huang   +9 more
wiley   +1 more source

Genome‐Wide Meta‐Analysis of Parkinson's Disease Associated Genetic Loci and Validation of Therapeutic Targets

Brain and Behavior, Volume 15, Issue 11, November 2025.
This study identified genetic loci associated with Parkinson's disease through a genome‐wide meta‐analysis, screened druggable genes significantly linked to PD risk, and assessed the potential of GCLC and GFPT1 as therapeutic targets. ABSTRACT Background To identify genetic loci associated with Parkinson's disease (PD) through a genome‐wide meta ...
Shan Yang, Qinfen Wu, Xinling Yang
wiley   +1 more source

Association of Germline Single Nucleotide Polymorphisms in Steroid Hormone Metabolism Pathway With Androgen Deprivation Therapy Prognosis of Prostate Cancer in Chinese Population

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Single nucleotide polymorphisms (SNPs) located in the genes participating in the steroid hormone metabolism pathway may influence the outcomes of androgen deprivation therapy (ADT) in prostate cancer (PCa) patients, but findings on the Chinese population remain limited.
Ruofan Shi, Xiaohao Ruan, Qijun Du, Tsun Tsun Stacia Chun, Da Huang, Kuen Chan, Yuguang Philip Wu, Tsz Yeung Kam, Danfeng Xu, Rong Na   +9 more
wiley   +1 more source

Unraveling effects of lung function GWAS candidates using airway epithelial eQTLs

, 2017
Alen Faiz, Marijn Berg, Cornelis J. Vermeulen, Nick ten Hacken, Wim Timens, Corry‐Anke Brandsma, Gerard H. Koppelman, Irene H. Heijink, Maarten van den Berge   +8 more
openalex   +1 more source

Immune cell–specific eQTLs [PDF]

, 2014
Orli Bahcall
openalex   +1 more source

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Additional file 2 of Limited evidence for blood eQTLs in human sexual dimorphism

, 2022
Eleonora Porcu, Annique Claringbould, Antoine Weihs, Kaido Lepik, Tom G. Richardson, Uwe Völker, Federico Santoni, Alexander Teumer, Lude Franke, Alexandre Reymond, Zoltán Kutalik   +10 more
openalex   +1 more source

Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Using two‐sample Mendelian randomization and bioinformatics, this study found metformin associated with reduced primary liver cancer (PLC) risk (p = 0.026), without links to HCC/ICC. Key genes (e.g., DDX52, KIF11) and pathways (cGMP‐PKG signaling, fatty acid metabolism) were identified.
Yongxin Ma, Jiaojiao Qi, Zhiqiang Chen, Yubo Zhang, Kejun Liu, Jiaxin Suo, Bendong Chen, Yang Bu   +7 more
wiley   +1 more source

Integrated Multiomics Analysis and Mendelian Randomization Identify SIRT1 as a Pivotal Aging‐Associated Gene in Meningioma

IUBMB Life, Volume 77, Issue 11, November 2025.
ABSTRACT Meningiomas (MGMs) are the most prevalent benign intracranial tumors in adults, with incidence markedly increasing with age, underscoring the need to explore aging‐associated molecular mechanisms. In this study, we integrated transcriptomic datasets (GSE43290, GSE54934, GSE77259, and GSE183655) from the GEO database and aging‐related genes ...
Guangyu Du, Daikang Xu, Jingxian Sun, Shusheng Che, Junwei Ma, Xiaolei Lan, Jianpeng Wang, Zhiyong Yan   +7 more
wiley   +1 more source

A trans-eQTL network regulates osteoclast multinucleation and bone mass [PDF]

, 2020
Marie Pereira, Jeong‐Hun Ko, John G. Logan, Hayley Protheroe, Kee‐Beom Kim, Amelia L.M. Tan, Kwon-Sik Park, Maxime Rotival, Enrico Petretto, J. H. Duncan Bassett, Graham R. Williams, Jacques Behmoaras   +11 more
openalex   +1 more source