Results 31 to 40 of about 37,506 (169)

Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review

Pharmaceutics, 2020
While the success of dendritic cell (DC) vaccination largely depends on cross-presentation (CP) efficiency, the precise molecular mechanism of CP is not yet characterized.
Jun Imai, Sayaka Ohashi, Takahiro Sakai
doaj   +1 more source

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

Journal of Lipid Research, 2013
In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD).
Rebecca A. Faulkner, Andrew D. Nguyen, Youngah Jo, Russell A. DeBose-Boyd   +3 more
doaj   +1 more source

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]

, 2009
When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Richard S. Marshall, Nicholas A. Jolliffe, Aldo Ceriotti, Christopher J. Snowden, J. Michael Lord, Lorenzo Frigerio, Lynne M. Roberts, Vitale, Romisch, Meusser, Braun, Ye, Rabinovich, Jarosch, Ye, Rape, Lee, Worthington, Kothe, Feiler, Rancour, Muller, Di Cola, Di Cola, Tabe, Hellens, Frigerio, Pedrazzini, Hunter, Chaddock, Jolliffe, Roberts, Campbell, Maliga, Denecke, Klein, Martinez, Allen, Roberts, Wojcik, Dalal, Simpson, Day, Tsai, Bays, Denic, Carvalho, Swanson, Deak, Schuberth, Richly, Yoshida, Yoshida, Wiertz, Brandizzi, Roberts, Lord, Deeks, Wahlman, Wojcik, Carlson, Vashist, Vashist, Caldwell, Schmid, Kirst, Smalle, Carter, Contento, Pimpl   +69 more
core   +1 more source

The H protein of attenuated canine distemper virus is degraded via endoplasmic reticulum-associated protein degradation

Frontiers in Veterinary Science, 2023
Canine distemper (CD) caused by canine distemper virus (CDV) is considered a highly contagious and acutely febrile disease in various animals around the world.
Wenjie Wang, Wenjie Wang, Zhenwei Bi, Yakun Liu, Xingxia Xia, Jing Qian, Yeping Tan, Jianjun Zhao, Suquan Song   +8 more
doaj   +1 more source

Non-Abelian energy loss in cold nuclear matter [PDF]

, 2007
We use a formal recurrence relation approach to multiple parton scattering to find the complete solution to the problem of medium-induced gluon emission from partons propagating in cold nuclear matter.
A. Kovner, Ivan Vitev, J. D. Jackson, L. D. Landau, M. Gyulassy   +4 more
core   +2 more sources

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. [PDF]

PLoS ONE, 2012
Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes a cellular condition called ER stress. To overcome ER stress, unfolded proteins are eliminated by an ER-associated degradation (ERAD) system.
Yuka Eura, Hiroji Yanamoto, Yuji Arai, Tomohiko Okuda, Toshiyuki Miyata, Koichi Kokame   +5 more
doaj   +1 more source

Role of endoplasmic-reticulum-associated protein degradation pathway in the virus infection cycle

Journal of Education, Health and Sport, 2017
Introduction: The endoplasmic-reticulum-associated protein degradation (ERAD) pathway plays an important role in maintaining intracellular homeostasis and primarily affects proteins that have not achieved correct post-translational conformation.
Tomasz Wandtke, Ewelina Wędrowska, Arkadiusz Goede, Paulina Owczarska, Elżbieta Piskorska, Piotr Kopiński   +5 more
doaj   +3 more sources

Resonant structure of space-time of early universe [PDF]

, 2010
A new fully quantum method describing penetration of packet from internal well outside with its tunneling through the barrier of arbitrary shape used in problems of quantum cosmology, is presented.
A. Anderson, A. Garcia, A. Kobakhidze, A. Sobiczewski, A. Vilenkin, A. Vilenkin, A. Vilenkin, A. Vilenkin, A. Vilenkin, A. Vilenkin, A.A. Starobinsky, A.A. Starobinsky, A.D. Linde, A.D. Linde, A.D. Linde, A.D. Linde, A.V. Yurov, A.Y. Kamenshchik, B. Buck, B. Buck, B.S. DeWitt, C. Bastos, D. Bertacca, D. Levkov, D.N. Page, E. Carugno, E.M. Lifshitz, E.M. Lifshitz, F. Cardone, G.A. Monerat, I.G. Moss, J. Acacio de Barros, J. Garriga, J. Hong, J. Lu, J.A. Wheeler, J.B. Hartle, J.H. Fermor, K.W. McVoy, M. Bouhmadi-López, M. Bouhmadi-López, M. Bouhmadi-López, M. Bouhmadi-López, M. Bouhmadi-López, P. Ginsparg, P.J.E. Peebles, R. Brout, R. Brustein, R. Casadio, R. Casadio, S. Chaplygin, S. Esposito, S. Lee, S. Lee, S. Weinberg, S. Åberg, S.A. Gurvitz, S.A. Gurvitz, S.P. Kim, S.P. Maydanyuk, S.P. Maydanyuk, S.P. Maydanyuk, S.P. Maydanyuk, S.P. Maydanyuk, V. Yu. Denisov, V. Yu. Denisov, V.S. Olkhovsky, Ya.B. Zeldovich   +67 more
core   +1 more source

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. [PDF]

PLoS ONE, 2010
Huntington's disease (HD) is caused by polyglutamine expansion in huntingtin (htt) protein, but the exact mechanism of HD pathogenesis remains uncertain.
Hui Yang, Chao Liu, Yongwang Zhong, Shouqing Luo, Mervyn J Monteiro, Shengyun Fang   +5 more
doaj   +1 more source

Ab initio simulations of accretion disks instability [PDF]

, 2003
We show that accretion disks, both in the subcritical and supercritical accretion rate regime, may exhibit significant amplitude luminosity oscillations.
Molteni, D., Teresi, V., Toscano, E.
core   +2 more sources