Results 61 to 70 of about 1,494,483 (312)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Title: Misdiagnosis in young females – Autism versus Borderline Personality Disorders

open access: yesEuropean Psychiatry
Introduction The diagnostic overlap between Autism Spectrum Disorder (ASD) and Emotionally Unstable Personality Disorder (EUPD), commonly referred to as Borderline Personality Disorder (BPD), presents a considerable challenge in psychiatric practice ...
H. Sholinghur
doaj   +1 more source

Dynamics of many-body quantum synchronisation

open access: yesNew Journal of Physics, 2018
We analyse the properties of the synchronisation transition in a many-body system consisting of quantum van der Pol oscillators with all-to-all coupling using a self-consistent mean-field method.
C Davis-Tilley, C K Teoh, A D Armour
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Unveiling nontrivial fusion rule of Majorana zero mode using a fermionic mode

open access: yesCommunications Physics
Fusing Majorana zero modes (MZMs) leads to multiple outcomes, a property unique to non-Abelian anyons. The successful demonstration of this nontrivial fusion rule would be a hallmark for the development of topological quantum computation.
Yu Zhang   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight

open access: yesScientific Reports, 2017
Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions.
Angelique Van Ombergen   +11 more
doaj   +1 more source

Essential planetary health workers: Positioning rangers within global policy

open access: yesConservation Letters, 2023
Our planet is facing increasing challenges: climate change, biodiversity loss, pandemics, poverty, and many other problems closely linked to a deteriorating environment.
Sue Stolton   +14 more
doaj   +1 more source

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