Results 61 to 70 of about 10,252,023 (301)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Market Equilibrium Based on Cloud-edge Collaboration

CSEE Journal of Power and Energy Systems
Market participants can only bid with lagged information disclosure under the existing market mechanism, which can lead to information asymmetry and irrational market behavior, thus influencing market efficiency.
Tong Cheng, Haiwang Zhong, Qing Xia
doaj   +1 more source

Shape control of size-selected naked platinum nanocrystals

Nature Communications, 2021
Tetrahedral nanocrystals are out-of-equilibrium structures whose growth mechanism is a long-standing open problem. Here, the authors show that pure Pt tetrahedral nanocrystals grow in the gas phase and single out the defect-mediated mechanism leading to ...
Yu Xia, Diana Nelli, Riccardo Ferrando, Jun Yuan, Z. Y. Li   +4 more
doaj   +1 more source

Equilibrium mechanisms of receptor clustering

Progress in Biophysics and Molecular Biology, 2009
Receptor clustering is a well-established feature of transmembrane signalling. In some cellular systems, clusters form dynamically in response to activation by an extracellular ligand; in others, extensive 2-dimensional arrays of receptors persist for long periods of time on the cell surface.
Thomas, Duke, Ian, Graham
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale

Nature Methods, 2016
Single-molecule fluorescence microscopy is uniquely suited for detecting transient molecular recognition events, yet achieving the time resolution and statistics needed to realize this potential has proven challenging.
M. Juette, Daniel S. Terry, Michael R. Wasserman, R. Altman, Zhou Zhou, Hong Zhao, S. Blanchard   +6 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dynamic fractional-order ISDR rumor propagation model incorporating refutation mechanism in complex networks

Scientific Reports
Rumor spreading has been posing a significant threat to maintain the normal social order. In this paper, we propose a ISDR rumor propagation model on scale-free networks that considers fractional-order and refutation mechanism.
Weiwei Zhu
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source