Results 11 to 20 of about 22,519 (238)

Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1

BMC Biology, 2023
Background Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.
Madeleine Birgersson, Rajitha Indukuri, Linnéa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer, Cecilia Williams   +7 more
doaj   +2 more sources

The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading [PDF]

Genome Biology, 2017
Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing ...
Roberta Tarallo, Giorgio Giurato, Giuseppina Bruno, Maria Ravo, Francesca Rizzo, Annamaria Salvati, Luca Ricciardi, Giovanna Marchese, Angela Cordella, Teresa Rocco, Valerio Gigantino, Biancamaria Pierri, Giovanni Cimmino, Luciano Milanesi, Concetta Ambrosino, Tuula A. Nyman, Giovanni Nassa, Alessandro Weisz   +17 more
doaj   +4 more sources

OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist

Scientific Reports
Estrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young, Timothy H. Helms, Samuel K. Kulp, Adeoluwa A. Adeluola, Hanna S. Radomska, Tyler A. Wilson, Reena Shakya, Alyssa Kabat, Gillian Mulcahy, Abigail K. Mayo, Raphael A. Malbrue, William C. Kisseberth, Chad E. Bennett, Christopher C. Coss   +13 more
doaj   +2 more sources

Targeting newly identified ERβ/TGF‐β1/SMAD3 signals with the FDA‐approved anti‐estrogen Faslodex or an ERβ selective antagonist in renal cell carcinoma

Molecular Oncology, 2018
Renal cell carcinoma (RCC) has the third highest mortality rate among urological tumors, and 20–30% of RCC patients present with metastatic RCC at the time of diagnosis.
Wenbin Song, Dalin He, Yule Chen, Chiuan‐Ren Yeh, Iawen Hsu, Qingbo Huang, Xu Zhang, Luke Sien‐Shih Chang, Li Zuo, Jiasheng Chen, Karen M. Doersch, Chawnshang Chang, Lei Li, Shuyuan Yeh   +13 more
doaj   +2 more sources

A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals [PDF]

Heliyon
In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER ...
Derek A. Abbott, Maureen G. Mancini, Michael J. Bolt, Adam T. Szafran, Kaley A. Neugebauer, Fabio Stossi, Daniel A. Gorelick, Michael A. Mancini   +7 more
doaj   +2 more sources

ERβ and Inflammation

, 2022
Estrogen, through the regulation of cytokine production, can act both as pro-inflammatory and anti-inflammatory signals dependent on the tissue context. In breast cancer cells, ERα is known to modulate inflammatory signaling through interaction with NFκB.
Hases, L, Archer, A,, Williams, C,, Williams, Cecilia,, Archer, Amena,, Hases, Linnea,   +5 more
core   +1 more source

Gene expression of estrogen receptor during different stages of pregnancy in rats model [PDF]

Iraqi Journal of Veterinary Sciences
One essential organ that steroid hormones target is the uterus and ovaries. Many receptors mediate the effects of these hormones such as estrogen receptors ER.
Enas O. Al-Babily, Barra D. Al-Watar
doaj   +1 more source

Estrogen Receptor β Agonists Differentially Affect the Growth of Human Melanoma Cell Lines. [PDF]

PLoS ONE, 2015
Cutaneous melanoma is an aggressive malignancy; its incidence is increasing worldwide and its prognosis remains poor. Clinical observations indicate that estrogen receptor β (ERβ) is expressed in melanoma tissues and its expression decreases with tumor ...
Monica Marzagalli, Lavinia Casati, Roberta M Moretti, Marina Montagnani Marelli, Patrizia Limonta   +4 more
doaj   +1 more source

Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation

BMC Pharmacology and Toxicology, 2022
Background Estrogen receptor β (ERβ) is the major ER subtype in hepatic stellate cells (HSCs). Previously we reported phytoestrogen calycosin suppressed liver fibrosis progression and inhibited HSC-T6 cell functions, suggesting the effects may be related
Yaxin Wang, Canyan Wu, Jiahui Zhou, Haiming Fang, Jiajia Wang   +4 more
doaj   +1 more source

Expression of extracellular matrix components is disrupted in the immature and adult estrogen receptor β-null mouse ovary. [PDF]

PLoS ONE, 2012
Within the ovary, Estrogen Receptor β (ERβ) is localized to the granulosa cells of growing follicles. 17β-estradiol (E2) acting via ERβ augments the actions of follicle stimulating hormone in granulosa cells, leading to granulosa cell differentiation and
Alexandra Zalewski, Erin L Cecchini, Bonnie J Deroo   +2 more
doaj   +1 more source