Results 101 to 110 of about 43,370 (253)

ERα-positive human breast cancer cells are more sensitive to TSC than ERα-negative breast cancer cells.

, 2014
Two immortalized mammary epithelial cell lines (MCF10A and 184B5), two ERα-positive breast cancer cell lines (MCF7 and T47D), and two ERα-negative breast cancer cell lines (SW527 and HCC1937) were treated with different concentrations of TSC (0.125, 0.25,
Shuang Wang (46453), Ceshi Chen (605884), Chengzhi Du (559587), Jian Dong (356555), Jingkun Wang (610768), Zhen Li (49109), Zhongmei Zhou (605881)   +6 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

ERα-36 regulates progesterone receptor activity in breast cancer

, 2020
: Background: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer (BC).
Poulard, Coralie, Omarjee, Soleilmane, Kassem, Loay, Konan, Henri-Philippe, Rezza, Amélie, Surmieliova-Garnès, Ausra, Le Romancer, Muriel, Jacquemetton, Julien, Cascales, Elodie, Treilleux, Isabelle, Trédan, Olivier   +10 more
core   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

ERα localization in the tissues of HPO axis.

, 2014
(A) Histological sections of ERαf/f (a) and ERαd/d (b) hypothalami, ERαf/f (c) and ERαd/d (d) pituitaries, ERαf/f ovary (e, g) and ERαd/d ovarian tumor (f, h) from adult mice at 6 months of age stained with anti-ERα.
Indrani C. Bagchi (181462), Mary J. Laws (531779), Athilakshmi Kannan (483347), Wanda M. Haschek (531781), Sandeep Pawar (531780), Milan K. Bagchi (181461)   +5 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Integrative in silico and in vitro approach for clarifying mode of action to activate estrogen receptor alpha and lipid accumulation by methiocarb

Ecotoxicology and Environmental Safety
Disruption of estrogen receptor alpha (ERα) by endocrine-active pesticides may contribute to lipid metabolic dysregulation. We aimed to clarify the docking dynamics of methiocarb with ERα and evaluate its potential to induce lipid accumulation through ...
Da-Hyun Jeong, Rajesh Kumar Pathak, Eunhee Lee, Jun-Mo Kim, Hee-Seok Lee   +4 more
doaj   +1 more source

Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand‐inducible growth state

Molecular Systems Biology, 2011
Despite the role of the estrogen receptor α (ERα) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERα into ERα‐negative cells paradoxically has been growth inhibition.
Say Li Kong, Guoliang Li, Siang Lin Loh, Wing‐Kin Sung, Edison T Liu   +4 more
doaj   +1 more source

A modulator based regulatory network for ERα signaling pathway

, 2012
Background: Estrogens control multiple functions of hormone-responsive breast cancer cells. They regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of gene ...
Guanglong Jiang, Nephew, Kenneth P., Huang, Tim H. M., Jiang, Guanglong, Lang Li, Liu, Yunlong, Kenneth P Nephew, Zheng, Pengyue, Pengyue Zheng, Yunlong Liu, Heng-Yi Wu, Wu, Heng-Yi, Li, Lang, Tim HM Huang   +13 more
core   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source