Results 51 to 60 of about 46,677 (295)

Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle

BMC Genomics, 2018
Background The mutations changing the expression level of a gene, or expression quantitative trait loci (eQTL), can be identified by testing the association between genetic variants and gene expression in multiple individuals (eQTL mapping), or by ...
Majid Khansefid, Jennie E. Pryce, Sunduimijid Bolormaa, Yizhou Chen, Catriona A. Millen, Amanda J. Chamberlain, Christy J. Vander Jagt, Michael E. Goddard   +7 more
doaj   +1 more source

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

Nature Communications, 2023
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko, Noha Lim, Laura A. Cooney, Kristina M. Harris, Mark S. Anderson, David A. Fox, Dawn E. Smilek, James G. Krueger, Soumya Raychaudhuri   +12 more
doaj   +1 more source

eQTL Catalogue: a compendium of uniformly processed human gene expression and splicing QTLs

bioRxiv, 2020
An increasing number of gene expression quantitative trait locus (eQTL) studies have made summary statistics publicly available, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and colocalisation ...
N. Kerimov, J. Hayhurst, Kateryna Peikova, J. Manning, P. Walter, Liis Kolberg, Marija Samoviča, M. P. Sakthivel, I. Kuzmin, S. Trevanion, Tony Burdett, S. Jupp, H. Parkinson, I. Papatheodorou, Andrew D. Yates, D. Zerbino, Kaur Alasoo   +16 more
semanticscholar   +1 more source

An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

BMC Bioinformatics, 2022
Background A genome-wide association study (GWAS) correlates variation in the genotype with variation in the phenotype across a cohort, but the causal gene mediating that impact is often unclear.
Eric B. Fauman, Craig Hyde
doaj   +1 more source

Novel Functional eQTL-SNPs Associated With Susceptibility to Mycoplasma pneumoniae Pneumonia in Children

Frontiers in Public Health, 2022
BackgroundThe functional causal single-nucleotide polymorphisms (SNPs) associated with susceptibility to Mycoplasma pneumoniae Pneumonia (MPP) have scarcely been identified.
Yang Dong, Yanmin Gao, Cheng Luo, Nengshun Wu, Zhounan Cheng, Anni Qiu, Yan Zhou, Wendi Zhang, Minjie Chu, Qing Chang   +9 more
doaj   +1 more source

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [PDF]

