Results 71 to 80 of about 17,657 (203)

Comparative study of estrogen receptor α, β mRNA expressions of endometriosis and normal endometrium in women and analysis of potential synthetic anti-estrogens in silico

Journal of Biological Research, 2018
Endometriosis is a multifactorial disease in which genetic and environmental factors interact causing its pathogenesis. The aim of this study was to investigate the expression pattern of estrogen receptor α (ERα) and β (ERβ) in endometriosis patients ...
Eldafira Eldafira, Abinawanto Abinawanto, Luthfiralda Sjahfirdi, Asmarinah Asmarinah, Purnomo Soeharso, Muharam Muharam, Vivitri D. Prasasty, Dwi A. Pujianto   +7 more
doaj   +1 more source

Navigating Ethical Review Processes in Conflict‐Affected, Authoritarian Contexts: A Case Study of Myanmar's Interim Ethics Review Board (IERB)

Asia Pacific Viewpoint, EarlyView.
ABSTRACT This article examines the formation and operation of Myanmar's Interim Ethics Review Board (IERB), which was established in November 2023 by displaced academics involved in the Civil Disobedience Movement against the 2021 military coup. Operating within a highly repressive, conflict‐ridden environment, the IERB exemplifies a locally‐led and ...
Phyu Phyu Thin Zaw, Su Su Maw, Nyein Chan, The Spring IERB Team   +3 more
wiley   +1 more source

Conversion of a selective ERβ agonist into a potent antagonist via long-chain derivatization

Results in Chemistry
Estrogen receptor β (ERβ) is overexpressed in certain cancers, including triple-negative breast cancer (TNBC), and has context-dependent roles that can promote or suppress tumor progression. To explore its therapeutic potential, we designed WC10, a novel
Takuji Shoda, Moena Tsuda, Naoya Hirata, Hideshi Inoue, Yasunari Kanda, Yosuke Demizu   +5 more
doaj   +1 more source

Health Insurance Coverage and Rural–Urban Differences in Maternal Health Care Among Postpartum Women—National Health Interview Survey

Birth, EarlyView.
Are there rural–urban differences in maternal health and care among postpartum women, and do those differences vary by insurance coverage? This study used the 2013–2018 National Health Interview Surveys of 2,664 non‐pregnant female respondents ages 18–49 with an infant under age one.
Julia D. Interrante, Alyssa H. Fritz, Sara C. Handley, Clara E. Busse, Katy B. Kozhimannil   +4 more
wiley   +1 more source

Comparative atrial fibrillation risk across Bruton's tyrosine kinase inhibitors in B‐cell malignancies: A nationwide population‐based study

British Journal of Haematology, EarlyView.
Real‐world nationwide data in B‐cell malignancies reveal a markedly increased 1‐year incidence of hospitalized atrial fibrillation with ibrutinib compared with second‐generation Bruton's tyrosine kinase inhibitors and venetoclax, arguing for closer cardiac surveillance.
Yoann Zelmat, Loic Ysebaert, Paul Gautier, Agnes Sommet, Margaux Lafaurie, Fabien Despas   +5 more
wiley   +1 more source

Not that different after all: Pro‐environmental social norms predict pro‐environmental behaviour (also) among those believing in conspiracy theories

British Journal of Psychology, EarlyView.
Abstract Social norms are powerful predictors of pro‐environmental behaviour. At the same time, conspiracy beliefs are prevalent that can reduce individuals' efforts to act pro‐environmentally and might impede the influence of social norms. Across three cross‐sectional studies in three countries (Germany, UK, US; total N = 1037), we investigated the ...
Kevin Winter, Lotte Pummerer, Kai Sassenberg   +2 more
wiley   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, EarlyView.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Centering geospatial data uncertainty and the potential for injustice in pastoralist rangeland conservation prioritization

Conservation Biology, EarlyView.
Abstract Procedural, distributional, recognitional, and epistemic justice aspects of conservation interventions are well documented in contexts where pastoralism is a key livelihood and way of life. Geospatial analyses and representations of wildlife conservation and restoration that are increasingly applied in pastoralist rangeland socioecological ...
Ryan R. Unks
wiley   +1 more source