Results 51 to 60 of about 63,057 (294)

Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER

Frontiers in Endocrinology, 2019
Estrogen receptors are important regulators of the growth of breast tumors. Three different receptors for estrogens have been identified in breast tumors, two nuclear receptors, ERα and ERβ, and a G-protein coupled estrogen receptor 1 (GPER) that ...
R. Girgert, G. Emons, C. Gründker
semanticscholar   +1 more source

Specificity of ERα deletion in aP2-Cre/ERα females.

, 2014
(A) RT-PCR analysis of total RNA from inguinal adipose tissue, brown adipose tissue (BAT), liver, uterus, hypothalamus, kidney and muscle from ERαflox/flox and aP2-Cre/ERαflox/flox mice.
Marko Matic (381848), Sara H. Windahl (349380), Neil Portwood (225481), Per-Olof Berggren (227948), Karin Dahlman-Wright (40531), Hui Gao (169623), Claes Ohlsson (1924), Jan-Åke Gustafsson (4846), Galyna Bryzgalova (381849), Raoul V. Kuiper (506752), Per Antonson (381850), Patricia Humire (381851)   +11 more
core   +1 more source

Progesterone receptor modulates ERα action in breast cancer. [PDF]

, 2015
Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its ...
Mohammed, Hisham, Hadfield, J, Tilley, Wayne D., Stark, Rory, Launchbury, Rosalind, Rueda, OM, Rueda, Oscar M., Russell, IA, Pugh, M., Serandour, Aurelien A., Launchbury, R, Stingl, J, Hickey, T., Brown, GD, D'Santos, C, Raj, G., Robinson, J., Saadi, Amel, Tarulli, G., Mohammed, H, Brown, G., Bruna, A, Saadi, A, Menon, S., Hadfield, J., Pugh, M, Rueda, O., Russell, I. Alasdair, Silva, Grace, Menon, Suraj, Caldas, C, Tarulli, GA, Perou, CM, Raj, Ganesh V., D’Santos, Clive, Robinson, JLL, Silva, G, Serandour, A., Menon, S, Tarulli, Gerard A., Perou, Charles M., Stark, R., Bruna, A., Hickey, TE, et al., Saadi, A., Perou, C., Brown, Gordon D., Birrell, Stephen N., Bruna, Alejandra, Birrell, SN, D'Santos, C., Stark, R, Stingl, John, Caldas, Carlos, Hadfield, James, Russell, I., Launchbury, R., Mohammed, H., Tilley, WD, Silva, G., Birrell, S., Raj, GV, Robinson, Jessica L. L., Hickey, Theresa E., Carroll, Jason S., Pugh, Michelle, Carroll, JS, Serandour, AAA   +68 more
core   +3 more sources

Ligands specify estrogen receptor alpha nuclear localization and degradation

BMC Cell Biology, 2010
Background The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in the presence of agonists but the impact of different antiestrogens on the
Caze-Subra Stéphanie, Mazaheri Mahta, Kocanova Silvia, Bystricky Kerstin   +3 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines

BMC Cancer, 2009
Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
doaj   +1 more source

17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling

Molecular Metabolism, 2020
Objective: Estrogen protects animals from obesity through estrogen receptor α (ERα), partially by inhibiting overeating in animals fed ad libitum. However, the effects of estrogen on feeding behavior in hungry animals remain unclear.
Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean-Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang   +19 more
doaj   +1 more source

Effect of the dominant negative S554fs-ERα on ERα levels of CarB cells.

, 2013
(A) Wild type and mutant form of ERα. The S554fs-ERα was generated by random chemical mutagenesis of the ERα hormone binding domain (19). (B) Western blot analysis in equally-loaded protein extracts from parental, control vector-transfected (CarB-V) and ...
Vassilis Zoumpourlis (312715), Maria Sideridou (312709), Stella Logotheti (312707), Ioannis Christodoulou (312711), Ioannis Michalopoulos (19337), Dimitra Papaevangeliou (312708), Spiros Vlahopoulos (312714), Katerina Tsimaratou (312710), Katerina Pyrillou (312712), Vassilis Gorgoulis (312713)   +9 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of ERα in

, 2012
the actions of estrogen on the growth of WT-SMCs and CSE-KO-SMCs. A, Blockage of ERs activity reversed estrogen-inhibited cell viability in WT-SMCs. The cells were treated with 10 µM ICI 182780 for 30 min following another 72 h treatment with 100 nM ...
Sarathi Mani (144798), Rui Wang (52434), Christopher Lai (144808), Guangdong Yang (144802), Hongzhu Li (144792), Wei Cao (50866), Lingyun Wu (144811)   +6 more
core   +1 more source