Results 31 to 40 of about 29,801 (212)

Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway

Frontiers in Endocrinology, 2020
Endometriosis is an inflammatory gynecological disorder characterized by endometrial tissue growth located outside of the uterine cavity in addition to chronic pelvic pain and infertility.
Dongfang Xiang, Min Zhao, Xiaofan Cai, Yongxia Wang, Lei Zhang, Helen Yao, Min Liu, Huan Yang, Mingtao Xu, Huilin Li, Huijuan Peng, Min Wang, Xuefang Liang, Ling Li, Paul Yao, Paul Yao   +15 more
doaj   +1 more source

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]

, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe, C Zhao, CJ Du, D Bakstad, D Farre, D Hartl, D Mullassery, D Xing, DA Turner, DG Spiller, E Kassi, E Munukka, ED Papadimitraki, FA Carvalho, I Caballero, JC Price, JC Price, JH Levine, K Dahlman-Wright, K Paech, KA Zarember, L Ashall, L Bjornstrom, M Junkin, M Lion, M Maggiolini, ME Quaedackers, MF Smith Jr., N Munoz, O Takeuchi, PL Zeitlin, R Galien, RC Dodel, RH Straub, S Ghisletti, S Rakoff-Nahoum, S Reardon, SK Drexler, TK Lee, WH Sun, Y Wang, Z Cai, ZX Shan   +42 more
core   +5 more sources

Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor β Repression

Cell Reports, 2015
The role of ERβ in prostate cancer is unclear, although loss of ERβ is associated with aggressive disease. Given that mice deficient in ERβ do not develop prostate cancer, we hypothesized that ERβ loss occurs as a consequence of tumorigenesis caused by ...
Paul Mak, Jiarong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio   +7 more
doaj   +1 more source

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

npj Breast Cancer, 2022
Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities.
Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse   +26 more
doaj   +1 more source

Additional file 6: Figures S1â S7. of The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

, 2017
Supplementary figures with legends. (DOCX 3897 kb)
Tarallo, Roberta, Giurato, Giorgio, Bruno, Giuseppina, Ravo, Maria, Rizzo, Francesca, Salvati, Annamaria, Ricciardi, Luca, Marchese, Giovanna, Cordella, Angela, Rocco, Teresa, Gigantino, Valerio, Biancamaria Pierri, Cimmino, Giovanni, Milanesi, Luciano, Ambrosino, Concetta, Nyman, Tuula, Nassa, Giovanni, Weisz, Alessandro   +17 more
openaire   +1 more source

Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]

, 2020
To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald R, Isaacson, Dylan, Li, Yi, Overland, Maya, Sinclair, Adriane   +6 more
core  

Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]

, 2018
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie, Frump, Andrea L., Lahm, Tim, Petrache, Irina, Selej, Mona, Wood, Jordan A., Yakubov, Bakhtiyor   +6 more
core   +1 more source

The Anti-Proliferative Effect of Genistein on Antioxidant System, Cell Proliferation, and Apoptosis: Implications for Hormone-Refractory Prostate Cancer Therapy

Ankara Üniversitesi Tıp Fakültesi Mecmuası
Objectives: This study aims to examine the effect of different genistein concentrations on apoptosis, estrogen receptor beta, and manganese superoxide dismutase (MnSOD) protein expressions in PC3 hormone-resistant metastatic prostate cancer cell lines ...
Nur Özten Kandaş
doaj   +1 more source

Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta

Molecules, 2017
Phytoestrogens are plant compounds with estrogenic effects found in many foods. We have previously reported phytoestrogen activity of blackcurrant anthocyanins (cyanidin-3-glucoside, cyanidin-3-rutinoside, delphinidin-3-glucoside, and delphinidin-3 ...
Naoki Nanashima, Kayo Horie, Hayato Maeda   +2 more
doaj   +1 more source

Urethral dysfunction in female mice with estrogen receptor β deficiency. [PDF]

PLoS ONE, 2014
Estrogen has various regulatory functions in the growth, development, and differentiation of the female urogenital system. This study investigated the roles of ERβ in stress urinary incontinence (SUI).
Yung-Hsiang Chen, Chao-Jung Chen, Shuyuan Yeh, Yu-Ning Lin, Yang-Chang Wu, Wen-Tsong Hsieh, Bor-Tsang Wu, Wen-Lung Ma, Wen-Chi Chen, Chawnshang Chang, Huey-Yi Chen   +10 more
doaj   +1 more source