OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation
Cell Death and Disease, 2021 Breast cancer is the most common malignancy in women worldwide. Estrogen receptor α (ERα) is expressed in ∼70% of breast cancer cases and promotes estrogen-dependent cancer progression. In the present study, we identified OTU domain-containing 7B (OTUD7B)
Jianing Tang +4 more
doaj +1 more source
Oestrogen receptor alpha in pulmonary hypertension [PDF]
, 2015 Aims Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH.
Audrey F. Wright +53 more
core +4 more sources
Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia
Cell Communication and Signaling, 2020 Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain.
Sawako Shindo +10 more
doaj +1 more source
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]
, 2018 Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia +111 more
core +2 more sources
Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer. [PDF]
PLoS ONE, 2017 The nuclear transcription factor estrogen receptor α (ERα) plays a critical role in breast cancer progression. ERα acts as an important growth stimulatory protein in breast cancer and the expression level of ERα is tightly related to the prognosis and ...
Juyeon Jeong +4 more
doaj +1 more source
MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α
Cell Death and Disease, 2021 Breast cancer is the most commonly diagnosed malignant tumor among females. Estrogen receptor α (ERα) is initially expressed in 70% of breast cancers and is a well-known target of endocrine therapy for ERα-positive breast cancer. In the present study, we
Jianing Tang +3 more
doaj +1 more source
Biology, 2023 Estrogens via estrogen receptor alpha (ERα) genomic and nongenomic signaling can influence plasticity processes in numerous brain regions. Using mice that express nuclear only ERα (NOER) or membrane only ERα (MOER), this study examined the effect of ...
Sanoara Mazid +7 more
doaj +1 more source
TRIM16 transcription factor in prostate cancer
Бюллетень сибирской медицины, 2018 The aim of this investigation was to reveal the expression TRIM16, ERα, ERβ and AR in prostate cancer tissues compared to benign hyperplasia and clinical and morphological parameters.Materials and methods.
L. V. Spirina +5 more
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A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. [PDF]
PLoS ONE, 2012 Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is ...
Emily Powell +7 more
doaj +1 more source