, 2014
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.
A Kong, A Lomniczi, A Murphy, A Schröder, AA D’Aloisio, Aarno Palotie, AB Migliano, Adamo Pio D’adamo, Aida K. Dieffenbach, AL Dixon, Albert Hofman, Albert V. Smith, Albertine J. Oldehinkel, Alexander Teumer, Alison M. Dunning, Andrea D. Coviello, Andrea Ganna, Andres Metspalu, Andrew C. Heath, Andrew D. Johnson, André G. Uitterlinden, Angela Cox, Anja Rudolph, Anna M. Storniolo, Anna Murray, Anneli Pouta, Annika Lindblom, Antonietta Robino, AP Abreu, Arto Mannermaa, AS Dimas, AV Segrè, B Kabakchiev, B Zhang, BE Stranger, Behrooz Z. Alizadeh, Ben A. Oostra, Bernardo Bonanni, Bjarke Feenstra, BP Fairfax, Bruce H. R. Wolffenbuttel, C Colantuoni, C Liu, C-J Partsch, Carl Blomqvist, Catharina A. Hartman, Cathy E. Elks, CE Elks, Christian Gieger, Chunyan He, CJ Willer, Cornelia M. van Duijn, CP Schaaf, Craig E. Pennell, D Mehta, D Sasayama, DA Cusanovich, Daniel F. Gudbjartsson, Daniel I. Chasman, Daniel L. Koller, David Couper, David J. Hunter, David Karasik, David P. Strachan, David Schlessinger, Debbie Lawlor, Deborah J. Thompson, Diana L. Cousminer, Dieter Flesch-Janys, Diether Lambrechts, Dirkje S. Postma, DM Greenawalt, Doris Stöckl, Dorret I. Boomsma, Douglas F. Easton, Douglas P. Kiel, E Grundberg, E Grundberg, E Grundberg, Eco E. J. de Geus, EE Schadt, EK Speliotes, EL Heinzen, Eleonora Porcu, Elisabeth Widen, Elizabeth A. Streeten, Ellen A. Nohr, Ellen W. Demerath, Emmi Tikkanen, Enda M. Byrne, Eric Boerwinkle, Erik Ingelsson, Erin K. Wagner, Eva Albrecht, Evelin Mihailov, F Innocenti, F Nagl, F Zou, Felix Day, Femke Atsma, Fergus J. Couch, Fernando Rivadeneira, Frank B. Hu, Frank Geller, GA Heap, George Davey Smith, George McMahon, Georgia Chenevix-Trench, Gerard Waeber, Gisli Masson, Gonneke Willemsen, Graham G. Giles, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, H Lango Allen, H-J Westra, Harold Snieder, Heather A. Boyd, Heli Nevanlinna, Henri Wallaschofski, Henrik Flyger, Henry Völzke, Hermann Brenner, HHH Göring, Hiltrud Brauch, Hoda Anton-Culver, IK Temple, Ilja M. Nolte, Immaculata De Vivo, Irene L. Andrulis, J Ding, J Huang, J Yang, J Yang, J Yang, J. Margriet Collée, JA Webster, Javier Benitez, JC Barrett, Jenny A. Visser, Jenny Chang-Claude, JF Degner, Jing Hua Zhao, Jinhui Chen, Joanne M. Murabito, Joe Dennis, Johan G. Eriksson, John L. Hopper, John P. Rice, John R. B. Perry, Jonathan Tyrer, Jouke-Jan Hottenga, JR Gibbs, Julia A. Knight, Julian Peto, Julie E. Buring, K Estrada, K Hao, K Michailidou, Kamila Czene, Kari Stefansson, Kathryn L. Lunetta, Katri Pylkäs, Kay-Tee Khaw, Ken K. Ong, KS Kompass, Kyriaki Michailidou, L Liang, Laura Crisponi, Laura J. Bierut, Laura M. Yerges-Armstrong, Lavinia Paternoster, LB Barreiro, LFG Silveira, Lili Milani, Lisette Stolk, Lude Franke, Luigi Ferrucci, Lynda M. Rose, M Horikoshi, M Rantalainen, Maartje J. Hooning, Mads Melbye, Manjeet K. Bolla, Marek Zygmunt, Margaret J. Wright, Marjanka K. Schmidt, Marjo-Riitta Järvelin, Mark I. McCarthy, Massimo Mangino, Matthias W. Beckmann, Meir J. Stampfer, Melanie Waldenberger, Melissa E. Garcia, Mellissa C. Southey, Michael J. Econs, Montserrat García-Closas, Munro Peacock, N Ruf, Najaf Amin, Nancy L. Pedersen, Natalia Tšernikova, Nicholas G. Martin, Nicholas J. Timpson, Nicholas J. Wareham, Nora Franceschini, P Prentice, Paolo Gasparini, Paolo Peterlongo, Paolo Radice, Pascal Guénel, Patrick F. McArdle, Patrick Neven, Patrick Sulem, Patrik K. Magnusson, Paul D. P. Pharoah, Paul M. Ridker, Per Hall, Peter A. Fasching, Peter Devilee, Peter Kraft, Peter Vollenweider, Q Li, Qin Wang, Reedik Mägi, Robert Winqvist, Robin Haring, Roger L. Milne, RP Grinspon, RS Huang, RSN Fehrmann, Ruth J. F. Loos, S Cho, S Constantin, S Sulzbacher, Sandra Lai, Sanela Kjellqvist, SE Parker, Serena Sanna, Sheila Ulivi, Stefania Bandinelli, Stephen Chanock, Stig E. Bojesen, Suiqun Guo, Susan Ring, Sven Bergmann, T Kwan, T Maeda, T Zeller, Tamara B. Harris, Tanguy Corre, Tatiana Foroud, Teresa Ferreira, Thorkild I. A. Sørensen, Tim D. Spector, Tune H. Pers, Tõnu Esko, Ulla Sovio, Unnur Thorsteinsdottir, Ute Hamann, V Emilsson, Veikko Salomaa, Veli-Matti Kosma, Vilmundur Gudnason, W Zheng, Wei Q. Ang, Wendy L. McArdle, Y Idaghdour, Y Stelzer, Z Zadik, Zoltan Kutalik   +271 more
core   +7 more sources

