Results 61 to 70 of about 103,330 (308)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Multisensory guided associative learning in healthy humans.
PLoS ONE, 2019 Associative learning is a basic cognitive function by which discrete and often different percepts are linked together. The Rutgers Acquired Equivalence Test investigates a specific kind of associative learning, visually guided equivalence learning.
Gabriella Eördegh +7 more
doaj +1 more source
Indicators of Evidence for Bioequivalence
Entropy, 2016 Some equivalence tests are based on two one-sided tests, where in many applications the test statistics are approximately normal. We define and find evidence for equivalence in Z-tests and then one- and two-sample binomial tests as well as for t-tests ...
Stephan Morgenthaler, Robert Staudte
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Test on equivalence of injections.
, 2013 Test on equivalence of injections.
Balkan Cakir (338563) +4 more
core +1 more source
Understanding Equivalence and Noninferiority Testing [PDF]
Journal of General Internal Medicine, 2010 Increasingly, the goal of many studies is to determine if new therapies have equivalent or noninferior efficacies to the ones currently in use. These studies are called equivalence/noninferiority studies, and the statistical methods for their analysis require only simple modifications to the traditional hypotheses testing framework.
Esteban, Walker, Amy S, Nowacki
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On equivalence and bioequivalence testing.
SORT- Statistics and Operations Research Transactions, 2008 Equivalence testing is the natural approach to many statistical problems. First, its main application, bioequivalence testing, is reviewed. The basic concepts of bioequivalence testing (2×2 crossover designs, TOST, interval inclusion principle, etc.) and its problems (TOST biased character, the carryover problem, etc.) are considered. Next, equivalence
Ocaña Rebull, Jordi +3 more
openaire +5 more sources
Recommendations for applying tests of equivalence [PDF]
Journal of Clinical Psychology, 2003 AbstractResearchers in psychology reliably select traditional null hypothesis significance tests (e.g., Student's t test), regardless of whether the research hypothesis relates to whether the group means are equivalent or whether the group means are different.
Cribbie, Robert +2 more
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source