Results 61 to 70 of about 59,872 (242)

Increased Expression of Estrogen Receptor α-36 by Breast Cancer Oncogene IKKε Promotes Growth of ER-Negative Breast Cancer Cells

Cellular Physiology and Biochemistry, 2013
Background/Aims: The expression of estrogen receptor-α (ERα) is one of the most important diagnostic and prognostic factors of breast cancer. Recently, ERα-36 has been identified as a novel variant of ER-α.
Qihong Li, Haiyan Sun, Jingcai Zou, Cheng Ge, Kaitao Yu, Yuan Cao, Quan Hong   +6 more
doaj   +1 more source

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

Frontiers in Oncology, 2022
BackgroundAmong women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all breast cancer subtypes.
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Mahmoud Kassem, Tyler A. Wilson, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Christopher C. Coss, Christopher C. Coss, Chad E. Bennett, Chad E. Bennett, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Daniel G. Stover, Daniel G. Stover, Mathew A. Cherian, Mathew A. Cherian   +27 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]

, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe, C Zhao, CJ Du, D Bakstad, D Farre, D Hartl, D Mullassery, D Xing, DA Turner, DG Spiller, E Kassi, E Munukka, ED Papadimitraki, FA Carvalho, I Caballero, JC Price, JC Price, JH Levine, K Dahlman-Wright, K Paech, KA Zarember, L Ashall, L Bjornstrom, M Junkin, M Lion, M Maggiolini, ME Quaedackers, MF Smith Jr., N Munoz, O Takeuchi, PL Zeitlin, R Galien, RC Dodel, RH Straub, S Ghisletti, S Rakoff-Nahoum, S Reardon, SK Drexler, TK Lee, WH Sun, Y Wang, Z Cai, ZX Shan   +42 more
core   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins.

PLoS ONE
Cryoelectron microscopy (cryo-EM) clarified the quaternary structure of the DNA complex of coactivator-bound estrogen receptor alpha (ERα), revealing the adjacency of the N-terminal domain (NTD) and C-terminal ligand-binding domain (LBD). ERα-NTD and LBD
Xiaohui Liu, Yutaka Matsuyama, Makiko Sugiyama, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi   +6 more
doaj   +1 more source

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Nuclear transparency in quasielastic A(e,e'p): intranuclear cascade versus eikonal approximation [PDF]

, 1997
The problem of nuclear propagation through the nuclear medium in quasielastic A(e,e'p) reactions is discussed in the kinematic range ...
Bianconi, A., Boffi, S., Golubeva, Ye. S., Kondratyuk, L. A., Radici, M.   +4 more
core   +2 more sources

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]

, 2020
According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel, Diaconu, Camelia Cristina, Greabu, Maria, Miricescu, Daniela, Rusu, Ioana Ruxandra, Spinu, Dan, Stanescu, Ana Maria Alexandra, Stefani, Constantin, Totan, Alexandra   +8 more
core   +3 more sources