Results 51 to 60 of about 43,370 (253)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

MiR-222-3p negatively regulates ERα.

, 2014
(A) ERα 3′ UTRs is a target of miR-222-3p. P3′UTR-ERα luciferase constructs, containing a wild type or mutated type ERα 3′ UTRs, were transfected into RL95-2 cells.
Binya Liu (517729), Wen Lu (153883), Bilan Li (428645), Qi Che (517730), Wei Bao (241898), Haifeng Qiu (428644), Xiaoping Wan (428649), Xiaoyue Chen (334717)   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling

Molecular Metabolism, 2020
Objective: Estrogen protects animals from obesity through estrogen receptor α (ERα), partially by inhibiting overeating in animals fed ad libitum. However, the effects of estrogen on feeding behavior in hungry animals remain unclear.
Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean-Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang   +19 more
doaj   +1 more source

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

Frontiers in Oncology, 2022
BackgroundAmong women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all breast cancer subtypes.
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Mahmoud Kassem, Tyler A. Wilson, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Christopher C. Coss, Christopher C. Coss, Chad E. Bennett, Chad E. Bennett, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Daniel G. Stover, Daniel G. Stover, Mathew A. Cherian, Mathew A. Cherian   +27 more
doaj   +1 more source

Osteoprotective Effects of Estrogen in the Maxillary Bone Depend on ERα

, 2016
Estrogen deficiency results in disruption of maxillary alveolar bone microarchitecture. Most of the actions of estrogen in long bones occur via estrogen receptor α (ERα). However, the function of ERα in the maxillary bone has not been defined.
Silva, TA, Dias, GJ, Garlet, GP, Grattan, DR, Wyatt, A, Macari, S, Ajay Sharma, L, Szawka, RE, Knowles, P   +8 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ERα directly mediated PHB mitochondrial-nuclear shuttling.

, 2013
(A and B) ERα mediated PHB mitochondrial-nucleus translocation. PC3 cells were transfected with siRNAs specific to (A) erα or (B) erβ, or NC RNA. Twenty four hours post-transfection, 100 nM of E2 was added to the media for 96h. The PC3 cell mitochondria (
Pei Dong (466716), Fangjian Zhou (194432), Ziling Zhang (501225), Jianye Liu (501224), Shengjie Guo (355110), Lijuan Jiang (501223), Zhuowei Liu (501226), Zhiming Wu (128190)   +7 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins.

PLoS ONE
Cryoelectron microscopy (cryo-EM) clarified the quaternary structure of the DNA complex of coactivator-bound estrogen receptor alpha (ERα), revealing the adjacency of the N-terminal domain (NTD) and C-terminal ligand-binding domain (LBD). ERα-NTD and LBD
Xiaohui Liu, Yutaka Matsuyama, Makiko Sugiyama, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi   +6 more
doaj   +1 more source