Results 61 to 70 of about 2,352,578 (343)
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Discrete input equipment design study [PDF]
The study to improve the reliability of the LUT system by discrete input equipment (DIE) is reported. Subjects discussed include: specifications, packaging, aircraft integrated systems, and word formats DIE. It is recommended that maximal use of advanced
core +1 more source
Development of a high stability pointing mechanism for wide application [PDF]
, 1982 A recurrent requirement of spaceborne instruments and communications equipment is that of accurate pointing. This need is recognizable in such diverse applications as Star Sensor trimming, Momentum Wheel gimballing, in-orbit adjustment or alignment of ...
Bentall, R. H., Brunnen, A. J. D.
core +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Apparatus for purging systems handling toxic, corrosive, noxious and other fluids Patent [PDF]
, 1967 Fluid transferring system design for purging toxic, corrosive, or noxious fluids and fumes from materials handling equipment for cleansing and accident ...
Gehring, W. E., Hellmann, R. F.
core +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Design guidelines for remotely maintainable equipment [PDF]
The quantity and complexity of on-orbit assets will increase significantly over the next decade. Maintaining and servicing these costly assets represent a difficult challenge.
Clarke, Margaret M., Manouchehri, Davoud
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Parkes-CDSCC telemetry array: Equipment design [PDF]
A unique combination of Deep Space Network (DSN) and non-DSN facilities in Australia provided enhanced data return from the Voyager spacecraft as it encountered the planet Uranus.
Armstrong, J. W. +3 more
core +1 more source