Results 21 to 30 of about 43,370 (253)

Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. [PDF]

PLoS ONE, 2012
Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is ...
Emily Powell, Erin Shanle, Ashley Brinkman, Jun Li, Sunduz Keles, Kari B Wisinski, Wei Huang, Wei Xu   +7 more
doaj   +1 more source

Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1

Frontiers in Oncology, 2021
Estrogen receptor α (ERα) is the major driver for breast tumor carcinogenesis and progression, while ERα positive breast cancer is the major subtype in breast malignancies, which account for 70% breast cancers in patients.
Jianing Ding, Peng Kuang, Peng Kuang
doaj   +1 more source

Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

eLife, 2021
Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action, whereas plasma membrane-located ERα accelerates endothelial healing.
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela CL Garcia, Léa Réthoré, Rana Zahreddine, Morgane Davezac, Chanaelle Fébrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Françoise Lenfant, Coralie Fontaine, Jean-François Arnal, Daniel Henrion   +19 more
doaj   +1 more source

Aptamer-Assisted Detection of the Altered Expression of Estrogen Receptor Alpha in Human Breast Cancer. [PDF]

PLoS ONE, 2016
An increase in the expression of estrogen receptors (ER) and the expanded population of ER-positive cells are two common phenotypes of breast cancer.
Rajesh Ahirwar, Shamsudheen Karuthedath Vellarikkal, Arghya Sett, Sridhar Sivasubbu, Vinod Scaria, Utpal Bora, Bibhuti Bhusan Borthakur, Amal Chandra Kataki, Jagannath Dev Sharma, Pradip Nahar   +9 more
doaj   +1 more source

Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)

, 2020
Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar extent, we ...
Estruch, Ignacio Miro, Rietjens, Ivonne M.C.M., Adam, A.H.B., Louisse, Jochem, de Haan, Laura H.J., Hooiveld, Guido J.E.J., Haan, Laura H.J., de   +6 more
core   +1 more source

ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

npj Breast Cancer, 2022
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions.
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg   +25 more
doaj   +1 more source

The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2012
Introduction Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent estrogen antagonist tamoxifen on
Jiang Zhinong, Guo Junlan, Shen Jianguo, Jin Mei, Xie Shuduo, Wang Linbo   +5 more
doaj   +1 more source

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation

npj Breast Cancer, 2023
The constitutively active ESR1 Y537S mutation is associated with endocrine therapy (ET) resistance and progression of metastatic breast cancer through its effects on estrogen receptor (ERα) gene regulatory functions.
Rosemary J. Huggins, Geoffrey L. Greene
doaj   +1 more source

ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression

, 2012
Many transcription factors undergo transcription-coupled proteolysis. Although ligand binding activates ubiquitin proteolysis of estrogen receptor α (ERα), mechanisms governing this and its relationship to transcriptional activation were unclear.
Zhou, Wen, Slingerland, Joyce M, Sun, Jun, Nawaz, Zafar, Kaliappan, Kosalai   +4 more
core   +1 more source

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer [PDF]

, 2013
Background Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies.
Tollefsbol Trygve O, Patel Shweta N, Chen Huaping, Li Yuanyuan, Hardy Tabitha M, Meeran Syed M   +5 more
core   +1 more source