Results 121 to 130 of about 63,057 (294)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang +7 more
wiley +1 more source
Hormones & cancer, 2017 Estrogen receptor α (ERα) is a crucial transcriptional regulator in breast cancer, but estrogens mediate their effects through two estrogen receptors, ERα and ERβ, subtypes that have contrasting regulatory actions on gene expression and the survival and ...
Wenwen Lu, B. Katzenellenbogen
semanticscholar +1 more source
ERα expression in PERαKO−/− hypothalamus.
, 2014 Pdx1-Cre/Lacz mouse and immunofluorescence in frontal brain sections from PERαKO−/− mice. Pdx-1 expression (red) marked by beta galactosidase (β-gal) and ERα (green) show PDX-1 and ERα co-expression in the ventromedial hypothalamus (VMH), the preoptic ...
Martin G. Myers Jr (519246) +10 more
core +1 more source
OncoTarget, 2016 Breast cancer is a common malignancy in women. Acquisition of drug resistance is one of the main obstacles encountered in breast cancer therapy. Long non-coding RNA (lncRNA) has been demonstrated to play vital roles in both development and tumorigenesis.
X. Si +13 more
semanticscholar +1 more source
Estrogen signals to moesin via ERα.
, 2013 T47-D (A and D) , MCF-7 (B and E) or MDA-MB-468 (C) cells were treated for 15 minutes with either E2 (10 nM), the preferential ERα agonist PPT (10 nM) or the preferential ERβ agonist, DPN (10 nM), in the presence or absence of the ER antagonist, ICI 182 ...
Xiao-Dong Fu (47457) +10 more
core +1 more source
microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan +4 more
wiley +1 more source
Role of Brf1 interaction with ERα, and significance of its overexpression, in human breast cancer
Molecular Oncology, 2017 TFIIB‐related factor 1 (Brf1) modulates the transcription of RNA Pol III genes (polymerase‐dependent genes). Upregulation of Pol III genes enhances tRNA and 5S RNA production and increases the translational capacity of cells to promote cell ...
Z. Fang +9 more
semanticscholar +1 more source
Distances between BPA and ERα.
, 2013 Distances between BPA and ERα.
Charlie Chandsawangbhuwana (31494) +1 more
core +1 more source
From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Arthritis Care &Research, EarlyView.Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source
Türk Biyokimya DergisiHuman estrogen receptor alpha (ERα) is considered an important target, especially in the treatment of breast cancer, as it has a vital role in cancer development. ERα-targeted therapies generally target the ligand binding domain (LBD) of ERα.
Şentürk Hilal +9 more
doaj +1 more source