Results 31 to 40 of about 63,057 (294)

Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

eLife, 2021
Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action, whereas plasma membrane-located ERα accelerates endothelial healing.
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela CL Garcia, Léa Réthoré, Rana Zahreddine, Morgane Davezac, Chanaelle Fébrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Françoise Lenfant, Coralie Fontaine, Jean-François Arnal, Daniel Henrion   +19 more
doaj   +1 more source

Interfering Role of ERα on Adiponectin Action in Breast Cancer

Frontiers in Endocrinology, 2020
Obesity is characterized by an excess of adipose tissue, due to adipocyte hypertrophy and hyperplasia. Adipose tissue is an endocrine organ producing many bioactive molecules, called adipokines.
G. D. Naimo, L. Gelsomino, S. Catalano, L. Mauro, S. Andò   +4 more
semanticscholar   +1 more source

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells

Science Advances, 2019
Pharmacological inhibition of DOT1L blocks estrogen receptor signaling in breast cancer. Breast cancer (BC) resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor α (ERα) signaling, and ways to block ERα pathway ...
G. Nassa, A. Salvati, Roberta Tarallo, Valerio Gigantino, E. Alexandrova, D. Memoli, Assunta Sellitto, F. Rizzo, D. Malanga, Teresa Mirante, E. Morelli, M. Nees, M. Åkerfelt, Sara Kangaspeska, T. Nyman, L. Milanesi, G. Giurato, A. Weisz   +17 more
semanticscholar   +1 more source

Aptamer-Assisted Detection of the Altered Expression of Estrogen Receptor Alpha in Human Breast Cancer. [PDF]

PLoS ONE, 2016
An increase in the expression of estrogen receptors (ER) and the expanded population of ER-positive cells are two common phenotypes of breast cancer.
Rajesh Ahirwar, Shamsudheen Karuthedath Vellarikkal, Arghya Sett, Sridhar Sivasubbu, Vinod Scaria, Utpal Bora, Bibhuti Bhusan Borthakur, Amal Chandra Kataki, Jagannath Dev Sharma, Pradip Nahar   +9 more
doaj   +1 more source

Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids

Molecular Metabolism, 2019
Objective Among obesity-associated metabolic diseases, non-alcoholic fatty liver disease (NAFLD) represents an increasing public health issue due to its emerging association with atherogenic dyslipidemia and cardiovascular diseases (CVDs).
Clara Meda, M. Barone, N. Mitro, F. Lolli, S. Pedretti, D. Caruso, A. Maggi, S. Della Torre   +7 more
semanticscholar   +1 more source

The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progression

Journal of Cancer, 2020
Breast cancer is one of the most common malignancies worldwide, while the luminal types (ERα positive) accounts for two third of all breast cancer cases.
Zhi-Guo Niu, Xin Li, Su-Yin Feng, Qing-Song Huang, Ting Zhuang, Cheng Yan, Hui Qian, Yinlu Ding, Jian Zhu, Wen-Rong Xu   +9 more
semanticscholar   +1 more source

ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

npj Breast Cancer, 2022
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions.
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg   +25 more
doaj   +1 more source

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

Frontiers in Immunology, 2019
Women have increased prevalence of Th17-mediated autoimmune diseases, including lupus and multiple sclerosis, and severe asthma. While estradiol and progesterone increased IL-17A production in Th17 cells by inhibiting Let7f miRNA expression and ...
Hubaida Fuseini, J. Cephus, Pingsheng Wu, J. Davis, Diana C. Contreras, V. Gandhi, Jeffrey C. Rathmell, D. Newcomb   +7 more
semanticscholar   +1 more source

The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression

Oncogene, 2020
ERα positive breast cancer accounts for 70% of breast malignancies. Compared with ERα negative types, ERα positive breast cancer could be effective controlled by endocrine therapy. However, more than half of the patients will develop endocrine resistance,
Jian Zhu, Xin Li, P. Su, Min Xue, Y. Zang, Yinlu Ding   +5 more
semanticscholar   +1 more source

Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)

, 2020
Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar extent, we ...
Estruch, Ignacio Miro, Rietjens, Ivonne M.C.M., Adam, A.H.B., Louisse, Jochem, de Haan, Laura H.J., Hooiveld, Guido J.E.J., Haan, Laura H.J., de   +6 more
core   +1 more source