Results 81 to 90 of about 43,370 (253)

Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1–NDRG1 deregulation

Molecular Oncology
Breast cancer (BCa) is a highly heterogeneous disease, with hormone receptor status being a key factor in patient prognostication and treatment decision‐making.
Isabel Mayayo‐Peralta, Donna O. Debets, Stefan Prekovic, Karianne Schuurman, Suzanne Beerthuijzen, Mathilde Almekinders, Joyce Sanders, Cathy B. Moelans, Sandra Saleiro, Jelle Wesseling, Paul J. vanDiest, Rui Henrique, Carmen Jerónimo, Maarten Altelaar, Wilbert Zwart   +14 more
doaj   +1 more source

Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression

, 2017
Unlike breast cancer that is positive for estrogen receptor-α (ERα), there are no targeted therapies for triple-negative breast cancer (TNBC). ERα is silenced in TNBC through epigenetic changes including DNA methylation and histone acetylation. Restoring
Brian Fleischer, Margarite Matossian, David Hangauer, Yifang Zhang, Yuanjun Gao, Van Hoang, Brian G. Rowan, Matthew E. Burow, Bridgette M. Collins-Burow, Muralidharan Anbalagan, Mei Sheng, Hope E. Burks   +11 more
core   +1 more source

Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα

Scientific Reports, 2019
Cadmium is an environmental contaminant that can activate estrogen receptor alpha (ERα) and contribute to the development and progression of breast cancer. Our lab previously demonstrated that chronic cadmium exposure alters the expression of several ERα-
Mathew Bloomfield, Maggie C. Louie
doaj   +1 more source

Binding specificities of estrogen receptor with perfluorinated compounds: A cross species comparison

Environment International, 2020
Background: Perfluorinated compounds (PFCs) were reported to result in the endocrine disruption by activating the estrogen receptor (ER) and inducing ER-mediated transcriptions.
Zhiqiang Qiu, Kaili Qu, Feng Luan, Yaquan Liu, Yu Zhu, Yongna Yuan, Hongyu Li, Haixia Zhang, Ying Hai, Chunyan Zhao   +9 more
doaj   +1 more source

A Regulatory “miRcircuitry” Involving miR221&222 and ERα Determines ERα Status of Breast Cancer Cells

, 2009
Estrogen Receptor α (ERα) is the most important diagnostic and prognostic factor in breast cancer. Several lines of evidence have suggested that ERα-negative breast tumors, highly aggressive and non-responsive to hormonal therapy, arise from ERα ...
Di Leva, Gianpiero
core  

ERα expression in PERαKO^−/− hypothalamus.

, 2014
Pdx1-Cre/Lacz mouse and immunofluorescence in frontal brain sections from PERαKO−/− mice. Pdx-1 expression (red) marked by beta galactosidase (β-gal) and ERα (green) show PDX-1 and ERα co-expression in the ventromedial hypothalamus (VMH), the preoptic ...
Martin G. Myers Jr (519246), Gamze Kilic (519242), Jean-Christophe Jonas (129671), Franck Mauvais-Jarvis (275208), Bader Zarrouki (519244), Laura C. Alonso (425745), Rohit N. Kulkarni (256833), Chong Wee Liew (118043), Vincent Poitout (167976), Ana I. Alvarez-Mercado (519243), Darren Opland (519245)   +10 more
core   +1 more source

TNFα Enhances Tamoxifen Sensitivity through Dissociation of ERα-p53-NCOR1 Complexes in ERα-Positive Breast Cancer

, 2021
Tamoxifen is widely used as a medication for estrogen receptor α (ERα)-positive breast cancer, despite the ~50% incidence of tamoxifen resistance. To overcome such resistance, combining tamoxifen with other agents is considered an effective approach ...
Sungmin Kwak, Ji-Hoon Jeong, Ji-Hye Song, Seung-Ho Park, Gi-Jun Sung, Hyo-Kyoung Choi, Jin-Taek Hwang, Min-Jeong Kong, Hyunhee Kim, Jangho Lee, Kyung-Chul Choi   +10 more
core   +1 more source

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells

Journal of Pharmacological Sciences, 2015
The estrogen receptor alpha (ERα) has been proven to be one of the most important therapeutic targets in breast cancer over the last 30 years. Previous studies pointed out that a natural flavonoid, silibinin, induced apoptosis in human breast cancer MCF ...
Nan Zheng, Ping Zhang, Huai Huang, Weiwei Liu, Toshihiko Hayashi, Linghe Zang, Ye Zhang, Lu Liu, Mingyu Xia, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima   +11 more
doaj   +1 more source

Trajectories of Physical Function in Canadian Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, for the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry Investigators, David A. Cabral, Gaëlle Chédeville, Ciarán M. Duffy, Kerstin Gerhold, Jaime Guzman, Linda Hiraki, Adam M. Huber, Heinrike Schmeling, Natalie J. Shiff, Lori B. Tucker, Julie Barsalou, Daniah Basodan, Michelle Batthish, Roberta A. Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns, David A. Cabral, Sarah Campillo, Tania Cellucci, Mercedes Chan, Gaëlle Chédeville, Amieleena Chhabra, Julie Couture, Paul Dancey, Jean‐Jacques De Bruycker, Erkan Demirkaya, Muhammed Dhalla, Ciarán M. Duffy, Talal El Tal, Tommy Gerschman, Jaime Guzman, Liane Heale, Julie Herrington, Kristin M. Houghton, Adan M. Huber, Andrea Human, Nicole Johnson, Roman Jurencak, Bianca Lang, Claire LeBlanc, Lillian Lim, Lily S. H. Lim, Nadia Luca, Jeanine McColl, Tara McGrath, Tamara McMillan, Megan McPherson, Paivi Miettunen, Kimberly Morishita, Honyan Ng, Jonathan Park, Jean‐Philippe Proulx‐Gauthier, Johannes Roth, Evelyn Rozenblyum, Dax G. Rumsey, Heinrike Schmeling, Rosie Scuccimarri, Gordon Soon, Rebeka Stevenson, Elizabeth Stringer, Herman Tam, Lori B. Tucker, Marinka Twilt, Ruud H. J. Verstegen, Karen Watanabe Duffy   +81 more
wiley   +1 more source