Mapping ERβ genomic binding sites reveals unique genomic features and identifies EBF1 as an ERβ interactor. [PDF]
PLoS ONE, 2013 Considerable effort by numerous laboratories has resulted in an improved understanding of estrogen and SERM action mediated by the two estrogen receptors, ERα and ERβ. However, many of the targets for ERβ in cell physiology remain elusive.
Thien P Le +4 more
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Estrogen receptor β agonist inhibits proliferation of endometrial stromal cells in an estrogen-receptor independent manner [PDF]
Archives of Biological Sciences, 2014 The finding that estrogen receptor ERβ agonists induce regression of ectopic endometrial implants in a rodent model has rekindled interest in the role of ERβ in the growth and maintenance of human endometriosis.
Xia Qiong, Zhao Dong, Wang Juan
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Gene expression of estrogen receptor during different stages of pregnancy in rats model [PDF]
Iraqi Journal of Veterinary SciencesOne essential organ that steroid hormones target is the uterus and ovaries. Many receptors mediate the effects of these hormones such as estrogen receptors ER.
Enas O. Al-Babily, Barra D. Al-Watar
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Estrogen Receptor β Agonists Differentially Affect the Growth of Human Melanoma Cell Lines. [PDF]
PLoS ONE, 2015 Cutaneous melanoma is an aggressive malignancy; its incidence is increasing worldwide and its prognosis remains poor. Clinical observations indicate that estrogen receptor β (ERβ) is expressed in melanoma tissues and its expression decreases with tumor ...
Monica Marzagalli +4 more
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A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
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Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106. [PDF]
, 2016 A collective body of evidence indicates that estrogen protects the heart from myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism remains incompletely understood. We have previously delineated a novel mechanism of how 17β-estradiol
Kim, Jin Kyung, Liu, Han, Luo, Tao
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Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
BMC Biology, 2023 Background Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized.
Madeleine Birgersson +7 more
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Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]
, 2011 The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Bovee, T.F.H. +7 more
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BMC Pharmacology and Toxicology, 2022 Background Estrogen receptor β (ERβ) is the major ER subtype in hepatic stellate cells (HSCs). Previously we reported phytoestrogen calycosin suppressed liver fibrosis progression and inhibited HSC-T6 cell functions, suggesting the effects may be related
Yaxin Wang +4 more
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A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function
Frontiers in Cell and Developmental Biology, 2021 The two homologous estrogen receptors ERα and ERβ exert distinct effects on their cognate tissues. Previous work from our laboratory identified an ERβ-specific phosphotyrosine residue that regulates ERβ transcriptional activity and antitumor function in ...
Bin Yuan +4 more
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