Results 1 to 10 of about 59,872 (242)

HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene [PDF]

MedComm
Estrogen receptor (ER) α is a central regulator of osteoclasts in osteoporosis induced by estrogen deficiency. ERα is regulated through interactions with various coactivators; however, the precise mechanisms of these interactions are not yet fully ...
Junyue Zhang, Yiping Song, Jeong‐Hyun Koo, Si Chen, Kyu Yun Jang, Sun‐Jung Yoon, Jung Ryul Kim, Young Jae Moon   +7 more
doaj   +2 more sources

Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry [PDF]

Journal of Veterinary and Animal Sciences, 2022
The objective of the current study involved assessment of correlation between the expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne neoplasms in 12 postpubertal bitches between 2 to 12 years of age ...
Kodange Omkar Tukaram, Shibu Simon, K. Magnus Paul, C. Jayakumar, I. S. Sajitha, T. Vanesa John   +5 more
doaj   +1 more source

Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma [PDF]

Journal of Pathology and Translational Medicine, 2020
Background Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells.
Jin Hwan Lee, Han Kyeom Kim, Bong Kyung Shin   +2 more
doaj   +1 more source

Effectiveness of Extract Supplements (Apium graveolens L.) to Estrogen Receptors Expression and Oocyte Diameter at Nucleolar Chromatin and Perinucleolar Stages in Female of Nile tilapia (Oreochromis niloticus L.)

Journal of Experimental Life Science, 2023
The study of the use of celery (Apium graveolens L.) in the health sector has been widely discussed. The analysis of the use of celery in the process of oocyte development still needs to be addressed.
Novy Kurnia Rikardo, Agung Pramana Warih Marhendra, Nia Kurniawan, Wibi Riawan, Sri Rahayu   +4 more
doaj   +1 more source

Neuroanatomical association of hypothalamic HSD2-containing neurons with ERα, catecholamines, or oxytocin: implications for feeding? [PDF]

Frontiers in Systems Neuroscience, 2015
This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the α subtype of estrogen receptor (ERα), catecholamines, and/or oxytocin (OT).
Askew, Maegan L., Muckelrath, Halie D., Johnston, Jonathon R., Curtis, Kathleen S.   +3 more
openaire   +3 more sources

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Epigenetics, 2022
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins.
Ruitu Lyu, Xuguo Zhu, Yinghui Shen, Lijun Xiong, Lu Liu, Hang Liu, Feizhen Wu, Christian Argueta, Li Tan   +8 more
doaj   +1 more source

The effect of purple sweet potato (Ipomea batatas L) ethanol extract on Estrogen Receptor Alpha (ERα) and SOD mRNA expression in the menopause-liver animal model

Bali Medical Journal, 2020
Background: Aging and estrogen deficiency in menopause women increase susceptibility to liver diseases. In postmenopausal women, the change of ERα expressions and oxidative stress is related to liver diseases' pathogenesis. Phytoestrogens have been shown to protect and repair the liver organ due to estrogen deficiency.
I Wayan Sugiritama, Ida Ayu Ika Wahyuniari, I Gusti Ayu Dewi Ratnayanti, Ni Made Linawati, I Gusti Nyoman Sri Wiryawan, Ni Luh Gede Yoni Komalasari, I Gusti Kamasan Nyoman Arijana   +6 more
openaire   +1 more source

Role of Estrogen Receptor Alpha rs3798577 Polymorphism in Breast Carcinoma Risk Determination

Indonesian Biomedical Journal, 2022
BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERα polymorphisms, including ERα rs3798577, are reported to be associated with the risk and aggressiveness ...
Pieri Kumaladewi, Wirsma Arif Harahap, Bastian Nova, Irianiwati Widodo, Ramadhan Karsono, Ferry Sandra, Bethy Suryawathy Hernowo   +6 more
doaj   +1 more source

Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant

Breast Cancer Research, 2021
Background Endocrine therapies targeting estrogen signaling have significantly improved breast cancer (BC) patient survival, although 40% of ERα-positive BCs do not respond to those therapies.
Julien Jacquemetton, Loay Kassem, Coralie Poulard, Ahmed Dahmani, Ludmilla De Plater, Elodie Montaudon, Laura Sourd, Ludivine Morisset, Rania El Botty, Sophie Chateau-Joubert, Sophie Vacher, Ivan Bièche, Isabelle Treilleux, Olivier Trédan, Elisabetta Marangoni, Muriel Le Romancer   +15 more
doaj   +1 more source

MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer

Frontiers in Oncology, 2022
Estrogen receptor α (ERα) is the dominant tumorigenesis driver in breast cancer (BC), and ERα-positive BC (ERα+ BC) accounts for more than two-thirds of BC cases.
Xu Zhang, Yang Yang, Danyang Li, Danyang Li, Zhen Wu, Haoyu Liu, Ziyan Zhao, Hongying Zhu, Fei Xie, Xiangzhi Li   +9 more
doaj   +1 more source