Results 41 to 50 of about 43,370 (253)
, 2012 the actions of estrogen on the growth of WT-SMCs and CSE-KO-SMCs. A, Blockage of ERs activity reversed estrogen-inhibited cell viability in WT-SMCs. The cells were treated with 10 µM ICI 182780 for 30 min following another 72 h treatment with 100 nM ...
Sarathi Mani (144798) +6 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Tropical Life ScienceBreast cancer's increasing prevalence globally underscores the urgent need for effective and gentle therapies, positioning the exploration of herbal remedies as a critical pursuit. Daruju (Acanthus ilicifolius L.) emerges as a compelling candidate due to
Nuraini Rosyadah +7 more
doaj +1 more source
Ligands specify estrogen receptor alpha nuclear localization and degradation
BMC Cell Biology, 2010 Background The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in the presence of agonists but the impact of different antiestrogens on the
Caze-Subra Stéphanie +3 more
doaj +1 more source
The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression
Cell Death and Disease, 2021 Breast cancer has the highest incidence and mortality in women worldwide. There are 70% of breast cancers considered as estrogen receptor α (ERα) positive.
Xiaohong Xia +10 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
STAT3 physically interacts with ERα.
, 2013 To confirm whether there is a physical interaction between STAT3 and ERα, we transfected 293T cells with FLAG-tagged STAT3-C (2 µg) alone or together with ERα (2 µg). 48 h after transfection, cells were treated with 1 nM E2 for 3 h.
Shanchun Guo (304364) +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α
Neoplasia: An International Journal for Oncology Research, 2020 Breast cancer is the most commonly diagnosed malignancy in female worldwide, over 70% of which are estrogen receptor α (ERα) positive. ERα has a crucial role in the initiation and progression of breast cancer and is an indicator of endocrine therapy ...
Jianing Tang +6 more
doaj +1 more source
AKT regulates ERα protein expression.
, 2013 A. ERα levels determined by western blot are reduced in C4-HI tumors treated with PD98059 or LY294002 administrated as indicated in Figure 1. However, ERα levels are more variable between tumors and not regulated by either inhibitor in C4-HD tumor ...
Virginia Novaro (364554) +5 more
core +1 more source