Results 61 to 70 of about 22,519 (238)

Liquiritigenin selectively binds to ERβ.

, 2013
Competitive ER binding using human recombinant A) ERα and B) ERβ.
Jeffrey R. Anderson (198988), Birgit M. Dietz (433364), Guido F. Pauli (433365), Richard B. van Breemen (433366), Yang Yuan (181384), Dejan Nikolić (433363), Judy L. Bolton (194650), Charlotte Simmler (238586), Atieh Hajirahimkhan (433361), Shao-Nong Chen (433362)   +9 more
core   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

ERβ overexpression may not be a direct prognostic factor in patients with NSCLC: A meta-analysis

The International Journal of Biological Markers, 2022
Overall survival of non-small cell lung cancer (NSCLC) patients remains disappointingly low. The estrogen receptor (ER) was considered a promising therapeutic target for NSCLC.
Hui Li, Haishegn Chen, Jing Shi, Qing Fan, Zhongxia Zhou, Xiufeng Tang, Yanhong Wang, Yuguo Liu   +7 more
doaj   +1 more source

ERβ ligands trigger cytoplasmic-to-nuclear translocation of ERβ and induce its transcriptional acitivity in BLM melanoma cells.

, 2015
(A) Immunofluorescence assay of ERβ intracellular localization. In control BLM melanoma cells, ERβ is mainly localized at the cytoplasmic level. Treatment of the cells with either DPN or E2 (10−8 M, for 24 h) induces ERβ translocation into the nucleus. A
Lavinia Casati (777403), Marina Montagnani Marelli (549970), Patrizia Limonta (549974), Monica Marzagalli (549973), Roberta M. Moretti (549969)   +4 more
core   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited.
Jorine Arnouts, Léon C. van Kempen, Senada Koljenović, Helena Oliveres, Pieterjan Vanclooster, Hans Prenen, Caro De Weerdt, Siddharth Chhajlani, Geert Roeyen, Laure Sorber, Koen De Winne, Jonas Dahnoun, Greetje Vanhoutte, Timon Vandamme, Karen Zwaenepoel   +14 more
wiley   +1 more source

Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

BMC Genomics, 2011
Background Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype of breast cancer (BC).
Papa Maria, Nassa Giovanni, Ferraro Lorenzo, De Filippo Maria, Cicatiello Luigi, Ravo Maria, Giurato Giorgio, Mutarelli Margherita, Grober Oli MV, Paris Ornella, Tarallo Roberta, Luo Shujun, Schroth Gary P, Benes Vladimir, Weisz Alessandro   +14 more
doaj   +1 more source

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

Hippocampal mRNA expression of ERα, ERβ, and GPR30 and the ERα/ERβ mRNA ratio.

, 2013
A: No significant difference was observed among all rats. B: ERβ mRNA expression showed no significant difference among all groups. C: GPR30 mRNA expression showed no significant difference among all groups.
Linghong Liao (450994), Shujiao Chen (450992), Jie Yu (150626), Hiroki Namba (211039), Kenji Sugiyama (450997), Candong Li (450998), Jianying Shen (450996), Shanshan Ding (114839), Lingyuan Zhang (450995), Tetsuya Asakawa (450993)   +9 more
core   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source