Results 11 to 20 of about 63,057 (294)

Ligand dependent gene regulation by transient ERα clustered enhancers

bioRxiv, 2019
Unliganded nuclear receptors have been implicated in ligand-dependent gene regulation. However, the underlying mechanisms are not fully understood. Here we demonstrate that unliganded ERα binds to specific sites in the genome thereby pre-marking them as ...
Bharath Saravanan, Deepanshu Soota, Zubairul Islam, Sudeshna Majumdar, Rajat Mann, Sweety Meel, Umer Farooq, K. Walavalkar, S. Gayen, A. Singh, S. Hannenhalli, D. Notani   +11 more
semanticscholar   +2 more sources

Endocrine Therapy Resistance-Associated ERα-Y537S Mutation Alters ERα/PR Crosstalk in Breast Cancer [PDF]

, 2023
Background: Half of estrogen receptor (ERα)-positive breast cancer patients treated with endocrine therapies manifest intrinsic or acquired therapy resistance.
Huggins, Rosemary Joan
core   +1 more source

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Epigenetics, 2022
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins.
Ruitu Lyu, Xuguo Zhu, Yinghui Shen, Lijun Xiong, Lu Liu, Hang Liu, Feizhen Wu, Christian Argueta, Li Tan   +8 more
doaj   +1 more source

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

Nature Communications, 2021
Breast cancer is now globally the most frequent cancer and leading cause of women’s death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that is initially responsive to antihormonal therapies, but drug ...
P. Munne, Lahja Martikainen, Iiris Räty, Kia Bertula, Nonappa, J. Ruuska, H. Ala-Hongisto, Aino Peura, B. Hollmann, L. Euro, Kerim Yavuz, Linda Patrikainen, Maria Salmela, J. Pokki, Mikko Kivento, J. Väänänen, T. Suomi, Liina Nevalaita, Minna Mutka, P. Kovanen, M. Leidenius, T. Meretoja, K. Hukkinen, O. Monni, J. Pouwels, Biswajyoti Sahu, J. Mattson, H. Joensuu, P. Heikkilä, L. Elo, C. Metcalfe, M. Junttila, O. Ikkala, Juha Klefström   +33 more
semanticscholar   +1 more source

ERα, A Key Target for Cancer Therapy: A Review

OncoTargets and Therapy, 2020
Estrogen receptor α (ERα) is closely associated with both hormone-dependent and hormone-independent tumors, and it is also essential for the development of these cancers.
Yanfang Liu, Hong Ma, Jing Yao
semanticscholar   +1 more source

Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant

Breast Cancer Research, 2021
Background Endocrine therapies targeting estrogen signaling have significantly improved breast cancer (BC) patient survival, although 40% of ERα-positive BCs do not respond to those therapies.
Julien Jacquemetton, Loay Kassem, Coralie Poulard, Ahmed Dahmani, Ludmilla De Plater, Elodie Montaudon, Laura Sourd, Ludivine Morisset, Rania El Botty, Sophie Chateau-Joubert, Sophie Vacher, Ivan Bièche, Isabelle Treilleux, Olivier Trédan, Elisabetta Marangoni, Muriel Le Romancer   +15 more
doaj   +1 more source

OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation

Cell Death and Disease, 2021
Breast cancer is the most common malignancy in women worldwide. Estrogen receptor α (ERα) is expressed in ∼70% of breast cancer cases and promotes estrogen-dependent cancer progression. In the present study, we identified OTU domain-containing 7B (OTUD7B)
Jianing Tang, Zeyu Wu, Zelin Tian, Wei Chen, Gaosong Wu   +4 more
doaj   +1 more source

MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer

Frontiers in Oncology, 2022
Estrogen receptor α (ERα) is the dominant tumorigenesis driver in breast cancer (BC), and ERα-positive BC (ERα+ BC) accounts for more than two-thirds of BC cases.
Xu Zhang, Yang Yang, Danyang Li, Danyang Li, Zhen Wu, Haoyu Liu, Ziyan Zhao, Hongying Zhu, Fei Xie, Xiangzhi Li   +9 more
doaj   +1 more source

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

Cell Communication and Signaling, 2020
Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain.
Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi   +10 more
doaj   +1 more source

Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer. [PDF]

PLoS ONE, 2017
The nuclear transcription factor estrogen receptor α (ERα) plays a critical role in breast cancer progression. ERα acts as an important growth stimulatory protein in breast cancer and the expression level of ERα is tightly related to the prognosis and ...
Juyeon Jeong, Sodam Park, Hyoung-Tae An, Minsoo Kang, Jesang Ko   +4 more
doaj   +1 more source