Results 1 to 10 of about 17,657 (203)

OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist [PDF]

Scientific Reports
Estrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young, Timothy H. Helms, Samuel K. Kulp, Adeoluwa A. Adeluola, Hanna S. Radomska, Tyler A. Wilson, Reena Shakya, Alyssa Kabat, Gillian Mulcahy, Abigail K. Mayo, Raphael A. Malbrue, William C. Kisseberth, Chad E. Bennett, Christopher C. Coss   +13 more
doaj   +2 more sources

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2020
Background Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells.
Jin Hwan Lee, Han Kyeom Kim, Bong Kyung Shin   +2 more
doaj   +1 more source

Divergent features of ERβ isoforms in triple negative breast cancer: progress and implications for further research

Frontiers in Cell and Developmental Biology, 2023
Estrogen receptor β (ERβ) was discovered more than 20 years ago. However, the extent and role of ERβ expression in breast cancer remain controversial, especially in the context of triple-negative breast cancer (TNBC). ERβ exists as multiple isoforms, and
Shunchao Yan, Jinpeng Wang, Hong Chen, Duo Zhang, Murshid Imam   +4 more
doaj   +1 more source

Effectiveness of Extract Supplements (Apium graveolens L.) to Estrogen Receptors Expression and Oocyte Diameter at Nucleolar Chromatin and Perinucleolar Stages in Female of Nile tilapia (Oreochromis niloticus L.)

Journal of Experimental Life Science, 2023
The study of the use of celery (Apium graveolens L.) in the health sector has been widely discussed. The analysis of the use of celery in the process of oocyte development still needs to be addressed.
Novy Kurnia Rikardo, Agung Pramana Warih Marhendra, Nia Kurniawan, Wibi Riawan, Sri Rahayu   +4 more
doaj   +1 more source

Neuroanatomical association of hypothalamic HSD2-containing neurons with ERα, catecholamines, or oxytocin: implications for feeding? [PDF]

Frontiers in Systems Neuroscience, 2015
This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the α subtype of estrogen receptor (ERα), catecholamines, and/or oxytocin (OT).
Askew, Maegan L., Muckelrath, Halie D., Johnston, Jonathon R., Curtis, Kathleen S.   +3 more
openaire   +3 more sources

Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch

Journal for ImmunoTherapy of Cancer, 2021
BackgroundThe non-overlapping functions of the two estrogen receptor subtypes, ERα (Estrogen Receptor α)and ERβ (Estrogen Receptor β), in tumor cells have been studied extensively.
Jing Yang, Rong Li, Bin Yuan, Curtis A Clark, Bogang Wu, Justin M Drerup, Tianbao Li, Victor X Jin, Yanfen Hu, Tyler J Curiel   +9 more
doaj   +1 more source

The effect of purple sweet potato (Ipomea batatas L) ethanol extract on Estrogen Receptor Alpha (ERα) and SOD mRNA expression in the menopause-liver animal model

Bali Medical Journal, 2020
Background: Aging and estrogen deficiency in menopause women increase susceptibility to liver diseases. In postmenopausal women, the change of ERα expressions and oxidative stress is related to liver diseases' pathogenesis. Phytoestrogens have been shown to protect and repair the liver organ due to estrogen deficiency.
I Wayan Sugiritama, Ida Ayu Ika Wahyuniari, I Gusti Ayu Dewi Ratnayanti, Ni Made Linawati, I Gusti Nyoman Sri Wiryawan, Ni Luh Gede Yoni Komalasari, I Gusti Kamasan Nyoman Arijana   +6 more
openaire   +1 more source

ERβ Isoforms Have Differential Clinical Significance in Breast Cancer Subtypes and Subgroups

Current Issues in Molecular Biology, 2022
ERβ, an ER subtype first identified in 1996, is highly expressed in different types of BCa including ERα-negative BCa and TNBC. Many studies on ERβ expression investigated mostly on ERβ1 protein expression in ERα-positive and ERα-negative BCa combined ...
Young Choi, Hadong Kim, Simcha Pollack
doaj   +1 more source

Mapping ERβ genomic binding sites reveals unique genomic features and identifies EBF1 as an ERβ interactor. [PDF]

PLoS ONE, 2013
Considerable effort by numerous laboratories has resulted in an improved understanding of estrogen and SERM action mediated by the two estrogen receptors, ERα and ERβ. However, many of the targets for ERβ in cell physiology remain elusive.
Thien P Le, Miao Sun, Xin Luo, W Lee Kraus, Geoffrey L Greene   +4 more
doaj   +1 more source