Results 61 to 70 of about 29,801 (212)

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Breast Cancer Research, 2017
Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors.
Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas   +8 more
doaj   +1 more source

ERβ overexpression may not be a direct prognostic factor in patients with NSCLC: A meta-analysis

The International Journal of Biological Markers, 2022
Overall survival of non-small cell lung cancer (NSCLC) patients remains disappointingly low. The estrogen receptor (ER) was considered a promising therapeutic target for NSCLC.
Hui Li, Haishegn Chen, Jing Shi, Qing Fan, Zhongxia Zhou, Xiufeng Tang, Yanhong Wang, Yuguo Liu   +7 more
doaj   +1 more source

On the Comovement of Contango and Backwardation Across Futures Commodity Markets

Journal of Futures Markets, EarlyView.
ABSTRACT We examine the time‐varying nature of the comovement of the slope of the futures curve in major agricultural, metals and energy commodity futures markets in a Global Vector Autoregressive model. We find significant comovement between the slopes, indicating the co‐existence of backwardation and contango in many seemingly unrelated commodity ...
Angelo Luisi, Francesco Roccazzella, Athanasios Triantafyllou   +2 more
wiley   +1 more source

Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

BMC Genomics, 2011
Background Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype of breast cancer (BC).
Papa Maria, Nassa Giovanni, Ferraro Lorenzo, De Filippo Maria, Cicatiello Luigi, Ravo Maria, Giurato Giorgio, Mutarelli Margherita, Grober Oli MV, Paris Ornella, Tarallo Roberta, Luo Shujun, Schroth Gary P, Benes Vladimir, Weisz Alessandro   +14 more
doaj   +1 more source

Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer. [PDF]

PLoS ONE, 2012
Ovarian cancer is the gynecological cancer exhibiting the highest morbidity and improvement of treatments is still required. Previous studies have shown that Estrogen-receptor beta (ERβ) levels decreased along with ovarian carcinogenesis.
Carine Bossard, Muriel Busson, David Vindrieux, Françoise Gaudin, Véronique Machelon, Madly Brigitte, Carine Jacquard, Arnaud Pillon, Patrick Balaguer, Karl Balabanian, Gwendal Lazennec   +10 more
doaj   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions

Frontiers in Endocrinology, 2022
The two estrogen receptors ERα and ERβ are nuclear receptors that bind estrogen (E2) and function as ligand-inducible transcription factors. They are homologues and can form dimers with each other and bind to the same estrogen-response element motifs in ...
Dandan Song, Dandan Song, Huan He, Huan He, Rajitha Indukuri, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosén, Chunyan Zhao, Cecilia Williams, Cecilia Williams   +13 more
doaj   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, EarlyView.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

Genome Biology, 2017
Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing ...
Roberta Tarallo, Giorgio Giurato, Giuseppina Bruno, Maria Ravo, Francesca Rizzo, Annamaria Salvati, Luca Ricciardi, Giovanna Marchese, Angela Cordella, Teresa Rocco, Valerio Gigantino, Biancamaria Pierri, Giovanni Cimmino, Luciano Milanesi, Concetta Ambrosino, Tuula A. Nyman, Giovanni Nassa, Alessandro Weisz   +17 more
doaj   +1 more source