Results 61 to 70 of about 1,435,956 (282)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

ON COMPUTATIONAL DIFFERENCES OF CRITICAL POINTS ON EQUILIBRIUM CURVE

International Journal for Computational Civil and Structural Engineering, 2017
In this paper, we discuss the features of investigating the type of the critical point on the equilibrium curve (bifurcation point or limit point). There are new ideas about the completion of the initial equilibrium at the limit point or bifurcation ...
Gaik A. Manuylov, Sergey B. Kosytsyn, Maxim M. Begichev   +2 more
doaj   +1 more source

Partial Information Differential Games for Mean-Field SDEs

, 2016
This paper is concerned with non-zero sum differential games of mean-field stochastic differential equations with partial information and convex control domain.
Xiao, Hua, Zhang, Shuaiqi
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fixed points, intersection theorems, variational inequalities, and equilibrium theorems

International Journal of Mathematics and Mathematical Sciences, 2000
From a fixed point theorem for compact acyclic maps defined on admissible convex sets in the sense of Klee, we first deduce collectively fixed point theorems, intersection theorems for sets with convex sections, and quasi-equilibrium theorems.
Sehie Park
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Study of mathematical models of type 2 diabetes mellitus and its complications

Jurnal Natural
The rapid increase in type 2 diabetes mellitus (DM) cases in Indonesia, driven by hereditary factors and unhealthy lifestyles, poses significant health challenges.
AFIATUN MAGHFIRAH, BASRI A. GANI, MARWAN RAMLI, MUHAMMAD IKHWAN   +3 more
doaj   +1 more source

Stability boundary characterization of nonlinear autonomous dynamical systems in the presence of a type-zero saddle-node equilibrium point

Trends in Computational and Applied Mathematics, 2010
. Under the assumption that all equilibrium points are hyperbolic, the stability boundary of nonlinear autonomous dynamical systems is characterized as the union of the stable manifolds of equilibrium points on the stability boundary.
F.M. Amaral, L. F. C. Alberto, N. G. Bretas   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source