Results 91 to 100 of about 63,057 (294)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression

Scientific Reports, 2017
Conventional cancer prevention has primarily focused on single chemopreventive compounds that may not be sufficiently efficacious. We sought to investigate potential combinatorial effects of epigenetic bioactive botanicals including epigallocatechin-3 ...
Yuan-Yuan Li, S. Meeran, T. Tollefsbol
semanticscholar   +1 more source

ERα-36 regulates progesterone receptor activity in breast cancer [PDF]

, 2020
: Background: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer (BC).
Poulard, Coralie, Omarjee, Soleilmane, Kassem, Loay, Konan, Henri-Philippe, Rezza, Amélie, Surmieliova-Garnès, Ausra, Le Romancer, Muriel, Jacquemetton, Julien, Cascales, Elodie, Treilleux, Isabelle, Trédan, Olivier   +10 more
core   +7 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets

Oncogene, 2018
Approximately 75% of breast cancers are estrogen receptor alpha (ERα)-positive and are treatable with endocrine therapies, but often patients develop lethal resistant disease.
Leah A. Gates, G. Gu, Yue Chen, A. Rohira, Jonathan T. Lei, Ross A. Hamilton, Yang Yu, D. Lonard, Jin Wang, Shu-Ping Wang, D. Edwards, P. Lavere, Jiangyong Shao, P. Yi, Antrix Jain, S. Jung, A. Malovannaya, Shun-Qiang Li, Jieya Shao, R. Roeder, M. Ellis, J. Qin, S. Fuqua, B. O'Malley, C. Foulds   +24 more
semanticscholar   +1 more source

GTPs and SFN synergistically reactivated ERα expression in ERα-negative human breast cancer cells.

, 2013
A) GTPs and SFN at indicated doses induced ERα re-expression in ERα-negative MDA-MB-231 human breast cancer cells after 72 h of post-treatments. B) Treatment with GTPs or SFN and a combination of both of the compounds at indicated doses induced ERα re ...
Samriddhi Shukla (321547), Shweta N. Patel (321544), Trygve O. Tollefsbol (104296), Yuanyuan Li (18671), Syed M. Meeran (321543)   +4 more
core   +1 more source

A modulator based regulatory network for ERα signaling pathway [PDF]

, 2012
Background: Estrogens control multiple functions of hormone-responsive breast cancer cells. They regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of gene ...
Guanglong Jiang, Nephew, Kenneth P., Huang, Tim H. M., Jiang, Guanglong, Lang Li, Liu, Yunlong, Kenneth P Nephew, Zheng, Pengyue, Pengyue Zheng, Yunlong Liu, Heng-Yi Wu, Wu, Heng-Yi, Li, Lang, Tim HM Huang   +13 more
core   +1 more source

TNFα Enhances Tamoxifen Sensitivity through Dissociation of ERα-p53-NCOR1 Complexes in ERα-Positive Breast Cancer

, 2021
Tamoxifen is widely used as a medication for estrogen receptor α (ERα)-positive breast cancer, despite the ~50% incidence of tamoxifen resistance. To overcome such resistance, combining tamoxifen with other agents is considered an effective approach ...
Sungmin Kwak, Ji-Hoon Jeong, Ji-Hye Song, Seung-Ho Park, Gi-Jun Sung, Hyo-Kyoung Choi, Jin-Taek Hwang, Min-Jeong Kong, Hyunhee Kim, Jangho Lee, Kyung-Chul Choi   +10 more
core   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

An estrogen receptor α-derived peptide improves glucose homeostasis during obesity

Nature Communications
Estrogen receptor α (ERα) plays a crucial role in regulating glucose and energy homeostasis during type 2 diabetes mellitus (T2DM). However, the underlying mechanisms remain incompletely understood.
Wanbao Yang, Wen Jiang, Wang Liao, Hui Yan, Weiqi Ai, Quan Pan, Wesley A. Brashear, Yong Xu, Ling He, Shaodong Guo   +9 more
doaj   +1 more source