Results 81 to 90 of about 17,657 (203)

A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

Heliyon
In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER ...
Derek A. Abbott, Maureen G. Mancini, Michael J. Bolt, Adam T. Szafran, Kaley A. Neugebauer, Fabio Stossi, Daniel A. Gorelick, Michael A. Mancini   +7 more
doaj   +1 more source

Strategic conservation prioritization through creating and updating the regional species of greatest conservation need list in the northeastern United States

Conservation Science and Practice, EarlyView.
Biodiversity is declining globally, underscoring the need for conservation strategies informed by regional expertise. In the northeastern United States, 14 state wildlife agencies and taxonomic experts developed the Regional Species of Greatest Conservation Need (RSGCN) list, revealing that global and national datasets captured only ~55% of regionally ...
Melissa D. Starking, Tracy Monegan Rice, Karen Terwilliger, Donovan Drummey, Mack Frantz, Catherine D. Haffner, Brian Hess, Lisa Holst, Michael Marchand, Kevin R. Burgio   +9 more
wiley   +1 more source

Descrição atualizada da paralisia cerebral

Developmental Medicine &Child Neurology, EarlyView.
Resumo A paralisia cerebral (PC) é um termo descritivo amplamente utilizado para um espectro de deficiências motoras causadas por lesão ou malformação cerebral não progressiva ocorrida durante as fases iniciais do desenvolvimento. Avanços recentes nas áreas da genética, de pesquisa em inflamação e em neurofisiologia têm refinado a compreensão ...
Bernard Dan, Peter Rosenbaum, Lucinda Carr, Martin Gough, John Coughlan, Nonyelum Nweke   +5 more
wiley   +1 more source

Obesity Suppresses Estrogen Receptor Beta Expression in Breast Cancer Cells via a HER2-Mediated Pathway.

PLoS ONE, 2015
Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen receptor beta (ERβ) expression is correlated with improved therapy response and survival.
Laura W Bowers, Megan Wiese, Andrew J Brenner, Emily L Rossi, Rajeshwar R Tekmal, Stephen D Hursting, Linda A deGraffenried   +6 more
doaj   +1 more source

Inducible tomato defences persist in detached leaves, despite differential plant variety and gene‐dependent expression

Ecological Entomology, EarlyView.
Short‐ and long‐term expression of PPO‐D, PI‐IIc and PR‐1a were assessed in intact plants and detached tomato leaves of two varieties infested with Tetranhycus urticae. Tomato defences were induced in both intact and detached leaves, but the induction levels varied with plant variety and gene assessed.
Mariya Kozak, Diogo P. Godinho, Eren Yayla, Juan Adánez, Inês Fragata, Sara Magalhães, Leonor R. Rodrigues   +6 more
wiley   +1 more source

Spanish stock returns, growth, and inflation, 1900–2020

The Economic History Review, EarlyView.
Abstract This paper studies equity returns in the Madrid Stock Exchange and their connections with the macroeconomy from the emergence of a stock market around 1900 to its ‘big bang’ at the turn of the twenty‐first century. Using high‐quality data from primary sources and the methodology of the modern IBEX35 (published since 1987), we constructed an ...
Stefano Battilossi, Stefan O. Houpt, Miguel Artola Blanco   +2 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Facilitation of mucosal healing by estrogen receptor β in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells

Acta Pharmaceutica Sinica B
Colonic mucosal healing is the ultimate goal of ulcerative colitis (UC) treatment, but it remains difficult to realize. Given the higher incidence of UC in males and the beneficial effect of estrogen on UC, we conducted this study to examine the ...
Yilei Guo, Yanrong Zhu, Jing Zhang, Yue He, Mianjiang Zhao, Haochang Lin, Zhifeng Wei, Yufeng Xia, Yue Dai   +8 more
doaj   +1 more source

Circadian Deregulation in Multiple Myeloma: BMAL1/CLOCK Expression Patterns and Diagnostic Performance

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak, Mustafa Ertan Ay, Anıl Tombak, Kenan Çevik, Özlem İzci Ay, Tuba Kabasakal, Mehmet Emin Erdal   +6 more
wiley   +1 more source

Mental disorders in childhood or adolescence and subsequent comprehensive school achievement

Journal of Child Psychology and Psychiatry, EarlyView.
Background Childhood mental disorders are associated with poorer school achievement, with potential negative long‐term socio‐economic consequences, but few large‐scale studies have examined this association, particularly the role of age at onset.
Yan Li, Ripsa Niemi, Mai Gutvilig, Marko Elovainio, Marjo Flykt, Christian Hakulinen   +5 more
wiley   +1 more source