Results 141 to 150 of about 63,057 (294)
Ecotoxicology and Environmental SafetyDisruption of estrogen receptor alpha (ERα) by endocrine-active pesticides may contribute to lipid metabolic dysregulation. We aimed to clarify the docking dynamics of methiocarb with ERα and evaluate its potential to induce lipid accumulation through ...
Da-Hyun Jeong +4 more
doaj +1 more source
Molecular Systems Biology, 2011 Despite the role of the estrogen receptor α (ERα) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERα into ERα‐negative cells paradoxically has been growth inhibition.
Say Li Kong +4 more
doaj +1 more source
Expression of ERα, GPR30 and pFAK (at Y397) in human endometrial cancers with low ERα.
, 2013 (A) In clinical samples of human endometrial cancers with low expression of ERα (histoscore = 10), relatively high expression of GPR30 (histoscore = 270) and pFAK (histoscore = 225) were observed (40× magnification of the object lens).
Chiao-Yun Lin (383113) +8 more
core +1 more source
FastNano Liquid: An Automated Platform for Small‐Angle X‐ray Scattering‐Based Materials Discovery
Advanced Engineering Materials, EarlyView.We present FastNano Liquid, an automated small‐ and wide‐angle X‐ray scattering platform for the combined synthesis and characterization of (nano)materials. The platform is coupled to varied reactor workflows for both in situ studies of reaction kinetics and ex situ screening of synthesis conditions to support machine learning‐guided exploration ...
Pierre‐Baptiste Flandrin +16 more
wiley +1 more source
Cancer Research, 2016 Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer. Recent epidemiologic and clinical studies of endometrial cancer have also revealed a role for insulin resistance, clinically ...
C. Ning +12 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone +11 more
wiley +1 more source
Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer
Oncogene, 2016 Estrogen receptor α (ERα) is a master driver of a vast majority of breast cancers. Breast cancer cells often develop resistance to endocrine therapy via restoration of the ERα activity through survival pathways.
Lihou Yu +8 more
semanticscholar +1 more source
ERα localization in the tissues of HPO axis.
, 2014 (A) Histological sections of ERαf/f (a) and ERαd/d (b) hypothalami, ERαf/f (c) and ERαd/d (d) pituitaries, ERαf/f ovary (e, g) and ERαd/d ovarian tumor (f, h) from adult mice at 6 months of age stained with anti-ERα.
Indrani C. Bagchi (181462) +5 more
core +1 more source
Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions
Advanced Functional Materials, EarlyView.This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian +7 more
wiley +1 more source
JMJD6 specifically interacts with the methylated form of ERα.
, 2014 (A) In vitro synthesized and radiolabelled ERα protein was incubated with GST-JMJD6 and binding was analysed by autoradiography. Luciferase was used as a negative control. The lower panel shows the corresponding coomassie staining. (B) MCF-7 were treated
Muriel Le Romancer (518954) +4 more
core +1 more source