Results 41 to 50 of about 63,057 (294)

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation

npj Breast Cancer, 2023
The constitutively active ESR1 Y537S mutation is associated with endocrine therapy (ET) resistance and progression of metastatic breast cancer through its effects on estrogen receptor (ERα) gene regulatory functions.
Rosemary J. Huggins, Geoffrey L. Greene
doaj   +1 more source

The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2012
Introduction Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent estrogen antagonist tamoxifen on
Jiang Zhinong, Guo Junlan, Shen Jianguo, Jin Mei, Xie Shuduo, Wang Linbo   +5 more
doaj   +1 more source

Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

Acta Pharmaceutica Sinica B
Although various anti-osteoporosis drugs are available, the limitations of these therapies, including drug resistance and collateral responses, require the development of novel anti-osteoporosis agents.
Qing Zhao, Jun-Jie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, Jiali Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao   +13 more
semanticscholar   +1 more source

KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function

Oncogene, 2018
Estrogen receptor alpha (ERα) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas. These master-regulatory functions of ERα require trans-acting elements
Kinisha Gala, Qing Li, A. Sinha, P. Razavi, M. Dorso, F. Sánchez-Vega, Young Rock Chung, R. Hendrickson, James J. Hsieh, M. Berger, Nikolaus Scultz, A. Pastore, O. Abdel-Wahab, S. Chandarlapaty   +13 more
semanticscholar   +1 more source

ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression

, 2012
Many transcription factors undergo transcription-coupled proteolysis. Although ligand binding activates ubiquitin proteolysis of estrogen receptor α (ERα), mechanisms governing this and its relationship to transcriptional activation were unclear.
Zhou, Wen, Slingerland, Joyce M, Sun, Jun, Nawaz, Zafar, Kaliappan, Kosalai   +4 more
core   +1 more source

Interactions between ERα and DUSP22 / LMW-DSP2 [PDF]

, 2007
In the previous study, we demonstrated the involvement of dual specificity phosphatase 22 (DUSP22 / LMW-DSP2) in regulating the LIF/IL-6/STAT3-mediated signaling pathway.
Sekine, Yuichi, S Imoto, Y Hayakawa, N Aoki, Imoto, Seiyu, Sugiyama, Kenji, T Matsuda, Tsuji, Satoshi, O Ikeda, Ikeda, Osamu, Matsuda, Tadashi, Hayakawa, Yoshihiro, K Sugiyama, Aoki, Naohito, Y Sekine, S Tsuji   +15 more
core   +1 more source

Hippo kinases LATS1/2 control human breast cell fate via crosstalk with ERα

Nature, 2017
Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial and basal
A. Britschgi, Stephan Duss, Sungeun Kim, J. Couto, H. Brinkhaus, S. Koren, Duvini De Silva, K. Mertz, D. Kaup, Z. Varga, H. Voshol, Alexandra Vissières, C. Leroy, Tim C. Roloff, Michael B. Stadler, C. Scheel, L. Miraglia, A. Orth, G. Bonamy, Venkateshwar A. Reddy, M. Bentires‐Alj   +20 more
semanticscholar   +1 more source

Expression of ERα in podocytes.

, 2013
A) Immunocytochemical staining of ERα (red) in cultured murine podocytes with cytoplasmatic and nuclear localization. DAPI was used for nuclear staining (blue), negative control was performed without ERα primary antibody. B) Immunohistochemical detection
Sebastian Kummer (339692), Markus Bettendorf (339700), Lara Vanessa Wegerich (339693), Claus Peter Schmitt (339699), Petra Lehmann (339695), Marie-Luise Gross-Weissmann (339702), Friederike Mueller (339696), Stefanie Jeruschke (281665), Ertan Mayatepek (257547), Annette Seibt (136666), Jun Oh (281667), Nadezda Koleganova (339697), Andrea Peters (339694), Elisabeth Halbenz (339698)   +13 more
core   +1 more source

ERα localization to lysosomes.

, 2014
(A) Growing MCF-7 cells were co-stained with anti-ERα Sp-1 and D-12 antibodies. (B) Growing pc DNA flag ERα -transfected HeLa cells were co-stained with anti-ERα HC-20 and flag antibodies. (C) Western blot analysis of ERα cellular levels in growing MCF-7
Valeria Pesiri (552188), Maria Marino (525018), Filippo Acconcia (208478), Pierangela Totta (231516)   +3 more
core   +1 more source

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer [PDF]

, 2013
Background Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies.
Tollefsbol Trygve O, Patel Shweta N, Chen Huaping, Li Yuanyuan, Hardy Tabitha M, Meeran Syed M   +5 more
core   +1 more source