Results 81 to 90 of about 22,519 (238)

Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer

, 2016
Unlike estrogen receptor α (ERα) that predominantly promotes hormone-dependent breast tumor growth, ERβ exhibits antitumor effects in a variety of cancer types.
Rong Li, Gupta, Harshita B., Pei Wang, Vadlamudi, Ratna, Yuan, Bin, Huai-Chin Chiang, Qinong Ye, Harshita B. Gupta, Gangadhara R. Sareddy, Tyler J. Curiel, Cheng, Long, Bin Yuan, Ratna Vadlamudi, Gupta, Kshama, Elledge, Richard, Li, Rong, Kate Lathrop, Ye, Qinong, Kshama Gupta, Stanton McHardy, McHardy, Stanton, Curiel, Tyler J., Wang, Degeng, Long Cheng, Richard Elledge, Hu, Yanfen, Lathrop, Kate, Chiang, Huai Chin, Sareddy, Gangadhara R., Wang, Pei, Degeng Wang, Yanfen Hu   +31 more
core   +1 more source

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage

Cellular Physiology and Biochemistry, 2015
Background/Aims: The risk of heart disease is higher in males than in females. However, this advantage of females declines with increasing age, presumably a consequence of decreased estrogen secretion and malfunctioning of the estrogen receptor.
Dennis Jine-Yuan Hsieh, Wei-Wen Kuo, Yi-Ping Lai, Marthandam Asokan Shibu, Chia-Yao Shen, Peiying Pai, Yu-Lan Yeh, Jing-Ying Lin, Vijaya Padma Viswanadha, Chih-Yang Huang   +9 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Estrogen receptor β deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells

Redox Biology
The incidence of ulcerative colitis (UC) is significantly higher among individuals with colonic estrogen receptor β (ERβ) deficiency, such as postmenopausal women, but the involvement of ERβ deficiency in UC pathogenesis remains obscure.
Yilei Guo, Yue He, Yanrong Zhu, Wenjie Zhang, Haochang Lin, Mianjiang Zhao, Jiafeng Zhang, Yawen Bai, Zhifeng Wei, Yufeng Xia, Yue Dai   +10 more
doaj   +1 more source

Do good neighbours compensate for bad climate? The case of sessile oak Quercus petraea in phylogenetically distant neighbourhoods

Oikos, EarlyView.
Stressful climates threaten the performance of individuals and the survival of species, but individual performance also depends on biotic interactions with neighbours, so that ‘good' neighbours might in theory compensate for ‘bad' climates. However, what makes a good neighbour, and why, has been little studied.
Keliang Zhang, Vincent Jung, Maud Deniau, Benjamin Yguel, Benoît Béchade, Soumen Mallick, Miguel Verdú, Andreas Prinzing   +7 more
wiley   +1 more source

ERΒ is a possible biomarker of breast cancer

Breast cancer (BC) is the most common cancer among women worldwide. The diagnosis and treatment decisions depend on the three biomarkers: oestrogen receptor alfa, progesterone receptor and human epidermal growth factor 2.
Jovanović-Ćupić, Snežana, Božović, Ana, Nedeljković, Milica, Krajnović, Milena, Kožik, Bojana, Todorović, Lidija, Mandušić, Vesna, Kokanov, Nikola   +7 more
core   +5 more sources

Conversion of a selective ERβ agonist into a potent antagonist via long-chain derivatization

Results in Chemistry
Estrogen receptor β (ERβ) is overexpressed in certain cancers, including triple-negative breast cancer (TNBC), and has context-dependent roles that can promote or suppress tumor progression. To explore its therapeutic potential, we designed WC10, a novel
Takuji Shoda, Moena Tsuda, Naoya Hirata, Hideshi Inoue, Yasunari Kanda, Yosuke Demizu   +5 more
doaj   +1 more source

Molecular mechanisms of estrogen receptor -induced apoptosis and autophagy in tumors: implication for treating osteosarcoma

Journal of International Medical Research, 2019
The estrogen receptors α (ERα) and β (ERβ) are located in the nucleus and bind to estrogen to initiate transcription of estrogen-responsive genes. In a variety of tumor cells, ERβ has been shown to be a tumor suppressor.
Zheng-ming Yang, Min-fei Yang, Wei Yu, Hui-min Tao   +3 more
doaj   +1 more source

Expression of AR, ERα, and ERβ in breast cancer and RCC cell lines, and the expression of ERα and ERβ in kidney, RCC, and breast cancer tissue samples.

, 2013
(A) (B) In breast cancer cell lines, MCF-7 showed AR, ERα, and ERβ expression, while HBL100 showed no ERα expression and only low ERβ expression. In RCC cell lines, no AR expression was observed.
Cheng-Ping Yu (127145), Guang-Huan Sun (383119), Yi-Ting Huang (383118), Dah-Shyong Yu (127126), Jar-Yi Ho (17656), Ren-Jun Hsu (127121), Tai-Lung Cha (127124), Shu-Pin Chen (383121), Fung-Wei Chang (383120)   +8 more
core   +1 more source