Results 61 to 70 of about 1,271,490 (330)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Redundant data management system [PDF]
, 1972 Redundant data management system solves problem of operating redundant equipment in real time environment where failures are detected, isolated, and switched in simple manner.
Hall, J. R.
core +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Reliability analysis of wireless communication equipment based on model selection [PDF]
Zhihui kongzhi yu fangzhenThe research of equipment failure distribution is the basis of reliability engineering. In view of the complex structure and failure mechanism of wireless communication equipment, numerous failure distribution types, difficulty in selecting and ...
SUN Jin, HU Jicheng, JIAO Yaqi, WANG Kun
doaj +1 more source
A Data Augmented Bayesian Network for Node Failure Prediction in Optical Networks [PDF]
arXiv, 2021 Failures in optical network backbone can cause significant interruption in internet data traffic. Hence, it is very important to reduce such network outages. Prediction of such failures would be a step forward to avoid such disruption of internet services for users as well as operators.
arxiv
Health and safety in an organisation [PDF]
, 2018 Health and Safety of employees are of utmost importance for the performance of both the employees and the organisation. The main aim of this research project is to study the health and safety issues existing within an organisation.
Sharma, Chirag, Wood, Brent
core
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
High-Strength Bolt Corrosion Fatigue Life Model and Application
The Scientific World Journal, 2014 The corrosion fatigue performance of high-strength bolt was studied. Based on the fracture mechanics theory and the Gerberich-Chen formula, the high-strength bolt corrosion fracture crack model and the fatigue life model were established.
Wang Hui-li, Qin Si-feng
doaj +1 more source
Failure Prediction with Statistical Guarantees for Vision-Based Robot Control [PDF]
arXiv, 2022 We are motivated by the problem of performing failure prediction for safety-critical robotic systems with high-dimensional sensor observations (e.g., vision). Given access to a black-box control policy (e.g., in the form of a neural network) and a dataset of training environments, we present an approach for synthesizing a failure predictor with ...
arxiv
Application of a truncated normal failure distribution in reliability testing [PDF]
, 1968 Statistical truncated normal distribution function is applied as a time-to-failure distribution function in equipment reliability estimations. Age-dependent characteristics of the truncated function provide a basis for formulating a system of high ...
Groves, C., Jr.
core +1 more source