Results 31 to 40 of about 306,344 (322)
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
Asian Pacific Journal of Reproduction, 2015 Objective: To investigate the effect of genistein on proinflammatory cytokines, NF-κ B activation, and estrogen receptor-β expression in a mice model of endometriosis.
Sutrisno Sutrisno +6 more
doaj +1 more source
Neural Regeneration Research, 2021 Postmenopausal women with Alzheimer’s disease (AD) exhibit dramatically reduced sensitivity to estrogen replacement therapy, which is though to be related to an estrogen receptor (ER)α/ERβ ratio imbalance arising from a significantly decreased level of ...
Yan-Zhen Li +5 more
doaj +1 more source
Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]
, 1989 Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla +36 more
core +1 more source
Breast Cancer: Basic and Clinical Research, 2021 Two estrogen receptor isoforms (ERα and ERβ) have been characterized with variable and sometimes contrasting responses to estrogens, partially explained by different receptor signaling pathways in estrogen-sensitive tissues.
Manar G Shalabi +4 more
doaj +1 more source
Modulation of Nrf2 by Activation of Estrogen Receptor β as a Therapeutic Strategy to Prevent Cancer Development and Overcome Inflammation-Related Drug Resistance in Breast Cancer [PDF]
Pharmaceutical Sciences, 2023 Despite the tremendous progress in breast cancer diagnosis and treatment, the mortality rate is expected to increase due to the emergence of drug resistance. Pro-inflammatory markers are thought to contribute to drug resistance by activation of its naive
Emdormi Rymbai +4 more
doaj +1 more source
Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor [PDF]
, 2016 To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular ...
Frizziero, Luisa +7 more
core +1 more source
Membrane estrogen signaling in female reproduction and motivation
Frontiers in Endocrinology, 2022 Estrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding.
Caroline S. Johnson +2 more
doaj +1 more source
Estrogen inhibits renal cell carcinoma cell progression through estrogen receptor-β activation. [PDF]
PLoS ONE, 2013 Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts for approximately 3% of adult malignancies. The RCC incidence rate increases annually and is twofold higher in males than in females.
Cheng-Ping Yu +8 more
doaj +1 more source
Journal of Bone Oncology, 2017 This study aimed to investigate the effects of Estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms involved in this process. Osteosarcoma U2-OS cells consisted four groups, and treated by E2, E2 + LY294002 (ERβ agonists), E2 + ERβ siRNA, E2 + ERβ siRNA + LY294002, respectively.
Minfei Yang +4 more
openaire +3 more sources