Results 71 to 80 of about 4,274,201 (391)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Equilibrium and non-equilibrium fluctuations in a glass-forming liquid
, 2008 Glass-forming liquids display strong fluctuations -- dynamical heterogeneities -- near their glass transition. By numerically simulating a binary Weeks-Chandler-Andersen liquid and varying both temperature and timescale, we investigate the probability ...
Azita Parsaeian +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Preparation of mesoporous activated carbon from novel African walnut shells (AWS) for deltamethrin removal: kinetics and equilibrium studies [PDF]
, 2022 Oluwasuyi Ayobami Oba +1 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Evidence for Biodiversity Conservation in Protected Landscapes
Land, 2016 A growing number of protected areas are defined by the International Union for Conservation of Nature (IUCN) as protected landscapes and seascapes, or category V protected areas, one of six protected area categories based on management approach. Category
Nigel Dudley +4 more
doaj +1 more source
New Journal of Physics, 2023 Coherent quantum transduction between microwave and optical signals is of great importance for long-distance quantum communication. Here we propose a novel scheme for the implementation of nonreciprocal single-photon state conversion between microwave ...
Jikun Xie +5 more
doaj +1 more source
Probing the dynamical state of galaxy clusters
, 2007 We show how hydrostatic equilibrium in galaxy clusters can be quantitatively probed combining X-ray, SZ, and gravitational-lensing data. Our previously published method for recovering three-dimensional cluster gas distributions avoids the assumption of ...
Arnaud +27 more
core +2 more sources
Equilibrium Cycle: A “Dynamic” Equilibrium
In this paper, we introduce a novel equilibrium concept, called the equilibrium cycle, which seeks to capture the outcome of oscillatory game dynamics. Unlike the (pure) Nash equilibrium, which defines a fixed point of mutual best responses, an equilibrium cycle is a set-valued solution concept that can be demonstrated even in games where best ...
Walunj, Tushar Shankar +3 more
openaire +2 more sources
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source