Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
doaj +1 more source
Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]
, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille +12 more
core +2 more sources
A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]
, 2013 The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica +4 more
core +3 more sources
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]
, 2008 The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner +32 more
core +4 more sources
COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
iScience, 2023 Summary: Misfolded proteins and components of the endoplasmic reticulum (ER) quality control and ER associated degradation (ERAD) machineries concentrate in mammalian cells in the pericentriolar ER-derived quality control compartment (ERQC), suggesting ...
Navit Ogen-Shtern +6 more
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Deformation theory of representations of prop(erad)s [PDF]
, 2008 We study the deformation theory of morphisms of properads and props thereby extending to a non-linear framework Quillen's deformation theory for commutative rings. The associated chain complex is endowed with a Lie algebra up to homotopy structure.
Bruno Vallette +2 more
core +14 more sources
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core +2 more sources
Science, 2015 On 20 September 2015, the Global Commission for the Certification of Poliomyelitis Eradication (GCC) declared that type 2 wild poliovirus had been eradicated. The GCC examined reports from 189 of 195 countries around the world and studied separate data [held by the World Health Organization (WHO)] from the remaining countries.
Anthony, Adams, David M, Salisbury
openaire +2 more sources
Regulation of inner nuclear membrane associated protein degradation
Nucleus, 2019 The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a ...
Bailey Koch, Hong-Guo Yu
doaj +1 more source
Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation.
PLoS ONE, 2019 Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transport conduit.
Fabio Pereira +5 more
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