Results 61 to 70 of about 303,346 (275)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparisons of item difficulty and passing scores by test equating in a basic medical education curriculum [PDF]

Korean Journal of Medical Education, 2019
Purpose Test equating studies in medical education have been conducted only for high-stake exams or to compare two tests given in a single course.
Jung Eun Hwang, Na Jin Kim, Su Young Kim
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Negative Binomial Distribution Efficiency in Finite Mixture of Semi-parametric Generalized Linear Models

پژوهش‌های ریاضی, 2019
Introduction Selection the appropriate statistical model for the response variable is one of the most important problem in the finite mixture of generalized linear models.
Farzad Eskandari
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The role of the RM-ODP computational viewpoint concepts in the MDA approach [PDF]

, 2004
An MDA design approach should be able to accommodate designs at different levels of platform-independence. We have proposed a design approach previously (in [2]), which allows these levels to be identified.
Andrade Almeida, João, Ferreira Pires, L., Ferreira Pires, Luis, van Sinderen, M.J., van Sinderen, Marten J.   +4 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Is pseudo-equivalent groups equating via minimum discriminant information adjustment effective? Evidence from simulation and real data

Frontiers in Education
The traditional way to linking different forms of test typically uses common (or randomly equivalent) examinees or items. When common examinees or items are unavailable due to test properties or administrative restrictions, equating with pseudo ...
Xizhen Fan, Minqiang Zhang, Minqiang Zhang, Minqiang Zhang, Hengli Peng   +4 more
doaj   +1 more source

Matching of analytical and numerical solutions for neutron stars of arbitrary rotation

, 2012
We demonstrate the results of an attempt to match the two-soliton analytical solution with the numerically produced solutions of the Einstein field equations, that describe the spacetime exterior of rotating neutron stars, for arbitrary rotation.
George Pappas, Kluzniak W, Manko V S, Pappas G, Pappas G, Sibgatullin N R, Sibgatullin N R, Sotiriou T P, Stergioulas N, Xanthopoulos B C   +9 more
core   +1 more source