Results 1 to 10 of about 63,057 (294)

The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression

Cell Death and Disease, 2021
Breast cancer has the highest incidence and mortality in women worldwide. There are 70% of breast cancers considered as estrogen receptor α (ERα) positive.
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhenlong Shao, Tumei Hu, Cuifu Yu, Lili Jiang, Jinbao Liu, Hongbiao Huang   +10 more
doaj   +2 more sources

Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα. [PDF]

PLoS ONE
In the DNA complex of coactivator-bound estrogen receptor alpha (ERα), the N-terminal domain (NTD) and C-terminal ligand-binding domain (LBD) interact specifically. ERα-NTD and LBD constitute activation function 1 (AF-1) and activation function 2 (AF-2),
Xiaohui Liu, Miki Shimohigashi, Yasuyuki Shimohigashi   +2 more
doaj   +2 more sources

Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry [PDF]

Journal of Veterinary and Animal Sciences, 2022
The objective of the current study involved assessment of correlation between the expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne neoplasms in 12 postpubertal bitches between 2 to 12 years of age ...
Kodange Omkar Tukaram, Shibu Simon, K. Magnus Paul, C. Jayakumar, I. S. Sajitha, T. Vanesa John   +5 more
doaj   +1 more source

Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2020
Background Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells.
Jin Hwan Lee, Han Kyeom Kim, Bong Kyung Shin   +2 more
doaj   +1 more source

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

Cell, 2021
Summary Estrogen receptor α (ERα) is a hormone receptor and a key driver for over 70% of breast cancers that has been studied for decades as a transcription factor. Unexpectedly, we discover that ERα is a potent non-canonical RNA-binding protein. We show
Yi-Chen Xu, Peiwei Huangyang, Ying Wang, L. Xue, Emily Devericks, Hao G. Nguyen, Xiuyan Yu, J. Oses-Prieto, A. Burlingame, S. Miglani, H. Goodarzi, D. Ruggero   +11 more
semanticscholar   +1 more source

YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis

Nature Communications, 2022
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER+) breast cancer.
Xu Li, Shu Zhuo, Ting Zhuang, Suk-Cho Yong, Guojin Wu, Yu-Chen Liu, K. Mu, Kai Zhang, P. Su, Ying-Zi Yang, Cheng-Cheng Zhang, Jian Zhu, Jin Jiang   +12 more
semanticscholar   +1 more source

Super-enhancer-controlled positive feedback loop BRD4/ERα–RET–ERα promotes ERα-positive breast cancer

Nucleic Acids Research, 2022
Estrogen and estrogen receptor alpha (ERα)-induced gene transcription is tightly associated with ERα-positive breast carcinogenesis. ERα-occupied enhancers, particularly super-enhancers, have been suggested to play a vital role in regulating such ...
Zao-zao Zheng, Lin Xia, Guo-Sheng Hu, Jun-Yi Liu, Ya-hong Hu, Yu-jie Chen, Jia-Yin Peng, Wen-Juan Zhang, Wen Liu   +8 more
semanticscholar   +1 more source

Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis

Nature Communications, 2021
The epithelial to mesenchymal transition (EMT) has been proposed to contribute to the metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a continuum of different EMT states.
Nastaran Mohammadi Ghahhari, Magdalena K. Sznurkowska, N. Hulo, L. Bernasconi, N. Aceto, D. Picard   +5 more
semanticscholar   +1 more source

Effectiveness of Extract Supplements (Apium graveolens L.) to Estrogen Receptors Expression and Oocyte Diameter at Nucleolar Chromatin and Perinucleolar Stages in Female of Nile tilapia (Oreochromis niloticus L.)

Journal of Experimental Life Science, 2023
The study of the use of celery (Apium graveolens L.) in the health sector has been widely discussed. The analysis of the use of celery in the process of oocyte development still needs to be addressed.
Novy Kurnia Rikardo, Agung Pramana Warih Marhendra, Nia Kurniawan, Wibi Riawan, Sri Rahayu   +4 more
doaj   +1 more source

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

Science Advances, 2021
GREB1 is an inducible cytoplasmic glycosyltransferase. What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood.
E. Shin, V. Huynh, Sultan Abda Neja, Chia-yi Liu, A. Raju, K. Tan, N. Tan, J. Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind, V. Tergaonkar   +11 more
semanticscholar   +1 more source