Results 21 to 30 of about 63,057 (294)
Science Advances, 2020 RING1B co-operates with ERα to regulate estrogen-mediated gene and enhancer activities and chromatin reorganization. RING1B, a core Polycomb repressive complex 1 subunit, is a histone H2A ubiquitin ligase essential for development.
Yusheng Zhang +7 more
semanticscholar +1 more source
MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α
Cell Death and Disease, 2021 Breast cancer is the most commonly diagnosed malignant tumor among females. Estrogen receptor α (ERα) is initially expressed in 70% of breast cancers and is a well-known target of endocrine therapy for ERα-positive breast cancer. In the present study, we
Jianing Tang +3 more
doaj +1 more source
Biology, 2023 Estrogens via estrogen receptor alpha (ERα) genomic and nongenomic signaling can influence plasticity processes in numerous brain regions. Using mice that express nuclear only ERα (NOER) or membrane only ERα (MOER), this study examined the effect of ...
Sanoara Mazid +7 more
doaj +1 more source
The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health.
Endocrinology, 2020 The incidence of chronic disease is elevated in women after menopause. Increased expression of ESR1 (the gene that encodes the estrogen receptor alpha, ERα) in muscle is highly associated with metabolic health and insulin sensitivity.
A. Hevener +3 more
semanticscholar +1 more source
Gene expression of estrogen receptor during different stages of pregnancy in rats model [PDF]
Iraqi Journal of Veterinary SciencesOne essential organ that steroid hormones target is the uterus and ovaries. Many receptors mediate the effects of these hormones such as estrogen receptors ER.
Enas O. Al-Babily, Barra D. Al-Watar
doaj +1 more source
Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1
Frontiers in Oncology, 2021 Estrogen receptor α (ERα) is the major driver for breast tumor carcinogenesis and progression, while ERα positive breast cancer is the major subtype in breast malignancies, which account for 70% breast cancers in patients.
Jianing Ding, Peng Kuang, Peng Kuang
doaj +1 more source
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: Previous studies have shown the adverse effects of aflatoxin G1 on testicular tissue and the process of spermatogenesis. The aim of this study was to investigate changes in the expression of Cyclin D1, the estrogen receptor ERα ...
Toraj Zamir-nasta +3 more
doaj
Screening 2‒mercaptoimidazole derivatives for breast cancer treatment
Tạp chí Khoa học và Công nghệ, 2023 2‒Mecaptoimidazole (2MC), its tautomer (2MI), and derivatives were evaluated in silico for their antioxidant activity and potential for breast cancer drug development.
Tran Viet Anh +4 more
doaj
TRIM16 transcription factor in prostate cancer
Бюллетень сибирской медицины, 2018 The aim of this investigation was to reveal the expression TRIM16, ERα, ERβ and AR in prostate cancer tissues compared to benign hyperplasia and clinical and morphological parameters.Materials and methods.
L. V. Spirina +5 more
doaj +1 more source
Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. [PDF]
PLoS ONE, 2012 Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is ...
Emily Powell +7 more
doaj +1 more source