Results 231 to 240 of about 48,393 (270)

Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art. [PDF]

Genet Epidemiol
Patasova K, Sedaghati-Khayat B, Knevel R, Cordell HJ, Pratt AG.   +4 more
europepmc   +1 more source

Causal cross-trait mapping at single-cell resolution identifies shared immunogenetic drivers of migraine and Meniere's disease. [PDF]

J Headache Pain
Hu X, Wang Y, Yu SJ, Pan CY, Liang BY, Jiang SS, Chen SW, Han YX.   +7 more
europepmc   +1 more source

Mitochondria-Related Gene BDH1 Implicated in Myopia Risk via Methylation-Regulated Expression: An Integrative Summary-Data Mendelian Randomization Study. [PDF]

Transl Vis Sci Technol
Peng S, Deng H, Tao Z, Chen J, Kang Z.
europepmc   +1 more source

Autophagic molecular network in IS pathogenesis: A multi-omics Mendelian randomization study. [PDF]

Medicine (Baltimore)
Nie H, Zhang L, Hei Y, Ma T, Xu X, Zhang M.   +5 more
europepmc   +1 more source

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Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

American Journal of Human Genetics
Understanding the molecular mechanisms of complex traits is essential for developing targeted interventions. We analyzed liver expression quantitative-trait locus (eQTL) meta-analysis data on 1,183 participants to identify conditionally distinct signals.
Jonathan D Rosen, Yi-Hui Zhou, Karen L Mohlke   +2 more
exaly   +2 more sources

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

Nature Genetics
Julia S El-Sayed Moustafa, Heather M Stringham, Narisu Narisu   +2 more
exaly   +2 more sources

Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease

Science, 2022
The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing (scRNA-seq) data from 1,267,758 peripheral blood mononuclear cells from 982 ...
S. Yazar, José Alquicira-Hernández, Kristof Wing, A. Senabouth, M. Gordon, S. Andersen, Qinyi Lu, Antonia Rowson, Thomas R. P. Taylor, Linda Clarke, Katia Maccora, Christine Y. Chen, A. Cook, Chun Jimmie Ye, K. Fairfax, A. Hewitt, J. Powell   +16 more
semanticscholar   +1 more source

eQTL

2012
The goal of mapping expression quantitative trait loci (eQTLs) is to identify genomic regions regulating gene expression traits, which can be gathered through microarrays, RNA-Seq, or related methods. Because thousands of expression traits are analyzed simultaneously, eQTL analysis can help elucidate regulatory networks and provide valuable insights ...
Lun, Li, Xianghua, Zhang, Hongyu, Zhao
openaire   +2 more sources