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

bioRxiv, 2020
Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies.
Drew R. Neavin, Q. Nguyen, Maciej S Daniszewski, Helena H. Liang, H. Chiu, Y. K. Wee, A. Senabouth, S. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, J. Vickers, A. Cook, N. Palpant, A. Pébay, A. Hewitt, J. Powell   +16 more
semanticscholar   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Causal Associations Between Smoking, Brain Structural Alterations and Psychiatric Disorders: Evidence From a Mediation Analysis. [PDF]

Addict Biol
This study establishes smoking as a causal risk factor for schizophrenia, major depression and bipolar disorder using genetic evidence. We identified microstructural disorganization in the left uncinate fasciculus, a key corticolimbic white matter tract, as a significant mediator of this risk, explaining 19.6% of the effect on depression.
Chen Y, Ma X, Yin Y, Wu Y, Huang Y, Tang Y, Liu S, Ma Q, Wei M, Zhang M, Tao S, Xie M, Deng R, Li M, Wang Q.   +14 more
europepmc   +2 more sources

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms [PDF]

, 2017
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await ...
A Schröder, Abdulla al Shafi Majumder, Adam S Butterworth, Alex P Reiner, Anders Malarstig, Andrew D Johnson, Anne Justice, Anne Tybjærg-Hansen, AP Levy, AP Morris, AP Reiner, Arshed A Quyyumi, Asif Rasheed, AV Segrè, Benjamin B Sun, BF Voight, BL Harry, BP Fairfax, Børge G Nordestgaard, C Moore, Cara L Carty, Carl J Pepine, Chao A Hsiung, Charles Kooperberg, CJ Willer, D Qu, Daniel F Freitag, Daniel J Rader, Daniel R Barnes, Danish Saleheen, Devin Absher, Dewan S Alam, Dirk S Paul, DM Greenawalt, E Grundberg, EE Schadt, Elias L Salfati, Emanuele Di Angelantonio, Eric B Fauman, Eric Boerwinkle, F Innocenti, GA Roth, GR Abecasis, H Kirsten, H Lin, H Schunkert, Heribert Schunkert, HJ Westra, Hugh Watkins, I Holme, I-Te Lee, J Chen, J Dennis, J Erdmann, J Ernst, J Ernst, J Yang, Jeanette Erdmann, Jemma B Wilk, Jerome I Rotter, Joanna M M Howson, John A Spertus, John D Eicher, John Danesh, JR Privratsky, JR Staley, Julie A Johnson, Jyh-Ming J Juang, Kari E North, Katrine L Rasmussen, Kent D Taylor, Kristin Young, LD Ward, Lindsay L Waite, LM Boettger, Lucia A Hindorff, M Arnold, M Narahara, M Uhlen, M Uhlén, Mariaelisa Graff, N Franceschini, Nilesh J Samani, NJ Samani, NL Smith, Nora Franceschini, O Franzén, P Surendran, P Zanoni, Panos Deloukas, Philippe Frossard, Pia R Kamstrup, Praveen Surendran, R Goel, Rajiv Chowdhury, Ren-Hua Chung, Robin Young, Ron Do, S Purcell, Sekar Kathiresan, Stanley L Hazen, Steven Buyske, Sune F Nielsen, T Lappalainen, T Zeller, Themistocles L Assimes, Thomas Quertermous, TL Assimes, TM Teslovich, Tzung-Dau Wang, Ulrike Peters, V Nanda, W Tang, Wayne H H Sheu, Weang-Kee Ho, Wei Zhao, Wei-Yu Lin, Wen-Jane Lee, WJ Astle, X Zhang, X Zhou, Xiuqing Guo, Yi-Jen Hung, Yii-Der Ida Chen, Ying-Hsiang Chen, Z Wang, Å Johansson   +126 more
core   +2 more sources