Results 11 to 20 of about 43,370 (253)

Endocrine Therapy Resistance-Associated ERα-Y537S Mutation Alters ERα/PR Crosstalk in Breast Cancer [PDF]

, 2023
Background: Half of estrogen receptor (ERα)-positive breast cancer patients treated with endocrine therapies manifest intrinsic or acquired therapy resistance.
Huggins, Rosemary Joan
core   +1 more source

MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer

Frontiers in Oncology, 2022
Estrogen receptor α (ERα) is the dominant tumorigenesis driver in breast cancer (BC), and ERα-positive BC (ERα+ BC) accounts for more than two-thirds of BC cases.
Xu Zhang, Yang Yang, Danyang Li, Danyang Li, Zhen Wu, Haoyu Liu, Ziyan Zhao, Hongying Zhu, Fei Xie, Xiangzhi Li   +9 more
doaj   +1 more source

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

Cell Communication and Signaling, 2020
Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain.
Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi   +10 more
doaj   +1 more source

Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer. [PDF]

PLoS ONE, 2017
The nuclear transcription factor estrogen receptor α (ERα) plays a critical role in breast cancer progression. ERα acts as an important growth stimulatory protein in breast cancer and the expression level of ERα is tightly related to the prognosis and ...
Juyeon Jeong, Sodam Park, Hyoung-Tae An, Minsoo Kang, Jesang Ko   +4 more
doaj   +1 more source

Gene expression of estrogen receptor during different stages of pregnancy in rats model [PDF]

Iraqi Journal of Veterinary Sciences
One essential organ that steroid hormones target is the uterus and ovaries. Many receptors mediate the effects of these hormones such as estrogen receptors ER.
Enas O. Al-Babily, Barra D. Al-Watar
doaj   +1 more source

MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α

Cell Death and Disease, 2021
Breast cancer is the most commonly diagnosed malignant tumor among females. Estrogen receptor α (ERα) is initially expressed in 70% of breast cancers and is a well-known target of endocrine therapy for ERα-positive breast cancer. In the present study, we
Jianing Tang, Yongwen Luo, Guo Long, Ledu Zhou   +3 more
doaj   +1 more source

Both Nuclear and Membrane Estrogen Receptor Alpha Impact the Expression of Estrogen Receptors and Plasticity Markers in the Mouse Hypothalamus and Hippocampus

Biology, 2023
Estrogens via estrogen receptor alpha (ERα) genomic and nongenomic signaling can influence plasticity processes in numerous brain regions. Using mice that express nuclear only ERα (NOER) or membrane only ERα (MOER), this study examined the effect of ...
Sanoara Mazid, Elizabeth M. Waters, Chloe Lopez-Lee, Renata Poultan Kamakura, Batsheva R. Rubin, Ellis R. Levin, Bruce S. McEwen, Teresa A. Milner   +7 more
doaj   +1 more source

Investigating the Erα and Cyclin D1 Gene Expression Levels, Changes in SOD, NO, and MDA Levels, and Histopathology of Mice Testicular Tissue Treated with AFG1

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: Previous studies have shown the adverse effects of aflatoxin G1 on testicular tissue and the process of spermatogenesis. The aim of this study was to investigate changes in the expression of Cyclin D1, the estrogen receptor ERα ...
Toraj Zamir-nasta, Seyran Kakebaraei, Mona Pazhouhi, Cyrus Jalili   +3 more
doaj  

Screening 2‒mercaptoimidazole derivatives for breast cancer treatment

Tạp chí Khoa học và Công nghệ, 2023
2‒Mecaptoimidazole (2MC), its tautomer (2MI), and derivatives were evaluated in silico for their antioxidant activity and potential for breast cancer drug development.
Tran Viet Anh, Huynh Thi Diem Uyen, Le Thi Dieu Huong, Nguyen Quang Trung, Quan V. Vo   +4 more
doaj  

TRIM16 transcription factor in prostate cancer

Бюллетень сибирской медицины, 2018
The aim of this investigation was to reveal the expression TRIM16, ERα, ERβ and AR in prostate cancer tissues compared to benign hyperplasia and clinical and morphological parameters.Materials and methods.
L. V. Spirina, A. К. Gorbunov, I. V. Kondakova, E. М. Slonimskaya, Е. A. Usynin, N. V. Tarasenko   +5 more
doaj   +1 more source