Results 21 to 30 of about 106,810 (131)
Breast Cancer: Basic and Clinical Research, 2021 Two estrogen receptor isoforms (ERα and ERβ) have been characterized with variable and sometimes contrasting responses to estrogens, partially explained by different receptor signaling pathways in estrogen-sensitive tissues.
Manar G Shalabi +4 more
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Neural Regeneration Research, 2021 Postmenopausal women with Alzheimer’s disease (AD) exhibit dramatically reduced sensitivity to estrogen replacement therapy, which is though to be related to an estrogen receptor (ER)α/ERβ ratio imbalance arising from a significantly decreased level of ...
Yan-Zhen Li +5 more
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Membrane estrogen signaling in female reproduction and motivation
Frontiers in Endocrinology, 2022 Estrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding.
Caroline S. Johnson +2 more
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Journal of Bone Oncology, 2017 This study aimed to investigate the effects of Estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms involved in this process. Osteosarcoma U2-OS cells consisted four groups, and treated by E2, E2 + LY294002 (ERβ agonists), E2 + ERβ siRNA, E2 + ERβ siRNA + LY294002, respectively.
Minfei Yang +4 more
openaire +3 more sources
Estrogen inhibits renal cell carcinoma cell progression through estrogen receptor-β activation. [PDF]
PLoS ONE, 2013 Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts for approximately 3% of adult malignancies. The RCC incidence rate increases annually and is twofold higher in males than in females.
Cheng-Ping Yu +8 more
doaj +1 more source
Modulation of Nrf2 by Activation of Estrogen Receptor β as a Therapeutic Strategy to Prevent Cancer Development and Overcome Inflammation-Related Drug Resistance in Breast Cancer [PDF]
Pharmaceutical Sciences, 2023 Despite the tremendous progress in breast cancer diagnosis and treatment, the mortality rate is expected to increase due to the emergence of drug resistance. Pro-inflammatory markers are thought to contribute to drug resistance by activation of its naive
Emdormi Rymbai +4 more
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Oxytocin and Estrogen Receptor β in the Brain: An Overview
Frontiers in Endocrinology, 2015 Oxytocin is a neuropeptide synthesized primarily by neurons of the paraventricular and supraoptic nuclei of the hypothalamus. These neurons have axons that project into the posterior pituitary and release oxytocin into the bloodstream to promote labor ...
Alexandra eAcevedo-Rodriguez +2 more
doaj +1 more source
, 2015 Additional file 1. Table S1: Known Hh-signaling pathway target genes. Table S2: Result of all pairwise comparisons of differentially expressed genes. Table S3: Hh-signaling differentially responsive genes.
Lu, Yuan +3 more
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Journal of Lipid Research, 2016 Elevated plasma TGs increase risk of cardiovascular disease in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood.
Brian T. Palmisano +4 more
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, 2015 Additional file 2. Figure S1: Genes regulated by either Esrrb or Hh-signaling pathway. Figure S2: Decision tree model of gene sorting. Figure S3: Hh-responsive transcription-related genes. Figure S4: Correlation of qPCR and RNA-seq of top 15 Hh differentially responsive genes. Figure S5: Esrrb-dependent Hh-responsive genes.
Lu, Yuan +3 more
openaire +1 more source