Results 21 to 30 of about 17,657 (203)

Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, representing the most aggressive breast cancer (BC) subtype with limited treatment options due to a lack of estrogen receptor alpha (ERα), progesterone receptor (PR), and Erb-B2 ...
Elena Alexandrova, Jessica Lamberti, Pasquale Saggese, Giovanni Pecoraro, Domenico Memoli, Valeria Mirici Cappa, Maria Ravo, Roberta Iorio, Roberta Tarallo, Francesca Rizzo, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Giovanni Nassa, Alessandro Weisz, Giorgio Giurato   +16 more
doaj   +1 more source

Genome-wide DNA methylation differences according to oestrogen receptor beta status in colorectal cancer

Epigenetics, 2019
Involvement of sex hormones in colorectal cancer (CRC) development has been linked to oestrogen receptor β (ERβ). Expression of ERβ is found reduced in tumour tissue and inversely related to mortality. However, mechanisms are not well understood.
Sonja Neumeyer, Odilia Popanda, Dominic Edelmann, Katja Butterbach, Csaba Toth, Wilfried Roth, Hendrik Bläker, Ruijingfang Jiang, Esther Herpel, Cornelia Jäkel, Peter Schmezer, Lina Jansen, Elizabeth Alwers, Axel Benner, Barbara Burwinkel, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude   +17 more
doaj   +1 more source

Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway

Frontiers in Endocrinology, 2020
Endometriosis is an inflammatory gynecological disorder characterized by endometrial tissue growth located outside of the uterine cavity in addition to chronic pelvic pain and infertility.
Dongfang Xiang, Min Zhao, Xiaofan Cai, Yongxia Wang, Lei Zhang, Helen Yao, Min Liu, Huan Yang, Mingtao Xu, Huilin Li, Huijuan Peng, Min Wang, Xuefang Liang, Ling Li, Paul Yao, Paul Yao   +15 more
doaj   +1 more source

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

npj Breast Cancer, 2022
Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities.
Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse   +26 more
doaj   +1 more source

Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor β Repression

Cell Reports, 2015
The role of ERβ in prostate cancer is unclear, although loss of ERβ is associated with aggressive disease. Given that mice deficient in ERβ do not develop prostate cancer, we hypothesized that ERβ loss occurs as a consequence of tumorigenesis caused by ...
Paul Mak, Jiarong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio   +7 more
doaj   +1 more source

Additional file 6: Figures S1â S7. of The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

, 2017
Supplementary figures with legends. (DOCX 3897 kb)
Tarallo, Roberta, Giurato, Giorgio, Bruno, Giuseppina, Ravo, Maria, Rizzo, Francesca, Salvati, Annamaria, Ricciardi, Luca, Marchese, Giovanna, Cordella, Angela, Rocco, Teresa, Gigantino, Valerio, Biancamaria Pierri, Cimmino, Giovanni, Milanesi, Luciano, Ambrosino, Concetta, Nyman, Tuula, Nassa, Giovanni, Weisz, Alessandro   +17 more
openaire   +1 more source

Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta

Molecules, 2017
Phytoestrogens are plant compounds with estrogenic effects found in many foods. We have previously reported phytoestrogen activity of blackcurrant anthocyanins (cyanidin-3-glucoside, cyanidin-3-rutinoside, delphinidin-3-glucoside, and delphinidin-3 ...
Naoki Nanashima, Kayo Horie, Hayato Maeda   +2 more
doaj   +1 more source

Urethral dysfunction in female mice with estrogen receptor β deficiency. [PDF]

PLoS ONE, 2014
Estrogen has various regulatory functions in the growth, development, and differentiation of the female urogenital system. This study investigated the roles of ERβ in stress urinary incontinence (SUI).
Yung-Hsiang Chen, Chao-Jung Chen, Shuyuan Yeh, Yu-Ning Lin, Yang-Chang Wu, Wen-Tsong Hsieh, Bor-Tsang Wu, Wen-Lung Ma, Wen-Chi Chen, Chawnshang Chang, Huey-Yi Chen   +10 more
doaj   +1 more source

ANALISIS IN SILICO GENISTEIN DAN ANALOGNYA SEBAGAI INHIBITOR KANKER PAYUDARA RESEPTOR ESTROGEN ALFA POSITIF (ERα+)

JURNAL FARMASI GALENIKA, 2017
Breast cancer is the highest mortality disease on women in the world and about 60-80% of the cases are ERα+ breast cancer. The discovery of more selective to HERα, safe, and potential new anticancer agent is expected to help the treatment of ERα+ breast cancer.
openaire   +1 more source

Low‐Profile, High‐Gain GRIN RF Lenses via Multi‐Material Vat Photopolymerization

Advanced Functional Materials, EarlyView.
We investigate the opportunity of leveraging multi‐material vat photopolymerization printing to manufacture intricate lenses exhibiting permittivity gradients that can increase signal gain in transmitted radiofrequency signals in the X‐ and Ku‐bands. Lenses produced with more distinct low‐loss materials (up to 5) can deliver an 18 dB signal gain with a
Lawrence Romangsuriat, Alexander Peraire‐Bueno, A. John Hart, Randall M. Erb   +3 more
wiley   +1 more source