Results 31 to 40 of about 59,872 (242)

Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]

, 2017
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma, Neira, Flavia Judith, Pennacchio, Gisela Erika, Soaje, Marta, Valdez, Susana Ruth   +4 more
core   +1 more source

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]

, 2011
The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Bovee, T.F.H., Gruppen, H., Luijendijk, T.J.C., Mol, L.A.M., Simons, R., The, S.A.M., Verbruggen, M.A., Vincken, J.P.   +7 more
core   +2 more sources

6'-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding [PDF]

, 2020
Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM).
Allen, Matthew R., Berman, Alycia G., Brown, Alexa P., Deosthale, Padmini, Plotkin, Lilian I., Powell, Katherine M., Pulliam, Alexis N., Skaggs, Cayla G., Wallace, Joseph M., Williams, David R.   +9 more
core   +1 more source

ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

npj Breast Cancer, 2022
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions.
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg   +25 more
doaj   +1 more source

Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol. [PDF]

, 2017
Prolactin promotes a variety of cancers by an array of different mechanisms. Here, we have investigated prolactin's inhibitory effect on expression of the cell cycle-regulating protein, p21.
Bustamante, Karissa, Chen, Kuan-Hui Ethan, Nguyen, Vi, Walker, Ameae M   +3 more
core   +1 more source

The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2012
Introduction Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent estrogen antagonist tamoxifen on
Jiang Zhinong, Guo Junlan, Shen Jianguo, Jin Mei, Xie Shuduo, Wang Linbo   +5 more
doaj   +1 more source

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation

npj Breast Cancer, 2023
The constitutively active ESR1 Y537S mutation is associated with endocrine therapy (ET) resistance and progression of metastatic breast cancer through its effects on estrogen receptor (ERα) gene regulatory functions.
Rosemary J. Huggins, Geoffrey L. Greene
doaj   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Additional file 6: Figures S1â S7. of The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

, 2017
Supplementary figures with legends. (DOCX 3897 kb)
Tarallo, Roberta, Giurato, Giorgio, Bruno, Giuseppina, Ravo, Maria, Rizzo, Francesca, Salvati, Annamaria, Ricciardi, Luca, Marchese, Giovanna, Cordella, Angela, Rocco, Teresa, Gigantino, Valerio, Biancamaria Pierri, Cimmino, Giovanni, Milanesi, Luciano, Ambrosino, Concetta, Nyman, Tuula, Nassa, Giovanni, Weisz, Alessandro   +17 more
openaire   +1 more source

KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function [PDF]

, 2018
Estrogen receptor alpha (ER alpha) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas.
Abdel-Wahab, Omar, Berger, Michael, Chandarlapaty, Sarat, Chung, Young Rock, Dorso, Madeline, Gala, Kinisha, Hendrickson, Ronald, Hsieh, James J, Li, Qing, Pastore, Alessandro, Razavi, Pedram, Sanchez-Vega, Francisco, Schultz, Nikolaus, Sinha, Amit   +13 more
core   +2 more sources