Results 31 to 40 of about 2,198,676 (277)

Nk3R blockade has sex-divergent effects on memory in mice

Biology of Sex Differences, 2022
Highlights Nk3R antagonism reduces recognition memory consolidation in male mice and increases it in proestrus females. Androgen receptor expression is higher in the CA1 compared to DG, CA3, and the mPFC. Estrogen repcetor α expression is higher in males
Antonio Florido, Estefanía Moreno, Enric I. Canela, Raül Andero   +3 more
doaj   +1 more source

Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors [PDF]

Frontiers in Neuroscience, 2014
Estrogen action through estrogen receptor α (ERα) is involved in the control of sexual and social behaviors in adult mammals. Alteration of ERα gene activity mediated by epigenetic mechanisms, such as histone modifications and DNA methylation, in particular brain areas appears to be crucial for determining the extents of these behaviors between the ...
openaire   +3 more sources

Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]

, 2010
In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo, Elling, Dirk, Heinemann, Volker   +2 more
core   +1 more source

Effect of genistein on proinflammatory cytokines and estrogen receptor–β in mice model of endometriosis

Asian Pacific Journal of Reproduction, 2015
Objective: To investigate the effect of genistein on proinflammatory cytokines, NF-κ B activation, and estrogen receptor-β expression in a mice model of endometriosis.
Sutrisno Sutrisno, RR Catur Leny Wulandari, Dwi Wahyu Wulan Sulistyowati, Ratna Feti Wulandari, Endang Sri Wahyuni, Yuyun Yueniwati, Sanarto Santoso   +6 more
doaj   +1 more source

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Neural Regeneration Research, 2021
Postmenopausal women with Alzheimer’s disease (AD) exhibit dramatically reduced sensitivity to estrogen replacement therapy, which is though to be related to an estrogen receptor (ER)α/ERβ ratio imbalance arising from a significantly decreased level of ...
Yan-Zhen Li, Yuan-Jie Liu, Wei Zhang, Shi-Fang Luo, Xin Zhou, Gui-Qiong He   +5 more
doaj   +1 more source

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
core   +1 more source

The Prognostic Value of Estrogen Receptor β Isoform With Correlation of Estrogen Receptor α Among Sudanese Breast Cancer Patients

Breast Cancer: Basic and Clinical Research, 2021
Two estrogen receptor isoforms (ERα and ERβ) have been characterized with variable and sometimes contrasting responses to estrogens, partially explained by different receptor signaling pathways in estrogen-sensitive tissues.
Manar G Shalabi, Anass M Abbas, Jeremy Mills, Mohamed A Kheirelseid, Abozer Y Elderdery   +4 more
doaj   +1 more source

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]

, 2011
The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Vincken, J.P., Bovee, T.F.H., Luijendijk, T.J.C., Verbruggen, M.A., The, S.A.M., Mol, L.A.M., Simons, R., Gruppen, H.   +7 more
core   +1 more source

Membrane estrogen signaling in female reproduction and motivation

Frontiers in Endocrinology, 2022
Estrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding.
Caroline S. Johnson, Paul E Micevych, Paul G. Mermelstein   +2 more
doaj   +1 more source

MOESM1 of Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β

, 2015
Additional file 1. Table S1: Known Hh-signaling pathway target genes. Table S2: Result of all pairwise comparisons of differentially expressed genes. Table S3: Hh-signaling differentially responsive genes.
Lu, Yuan, Li, Jilong, Cheng, Jianlin, Lubahn, Dennis   +3 more
openaire   +1 more source