Results 31 to 40 of about 41,400 (238)

Association between Expression Quantitative Trait Loci and Metabolic Traits in Two Korean Populations.

PLoS ONE, 2014
Most genome-wide association studies consider genes that are located closest to single nucleotide polymorphisms (SNPs) that are highly significant for those studies.
Kyung-Won Hong, Seok Won Jeong, Myungguen Chung, Seong Beom Cho   +3 more
doaj   +1 more source

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues

BMC Bioinformatics, 2018
Background Expression quantitative trait loci (eQTL) analysis identifies genetic markers associated with the expression of a gene. Most existing eQTL analyses and methods investigate association in a single, readily available tissue, such as blood. Joint
Gen Li, Dereje Jima, Fred A. Wright, Andrew B. Nobel   +3 more
doaj   +1 more source

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms [PDF]

, 2017
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await ...
A Schröder, Abdulla al Shafi Majumder, Adam S Butterworth, Alex P Reiner, Anders Malarstig, Andrew D Johnson, Anne Justice, Anne Tybjærg-Hansen, AP Levy, AP Morris, AP Reiner, Arshed A Quyyumi, Asif Rasheed, AV Segrè, Benjamin B Sun, BF Voight, BL Harry, BP Fairfax, Børge G Nordestgaard, C Moore, Cara L Carty, Carl J Pepine, Chao A Hsiung, Charles Kooperberg, CJ Willer, D Qu, Daniel F Freitag, Daniel J Rader, Daniel R Barnes, Danish Saleheen, Devin Absher, Dewan S Alam, Dirk S Paul, DM Greenawalt, E Grundberg, EE Schadt, Elias L Salfati, Emanuele Di Angelantonio, Eric B Fauman, Eric Boerwinkle, F Innocenti, GA Roth, GR Abecasis, H Kirsten, H Lin, H Schunkert, Heribert Schunkert, HJ Westra, Hugh Watkins, I Holme, I-Te Lee, J Chen, J Dennis, J Erdmann, J Ernst, J Ernst, J Yang, Jeanette Erdmann, Jemma B Wilk, Jerome I Rotter, Joanna M M Howson, John A Spertus, John D Eicher, John Danesh, JR Privratsky, JR Staley, Julie A Johnson, Jyh-Ming J Juang, Kari E North, Katrine L Rasmussen, Kent D Taylor, Kristin Young, LD Ward, Lindsay L Waite, LM Boettger, Lucia A Hindorff, M Arnold, M Narahara, M Uhlen, M Uhlén, Mariaelisa Graff, N Franceschini, Nilesh J Samani, NJ Samani, NL Smith, Nora Franceschini, O Franzén, P Surendran, P Zanoni, Panos Deloukas, Philippe Frossard, Pia R Kamstrup, Praveen Surendran, R Goel, Rajiv Chowdhury, Ren-Hua Chung, Robin Young, Ron Do, S Purcell, Sekar Kathiresan, Stanley L Hazen, Steven Buyske, Sune F Nielsen, T Lappalainen, T Zeller, Themistocles L Assimes, Thomas Quertermous, TL Assimes, TM Teslovich, Tzung-Dau Wang, Ulrike Peters, V Nanda, W Tang, Wayne H H Sheu, Weang-Kee Ho, Wei Zhao, Wei-Yu Lin, Wen-Jane Lee, WJ Astle, X Zhang, X Zhou, Xiuqing Guo, Yi-Jen Hung, Yii-Der Ida Chen, Ying-Hsiang Chen, Z Wang, Å Johansson   +126 more
core   +2 more sources

Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans

BMC Genomics, 2017
Background Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel complex phenotypes through changes in gene expression.
Basten L. Snoek, Mark G. Sterken, Roel P. J. Bevers, Rita J. M. Volkers, Arjen van’t Hof, Rachel Brenchley, Joost A. G. Riksen, Andrew Cossins, Jan E. Kammenga   +8 more
doaj   +1 more source

Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle

BMC Genomics, 2018
Background The mutations changing the expression level of a gene, or expression quantitative trait loci (eQTL), can be identified by testing the association between genetic variants and gene expression in multiple individuals (eQTL mapping), or by ...
Majid Khansefid, Jennie E. Pryce, Sunduimijid Bolormaa, Yizhou Chen, Catriona A. Millen, Amanda J. Chamberlain, Christy J. Vander Jagt, Michael E. Goddard   +7 more
doaj   +1 more source

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

Nature Communications, 2023
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko, Noha Lim, Laura A. Cooney, Kristina M. Harris, Mark S. Anderson, David A. Fox, Dawn E. Smilek, James G. Krueger, Soumya Raychaudhuri   +12 more
doaj   +1 more source

Mapping the genetic architecture of gene expression in human liver [PDF]

, 2008
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits.
Avila-Campillo, I, Chudin, E, Derry, J, Drake, TA, Guengerich, FP, GuhaThakurta, D, Hao, K, Johnson, JM, Kasarskis, A, Kruger, MJ, Lamb, J, Lum, PY, Lusis, AJ, Mehrabian, M, Millstein, J, Molony, C, Rohl, CA, Rushmore, TH, Schadt, EE, Schuetz, E, Sieberts, S, Smith, RC, Storey, JD, Strom, SC, Suver, C, Ulrich, R, Van Nas, A, Wang, S, Yang, X, Zhang, B, Zhu, J   +30 more
core   +3 more sources

Novel Functional eQTL-SNPs Associated With Susceptibility to Mycoplasma pneumoniae Pneumonia in Children

Frontiers in Public Health, 2022
BackgroundThe functional causal single-nucleotide polymorphisms (SNPs) associated with susceptibility to Mycoplasma pneumoniae Pneumonia (MPP) have scarcely been identified.
Yang Dong, Yanmin Gao, Cheng Luo, Nengshun Wu, Zhounan Cheng, Anni Qiu, Yan Zhou, Wendi Zhang, Minjie Chu, Qing Chang   +9 more
doaj   +1 more source

An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

BMC Bioinformatics, 2022
Background A genome-wide association study (GWAS) correlates variation in the genotype with variation in the phenotype across a cohort, but the causal gene mediating that impact is often unclear.
Eric B. Fauman, Craig Hyde
doaj   +1 more source