Results 41 to 50 of about 22,519 (238)

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Estrogen receptor β exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib. [PDF]

PLoS ONE, 2010
BACKGROUND: The role of estrogen and estrogen receptors in oncogenesis has been investigated in various malignancies. Recently our group identified estrogen receptor beta (ERβ) expression as an independent prognostic factor in the progression of human ...
Giulia Pinton, Warren Thomas, Paolo Bellini, Arcangela Gabriella Manente, Roberto E Favoni, Brian J Harvey, Luciano Mutti, Laura Moro   +7 more
doaj   +1 more source

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

Frontiers in Oncology, 2022
BackgroundAmong women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all breast cancer subtypes.
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Mahmoud Kassem, Tyler A. Wilson, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Christopher C. Coss, Christopher C. Coss, Chad E. Bennett, Chad E. Bennett, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Daniel G. Stover, Daniel G. Stover, Mathew A. Cherian, Mathew A. Cherian   +27 more
doaj   +1 more source

Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates

Indonesian Journal of Cancer
Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer ...
Novyananda Salmasfattah, Binar Asrining Dhiani, Faisal Akhmal Muslikh, Galih Satrio Putra   +3 more
openaire   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Estrogen receptor β exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity.

PLoS ONE, 2020
Estrogen receptor β (ERβ) was first identified in the rodent prostate and is abundantly expressed in human and rodent prostate epithelium, stroma, immune cells and endothelium of the blood vessels.
Surendra Chaurasiya, Scott Widmann, Cindy Botero, Chin-Yo Lin, Jan-Åke Gustafsson, Anders M Strom   +5 more
doaj   +1 more source

Distances between BPA and ERβ.

, 2013
Distances between BPA and ERβ.
Charlie Chandsawangbhuwana (31494), Michael E. Baker (27422)   +1 more
core   +1 more source

β‐Ketonitrile‐Modified Prodan Derivatives as Large‐Stokes‐Shift Solvatochromic Fluorophores With Enhanced Brightness and Ratiometric Thermometric Response

Chemistry – A European Journal, EarlyView.
We report a systematic study of β‐ketonitrile–modified Prodan‐type solvatochromic fluorophores. The β‐ketonitrile substitution induces marked bathochromic shifts in absorption and emission and significantly enhances fluorescence quantum yields in nonpolar solvents.
Hiroaki Asakawa, Takuya Tanaka, Kensei Konishi, Gen‐ichi Konishi   +3 more
wiley   +1 more source

Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality

, 2018
Estrogen receptor (ER) β has growth inhibitory and chemo drug potentiating effect on ovarian cancer cells. We studied the dependence of ERβ function on the presence of KDM6B and SIRT1 in human ovarian cancer cells in vitro.
Giulia Pinton, Nilsson, S, Stefan Nilsson, Laura Moro, Pinton, G, Moro, L   +5 more
core   +1 more source