Results 71 to 80 of about 29,801 (212)

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, EarlyView.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer

Cell Death and Disease, 2023
Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor β (ERβ). However, clinical strategies for CRC therapy associated with ERβ are still under investigation.
Tianqi Liu, Min Zhao, Lin Peng, Jiangbo Chen, Pu Xing, Pin Gao, Lei Chen, Xiaowen Qiao, Zaozao Wang, Jiabo Di, Hong Qu, Beihai Jiang, Xiangqian Su   +12 more
doaj   +1 more source

Preliminary investigation of the influence of long-term dietary isoflavone intake on reproductive tract histology and sex steroid receptor expression in female domestic cats (Felis catus) [PDF]

, 2012
Genistein and daidzein are isoflavones which are reported to influence the reproductive system in a variety of mammalian species. This pilot study aimed to determine if dietary isoflavones could potentially influence reproductive tract histology or ...
Cave, NJ, Roe, WD, Thomas, DG, Ugarte, CE, Whitehouse-Tedd, KM   +4 more
core   +1 more source

Machine learning‐based prediction of large‐for‐gestational‐age neonates in diabetic and non‐diabetic pregnancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study determines whether a machine‐learning model integrating sonographic biometry with maternal clinical parameters improves prediction of large‐for‐gestational‐age (LGA) compared with Hadlock's EFW formula. Methods We conducted a retrospective cohort study including all singleton live births at ≥32 gestational weeks at a ...
Ohad Houri, Asaf Romano, Asnat Walfisch, Eran Hadar, Yinon Gilboa, Leor Perl, Nadav Loebl, Ron Unger   +7 more
wiley   +1 more source

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia [PDF]

, 2018
Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment.
Bellini, Maria Jose, Capani, Francisco, Garcia Segura, Luis Miguel, Saraceno, Gustavo Ezequiel   +3 more
core   +2 more sources

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2017
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core  

Estrogen receptor β signalling in mammary epithelial and breast cancer cells [PDF]

, 2010
Estrogens are key players in the etiology and progression of breast cancer, and mediate their effects through the estrogen receptors (ERα and ERβ). ERα plays important roles in proliferation and progression of breast cancer, whereas a distinct function ...
Lindberg, Karolina
core   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

甲状腺乳头状癌雌激素受体β表达及其 5′非翻译区甲基化

Zhongshan Daxue xuebao. Yixue kexue ban, 2020
【目的】研究甲状腺乳头状癌（PTC）中雌激素受体β基因（ERβ）表达及 5′非翻译区甲基化状态，探讨ERβ在 PTC 中低表达的原因。【方法】应用 Western blot 和免疫组织化学染色法检测正常甲状腺细胞Nthy-ori3-1、PTC 细胞 BCPAP 以及正常甲状腺组织、甲状腺结节性增生组织和 PTC 组织ERβ蛋白表达；应用 qRT-PCR 检测各细胞和组织中 ERβ mRNA（0K-1）、ERβ mRNA（0N-1）和总 ERβ mRNA 表达水平；亚硫酸氢盐测序分析各细胞和组织中 ERβ
苟茜, 许琳婉, 刘智敏
doaj