Results 31 to 40 of about 40,172 (233)

Expression quantitative trait loci (eQTL) mapping in Puerto Rican children. [PDF]

PLoS ONE, 2015
Expression quantitative trait loci (eQTL) have been identified using tissue or cell samples from diverse human populations, thus enhancing our understanding of regulation of gene expression.
Wei Chen, John M Brehm, Jerome Lin, Ting Wang, Erick Forno, Edna Acosta-Pérez, Nadia Boutaoui, Glorisa Canino, Juan C Celedón   +8 more
doaj   +1 more source

kruX: matrix-based non-parametric eQTL discovery [PDF]

BMC Bioinformatics, 2014
The Kruskal-Wallis test is a popular non-parametric statistical test for identifying expression quantitative trait loci (eQTLs) from genome-wide data due to its robustness against variations in the underlying genetic model and expression trait distribution, but testing billions of marker-trait combinations one-by-one can become computationally ...
Qi, Jianlong, Asl, Hassan, Björkegren, Johan L. M., Michoel, Tom   +3 more
openaire   +5 more sources

CoMM-S4: A Collaborative Mixed Model Using Summary-Level eQTL and GWAS Datasets in Transcriptome-Wide Association Studies

Frontiers in Genetics, 2021
Motivation: Genome-wide association studies (GWAS) have achieved remarkable success in identifying SNP-trait associations in the last decade. However, it is challenging to identify the mechanisms that connect the genetic variants with complex traits as ...
Yi Yang, Kar-Fu Yeung, Jin Liu
doaj   +1 more source

Cell Specific eQTL Analysis without Sorting Cells [PDF]

PLOS Genetics, 2015
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not always be available.
Westra, Harm-Jan, Arends, Danny, Peters, Marjolein J., Schurmann, Claudia, Schramm, Katharina, Kettunen, Johannes, Yaghootkar, Hanieh, Fairfax, Benjamin P., Andiappan, Anand Kumar, Li, Yang, Fu, Jingyuan, Karjalainen, Juha, Platteel, Mathieu, Visschedijk, Marijn, Weersma, Rinse K., Kasela, Silva, Milani, Lili, Tserel, Liina, Peterson, Pärt, Reinmaa, Eva, Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, Homuth, Georg, Petersmann, Astrid, Lorbeer, Roberto, Prokisch, Holger, Meitinger, Thomas, Herder, Christian, Roden, Michael, Grallert, Harald, Ripatti, Samuli, Perola, Markus, Wood, Andrew R., Melzer, David, Ferrucci, Luigi, Singleton, Andrew B., Hernandez, Dena G., Knight, Julian C., Melchiotti, Rossella, Lee, Bernett, Poidinger, Michael, Zolezzi, Francesca, Larbi, Anis, Wang, De Yun, van den Berg, Leonard H., Veldink, Jan H., Rotzschke, Olaf, Makino, Seiko, Salomaa, Veikko, Strauch, Konstantin, Völker, Uwe, van Meurs, Joyce B. J., Metspalu, Andres, Wijmenga, Cisca, Jansen, Ritsert C., Franke, Lude, Esko, Tõnu   +57 more
openaire   +12 more sources

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci.

PLoS Computational Biology, 2017
Genome-wide expression Quantitative Trait Loci (eQTL) studies in humans have provided numerous insights into the genetics of both gene expression and complex diseases.
Jin Hyun Ju, Sushila A Shenoy, Ronald G Crystal, Jason G Mezey   +3 more
doaj   +1 more source

eqtl

, 2022
eqtl ...
openaire   +1 more source

Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. [PDF]

PLoS ONE, 2011
BACKGROUND: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants.
Juan Pedro Steibel, Ronald O Bates, Guilherme J M Rosa, Robert J Tempelman, Valencia D Rilington, Ashok Ragavendran, Nancy E Raney, Antonio Marcos Ramos, Fernando F Cardoso, David B Edwards, Catherine W Ernst   +10 more
doaj   +1 more source

eQTL Mapping Using RNA-seq Data [PDF]

Statistics in Biosciences, 2012
As RNA-seq is replacing gene expression microarrays to assess genome-wide transcription abundance, gene expression Quantitative Trait Locus (eQTL) studies using RNA-seq have emerged. RNA-seq delivers two novel features that are important for eQTL studies.
Wei, Sun, Yijuan, Hu
openaire   +2 more sources

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms [PDF]

, 2017
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await ...
A Schröder, Abdulla al Shafi Majumder, Adam S Butterworth, Alex P Reiner, Anders Malarstig, Andrew D Johnson, Anne Justice, Anne Tybjærg-Hansen, AP Levy, AP Morris, AP Reiner, Arshed A Quyyumi, Asif Rasheed, AV Segrè, Benjamin B Sun, BF Voight, BL Harry, BP Fairfax, Børge G Nordestgaard, C Moore, Cara L Carty, Carl J Pepine, Chao A Hsiung, Charles Kooperberg, CJ Willer, D Qu, Daniel F Freitag, Daniel J Rader, Daniel R Barnes, Danish Saleheen, Devin Absher, Dewan S Alam, Dirk S Paul, DM Greenawalt, E Grundberg, EE Schadt, Elias L Salfati, Emanuele Di Angelantonio, Eric B Fauman, Eric Boerwinkle, F Innocenti, GA Roth, GR Abecasis, H Kirsten, H Lin, H Schunkert, Heribert Schunkert, HJ Westra, Hugh Watkins, I Holme, I-Te Lee, J Chen, J Dennis, J Erdmann, J Ernst, J Ernst, J Yang, Jeanette Erdmann, Jemma B Wilk, Jerome I Rotter, Joanna M M Howson, John A Spertus, John D Eicher, John Danesh, JR Privratsky, JR Staley, Julie A Johnson, Jyh-Ming J Juang, Kari E North, Katrine L Rasmussen, Kent D Taylor, Kristin Young, LD Ward, Lindsay L Waite, LM Boettger, Lucia A Hindorff, M Arnold, M Narahara, M Uhlen, M Uhlén, Mariaelisa Graff, N Franceschini, Nilesh J Samani, NJ Samani, NL Smith, Nora Franceschini, O Franzén, P Surendran, P Zanoni, Panos Deloukas, Philippe Frossard, Pia R Kamstrup, Praveen Surendran, R Goel, Rajiv Chowdhury, Ren-Hua Chung, Robin Young, Ron Do, S Purcell, Sekar Kathiresan, Stanley L Hazen, Steven Buyske, Sune F Nielsen, T Lappalainen, T Zeller, Themistocles L Assimes, Thomas Quertermous, TL Assimes, TM Teslovich, Tzung-Dau Wang, Ulrike Peters, V Nanda, W Tang, Wayne H H Sheu, Weang-Kee Ho, Wei Zhao, Wei-Yu Lin, Wen-Jane Lee, WJ Astle, X Zhang, X Zhou, Xiuqing Guo, Yi-Jen Hung, Yii-Der Ida Chen, Ying-Hsiang Chen, Z Wang, Å Johansson   +126 more
core   +2 more sources

Fast eQTL Analysis for Twin Studies [PDF]

Genetic Epidemiology, 2015
ABSTRACTTwin data are commonly used for studying complex psychiatric disorders, and mixed effects models are one of the most popular tools for modeling dependence structures between twin pairs. However, for eQTL (expression quantitative trait loci) data where associations between thousands of transcripts and millions of single nucleotide polymorphisms ...
Zhaoyu, Yin, Kai, Xia, Wonil, Chung, Patrick F, Sullivan, Fei, Zou   +4 more
openaire   +2 more sources