Results 1 to 10 of about 306,344 (322)

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer [PDF]

Frontiers in Oncology, 2022
BackgroundAmong women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all breast cancer subtypes.
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Mahmoud Kassem, Tyler A. Wilson, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Christopher C. Coss, Christopher C. Coss, Chad E. Bennett, Chad E. Bennett, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Daniel G. Stover, Daniel G. Stover, Mathew A. Cherian, Mathew A. Cherian   +27 more
doaj   +2 more sources

Potent estrogen receptor β agonists with inhibitory activity in vitro, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells [PDF]

Frontiers in Oncology
ObjectiveSeventy percent of newly diagnosed breast cancers are estrogen receptor-α positive and HER2/neu negative. First-line treatments incorporate endocrine therapy and cyclin-dependent kinase 4/6 inhibitors.
Lynn M. Marcho, Christopher C. Coss, Christopher C. Coss, Menglin Xu, Jharna Datta, Jasmine M. Manouchehri, Mathew A. Cherian   +6 more
doaj   +2 more sources

Expression of estrogen receptors alpha (ERs α) and folliculogenesis profile in ovary of the rats ovarian hypofunction model [PDF]

Jurnal Ilmu-Ilmu Peternakan, 2021
Ovarian hypofunction is one of the reproductive disorders that occur due to a decrease in ovarian function that causes animals to not experience heat. The purpose of this study was to determine the effect of GnRH antagonist hormone interventions on ovarian hypofunction model rats by looking at the expression of alpha ERs (ERs α) and the profile of ...
Aulia Firmawati, Mitra Artha Kurnia Hutabarat, Herlina Pratiwi, Alibiruni Haryo   +3 more
openaire   +2 more sources

Screening and characterization estrogen receptor ligands from Arnebia euchroma (Royle) Johnst. via affinity ultrafiltration LC-MS and molecular docking

Frontiers in Plant Science, 2022
Arnebiae Radix (dried root of Arnebia euchroma (Royle) Johnst.) is a traditional Chinese medicine (TCM) used to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammations.
Lian Zhu, Lian Zhu, Sheng-jun Ma, Ming-juan Liu, Kai-lin Li, Shuai E, Zi-ming Wang, Sha-ni Li, Sheng-lan Zhang, Wei Cai   +9 more
doaj   +1 more source

SARS-Cov2 S Protein Features Potential Estrogen Binding Site

Food Technology and Biotechnology, 2021
Research background. During the current SARS-CoV2 pandemic, as well as earlier SARS and MERS epidemics, it has been observed that COVID19-positive women on average tend to have milder symptoms and lower fatality rates than men.
Ante Tomasović, Damir Stanzer, Ivan Krešimir Svetec, Marina Svetec Miklenić   +3 more
doaj   +1 more source

Estrogen Biosynthesis and Signal Transduction in Ovarian Disease

Frontiers in Endocrinology, 2022
Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled estrogen receptor (GPER) mRNA could be detected in ovary, suggesting that they play an ...
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng   +5 more
doaj   +1 more source

The Effect of Sambiloto Extract on the Expression of β Estrogen Receptors in Ovaries and Lust Cycle in Mice Model PCOS - Insulin Resistance [PDF]

Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery), 2021
Infertility was a serious problem in the reproductive period, one of the caused of infertility were common in women of childbearing age group is Polycystic Ovary Syndrome (PCOS).Sambiloto (Andrographis paniculata Nees), had been already known contain flavonoid and lactones.
openaire   +1 more source

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors [PDF]

Frontiers in Neuroscience, 2015
Zebrafish is increasingly used as an animal model to study the effects of environmental nuclear receptors (NRs) ligands. As most of these compounds have only been tested on human NRs, it is necessary to measure their effects on zebrafish NRs. Estrogen receptors (ER) α and β and peroxysome proliferator activated receptor (PPAR) γ are main targets of ...
Grimaldi, Marina, Boulahtouf, Abdelhay, Delfosse, Vanessa, Thouennon, Erwan, Bourguet, William, Balaguer, Patrick   +5 more
openaire   +4 more sources

Urethral dysfunction in female mice with estrogen receptor β deficiency. [PDF]

PLoS ONE, 2014
Estrogen has various regulatory functions in the growth, development, and differentiation of the female urogenital system. This study investigated the roles of ERβ in stress urinary incontinence (SUI).
Yung-Hsiang Chen, Chao-Jung Chen, Shuyuan Yeh, Yu-Ning Lin, Yang-Chang Wu, Wen-Tsong Hsieh, Bor-Tsang Wu, Wen-Lung Ma, Wen-Chi Chen, Chawnshang Chang, Huey-Yi Chen   +10 more
doaj   +1 more source

Estrogen Receptor Function: Impact on the Human Endometrium

Frontiers in Endocrinology, 2022
The physiological role of estrogen in the female endometrium is well established. On the basis of responses to steroid hormones (progesterone, androgen, and estrogen), the endometrium is considered to have proliferative and secretory phases. Estrogen can
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng   +5 more
doaj   +1 more source