Results 51 to 60 of about 43,552 (298)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Using Sadrai Model to Interpret the Principle of Equality in Human Rights [PDF]
حکمت صدرایی, 2018 There aretwodiscoursesconcerning human rights: contractual and un-contractual. Equality of law and equality before lawis based onthe equality of the deserving; but, in un-contractual discourse, the equality of the deserving isan objective thing and ...
Abdollah Salavati, Shahnaz Shayanfar
doaj
Perspectives on Federalism, 2017 After a discussion of the impact of the principle of equality, entrenched in the Charters approved in Canada since the 1867 British North American Act, this essay then focuses on the related Supreme Court’s adjudications. A brief analysis of the case-law
Scotti Valentina Rita
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Eşit İşlem İlkesinin Anonim Şirketlerde Pay Sahipleri Dışındaki Kişiler Yönünden Uygulanabilirliği
Sakarya Üniversitesi Hukuk Fakültesi Dergisi/Sakarya Hukuk DergisiSözcük anlamı “kanunlar yönünden insanlar arasında ayrım bulunmaması durumu” olarak tanımlanabilen eşitlik, hem özel hukukta hem kamu hukukunda farklı kapsamlarda yer almaktadır. Türk ticaret hukukunda da yargı kararları ve öğreti tarafından uzun süredir
Habibe Dinç Doğan
doaj +1 more source
RUDN Journal of Law, 2016 The article considers the correlation of general principles of law, the principles of international law and the principles of aw of international organizations.
Aleksandra Andreevna Dorskaya
doaj
The principle of fairness : theory, defence, and application [PDF]
Theories of social justice propose various principles for the just regulation of social institutions and practices. However, why should individuals comply with the rules of just social institutions?
Kim, Dong-il
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source