Results 71 to 80 of about 1,270,442 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Perspective: Stepping Stones to Unraveling the Pathophysiology of Mal de Debarquement Syndrome with Neuroimaging

Frontiers in Neurology, 2018
Mal de debarquement syndrome (MdDS) is a neurological condition typically characterized by a sensation of motion, which in most cases manifests after disembarking from a vehicle (e.g., boat, plane, and car).
Viviana Mucci, Yoon-Hee Cha, Floris L. Wuyts, Angelique Van Ombergen   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

B-Bridge Regulated Asymmetric Dual-Atomic Catalysts for Synergistically Enhanced Styrene Mineralization and CO2 Reduction

Nano-Micro Letters
Highlights Bifunctional atomic catalyst for dual environmental-energetic applications. Unprecedented catalytic performance: simultaneously 99% flowing-phase styrene degradation and 98% FECO at 1000 mA cm−2.
Xiai Zhang, Zhongshuang Xu, Xinwei Zhang, Jingquan Wang, Dan Liu, Huanran Miao, Tong Wang, Zhimao Yang, Qikui Fan, Chuncai Kong   +9 more
doaj   +1 more source

Magnetic and electronic properties of porphyrin-based molecular nanowires

AIP Advances, 2016
Using spin-polarized density functional theory calculations, we performed theoretical investigations on the electronic and magnetic properties of transition metal embedded porphyrin-based nanowires (TM-PNWs, TM = Cr, Mn, Co, Ni, Cu, and Zn).
Jia-Jia Zheng, Qiao-Zhi Li, Jing-Shuang Dang, Wei-Wei Wang, Xiang Zhao   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Equilibrium: In the balance [PDF]

Nature, 2002
In the social sciences, an equilibrium is a situation that involves several individuals or groups, in which each one's actions turn out to be the best reply to everyone else's.
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Isotherm Adsorbsi Uap Air Komposit Poli(asam laktat) - Grafit

, 2022
<p><strong><span lang="EN-US">ABSTRAK.</span></strong><span lang="EN-US">Poli asam laktat adalah polimer hidrofobik yang termasuk dalam kelas biomaterial yang bersifat biodegradable.
Fadilah Fadilah, Setyawhardani, Dwi Ardiana, Ramadhani, Aida Nur, Fadilah, Fadilah, Aida Nur Ramadhani, Distantina, Sperisa, Fakhruddin, Isa, Dwi Ardiana Setyawhardani, Endang Kwartiningsih, Kaavessina, Mujtahid, Tane, Amaldo Firjarahadi, Isa Fakhruddin, Mujtahid Kaavessina, Amaldo Firjarahadi Tane, Sperisa Distantina, Kwartiningsih, Endang   +15 more
core   +1 more source