Results 41 to 50 of about 40,172 (233)
PLoS ONE, 2014 Most genome-wide association studies consider genes that are located closest to single nucleotide polymorphisms (SNPs) that are highly significant for those studies.
Kyung-Won Hong +3 more
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HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues
BMC Bioinformatics, 2018 Background Expression quantitative trait loci (eQTL) analysis identifies genetic markers associated with the expression of a gene. Most existing eQTL analyses and methods investigate association in a single, readily available tissue, such as blood. Joint
Gen Li +3 more
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Inference of modules associated to eQTLs [PDF]
Nucleic Acids Research, 2012 Cataloging the association of transcripts to genetic variants in recent years holds the promise for functional dissection of regulatory structure of human transcription. Here, we present a novel approach, which aims at elucidating the joint relationships between transcripts and single-nucleotide polymorphisms (SNPs). This entails detection and analysis
Kreimer, Anat +5 more
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Methylation-eQTL analysis in cancer research
Bioinformatics, 2021 AbstractMotivationDNA methylation is a key epigenetic factor regulating gene expression. While promoter methylation has been well studied, recent publications have revealed that functionally important methylation also occurs in intergenic and distal regions, and varies across genes and tissue types.
Yusha Liu +12 more
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Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans
BMC Genomics, 2017 Background Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel complex phenotypes through changes in gene expression.
Basten L. Snoek +8 more
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Bipartite Community Structure of eQTLs
PLOS Computational Biology, 2016 Genome Wide Association Studies (GWAS) and eQTL analyses have produced a large and growing number of genetic associations linked to a wide range of human phenotypes. As of 2013, there were more than 11,000 SNPs associated with a trait as reported in the NHGRI GWAS Catalog.
John Platig +3 more
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A geometric interpretation of the permutation $p$-value and its application in eQTL studies [PDF]
, 2010 Permutation $p$-values have been widely used to assess the significance of linkage or association in genetic studies. However, the application in large-scale studies is hindered by a heavy computational burden.
Sun, Wei, Wright, Fred A.
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BMC Genomics, 2018 Background The mutations changing the expression level of a gene, or expression quantitative trait loci (eQTL), can be identified by testing the association between genetic variants and gene expression in multiple individuals (eQTL mapping), or by ...
Majid Khansefid +7 more
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Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
Nature Communications, 2023 Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao +12 more
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Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]
, 2019 Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A. +34 more
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