Results 11 to 20 of about 219,775 (187)

Metformin Increases Proliferative Activity and Viability of Multipotent Stromal Stem Cells Isolated from Adipose Tissue Derived from Horses with Equine Metabolic Syndrome [PDF]

Cells, 2019
In this study, we investigated the influence of metformin (MF) on proliferation and viability of adipose-derived stromal cells isolated from horses (EqASCs).
Agnieszka Smieszek, Katarzyna Kornicka, Jolanta Szłapka-Kosarzewska, Peter Androvic, Lukas Valihrach, Lucie Langerova, Eva Rohlova, Mikael Kubista, Krzysztof Marycz   +8 more
doaj   +3 more sources

Associations between endocrine disrupting chemicals and equine metabolic syndrome phenotypes. [PDF]

Chemosphere, 2019
Equine Metabolic Syndrome (EMS) is characterized by abnormalities in insulin regulation, increased adiposity and laminitis, and has several similarities to human metabolic syndrome. A large amount of environmental variability in the EMS phenotype is not explained by commonly measured factors (diet, exercise, and season), suggesting that other ...
Durward-Akhurst SA, Schultz NE, Norton EM, Rendahl AK, Besselink H, Behnisch PA, Brouwer A, Geor RJ, Mickelson JR, McCue ME.   +9 more
europepmc   +5 more sources

Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses [PDF]

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies.
Krzysztof Marycz, Christine Weiss, Agnieszka Śmieszek, Katarzyna Kornicka   +3 more
doaj   +3 more sources

Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome

Frontiers in Microbiomes, 2023
BackgroundThe prevalence of Equine Metabolic Syndrome and insulin dysregulation is increasing in the horse population. Insulin dysregulation is a risk factor for laminitis, which has significant welfare consequences for the horse.
Alexandra von Münchow, Alexandra von Münchow, Sarah Torp Yttergren, Rasmus Riemer Jakobsen, Nanna Luthersson, Axel Kornerup Hansen, Frederikke Lindenberg   +6 more
doaj   +2 more sources

Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses

Marine Drugs, 2017
Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation.
Daria Nawrocka, Katarzyna Kornicka, Agnieszka Śmieszek, Krzysztof Marycz   +3 more
doaj   +2 more sources

Faecal microbiota and serum metabolome association with equine metabolic syndrome in connemara ponies [PDF]

BMC Veterinary Research
Background Faecal microbiome and serum metabolome have been studied in human medicine to provide a better understanding of metabolic derangements including diabetes; however, equivalent studies in equine medicine are limited.
Ahmed Saleh Al-Ansari, Vivienne Duggan, Grace Mulcahy, Xiaofei Yin, Lorraine Brennan, Paul D. Cotter, Shriram H. Patel, Ciara M. O’Donovan, Fiona Crispie, Nicola Walshe   +9 more
doaj   +2 more sources

Use of principle component analysis to quantitatively score the equine metabolic syndrome phenotype in an Arabian horse population. [PDF]

PLoS ONE, 2018
Equine metabolic syndrome (EMS), like human metabolic syndrome, comprises a collection of clinical signs related to obesity, insulin dysregulation and susceptibility to secondary inflammatory disease.
Samantha L Lewis, Heather M Holl, Maureen T Long, Martha F Mallicote, Samantha A Brooks   +4 more
doaj   +2 more sources

Advancing in vitro vascular wall modelling using digital light processing to study hyperglycemia-driven cell changes [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundMetabolic syndrome is a pathological state, frequently associated with type 2 diabetes, which is marked by abdominal obesity, impaired insulin action, hypertension, and vascular wall changes.
Ianina Pokholenko, Ianina Pokholenko, Ianina Pokholenko, Marguerite Meeremans, Marguerite Meeremans, Sandra Van Vlierberghe, Nele Pien, Nele Pien, Catharina De Schauwer   +8 more
doaj   +2 more sources

Occurrence of equine metabolic syndrome, clinical manifestations, and associated risk factors in Nigeria. [PDF]

J Equine Sci, 2023
Insulin dysregulation (ID) is central to the pathophysiology of equine metabolic syndrome (EMS), putting the horse at risk of laminitis. There is a paucity of information on the status of EMS in Nigeria.
Akinniyi OO, Sackey AKB, Ochube GE, Mshelia PW, Musa FA, Elijah MO, Jolayemi KO.   +6 more
europepmc   +2 more sources

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity. [PDF]

Int J Inflam, 2023
Background Hyperactivation of protein tyrosine phosphatase (PTP1B) has been associated with several metabolic malfunctions ranging from insulin resistance, metaflammation, lipotoxicity, and hyperglycaemia.
Bourebaba L, Serwotka-Suszczak A, Bourebaba N, Zyzak M, Marycz K.   +4 more
europepmc   +2 more sources