Results 61 to 70 of about 63,057 (294)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Daruju (Acanthus ilicifolius L.) May Exhibit Anti-Breast Cancer Activity Through Inhibition of Proliferation Regulators: A Computational Study

Journal of Tropical Life Science
Breast cancer's increasing prevalence globally underscores the urgent need for effective and gentle therapies, positioning the exploration of herbal remedies as a critical pursuit. Daruju (Acanthus ilicifolius L.) emerges as a compelling candidate due to
Nuraini Rosyadah, Fairuz Sarah Kamila, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Rahmat Grahadi, Dinia Rizqi Dwijayanti, Nashi Widodo, Siti Mariyah Ulfa   +7 more
doaj   +1 more source

A Regulatory “miRcircuitry” Involving miR221&222 and ERα Determines ERα Status of Breast Cancer Cells [PDF]

, 2009
Estrogen Receptor α (ERα) is the most important diagnostic and prognostic factor in breast cancer. Several lines of evidence have suggested that ERα-negative breast tumors, highly aggressive and non-responsive to hormonal therapy, arise from ERα ...
Di Leva, Gianpiero
core  

Inhibition of Skeletal Metastasis by Ectopic ERα Expression in ERα-Negative Human Breast Cancer Cell Lines [PDF]

, 2007
Some hormone-independent breast cancers lack functional estrogen receptors (ERs) and show evidence of a more aggressive metastatic phenotype. A protective role of the ER has also been suggested in hormoneresistant breast cancer progression. In this study,
Bandyopadhyay, Abhik, Wang, Long, Sun, Lu-Zhe, Abhik Bandyopadhyay, Shiau Hui Chin, Long Wang, Hui Chin, Shiau, Lu-Zhe Sun   +7 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ERα Complexes

Environmental Health Perspectives, 2018
Background: Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that might be harmful to human health. Recently, there has been widespread usage of bisphenol chemicals (BPs), such as bisphenol AF (BPAF) and bisphenol S (BPS), as replacements for ...
Yin Li, L. Perera, Laurel A. Coons, K. A. Burns, J. T. Ramsey, Katherine E. Pelch, R. Houtman, R. van Beuningen, C. Teng, K. Korach   +9 more
semanticscholar   +1 more source

STAT3 physically interacts with ERα.

, 2013
To confirm whether there is a physical interaction between STAT3 and ERα, we transfected 293T cells with FLAG-tagged STAT3-C (2 µg) alone or together with ERα (2 µg). 48 h after transfection, cells were treated with 1 nM E2 for 3 h.
Shanchun Guo (304364), Carmen R. Gomez-Fernandez (304363), Guangdi Wang (304362), Mingli Liu (304361)   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α

Neoplasia: An International Journal for Oncology Research, 2020
Breast cancer is the most commonly diagnosed malignancy in female worldwide, over 70% of which are estrogen receptor α (ERα) positive. ERα has a crucial role in the initiation and progression of breast cancer and is an indicator of endocrine therapy ...
Jianing Tang, Yongwen Luo, Zelin Tian, Xing Liao, Qiuxia Cui, Qian Yang, Gaosong Wu   +6 more
doaj   +1 more source

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex

Molecules and Cells, 2018
SUMMARY Whereas the actions of enhancers in gene transcriptional regulation are well established, roles of JmjC domain-containing proteins in mediating enhancer activation remain poorly understood.
Wei-wei Gao, R. Xiao, Wen-juan Zhang, Yi-ren Hu, Bingling Peng, Wenjuan Li, Yao-hui He, Hai-Feng Shen, Jiancheng Ding, Qi-Xuan Huang, Tian-yi Ye, Ying Li, Zhi-ying Liu, Rong Ding, M. Rosenfeld, Wen Liu   +15 more
semanticscholar   +1 more source