Results 71 to 80 of about 37,506 (169)
Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland
JCI Insight, 2023 Defects in endoplasmic reticulum (ER) proteostasis have been linked to diseases in multiple organ systems. Here we examined the impact of perturbation of ER proteostasis in mice bearing thyrocyte-specific knockout of either HRD1 (to disable ER-associated
Xiaohan Zhang +11 more
doaj +1 more source
, 2010 Ultrarelativistic collisions of black holes are ideal gedanken experiments to study the nonlinearities of general relativity. In this paper we use semianalytical tools to better understand the nature of these collisions and the emitted gravitational ...
C. W. Misner +13 more
core +2 more sources
Test bodies and naked singularities: is the self-force the cosmic censor?
, 2010 Jacobson and Sotiriou showed that rotating black holes could be spun-up past the extremal limit by the capture of non-spinning test bodies, if one neglects radiative and self-force effects.
Barausse, Enrico +2 more
core +1 more source
ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction
EMBO ReportsThe endoplasmic reticulum (ER) produces proteins destined to organelles of the endocytic and secretory pathways, the plasma membrane, and the extracellular space.
Elisa Fasana +4 more
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EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog.
PLoS ONE, 2014 Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes. In S. cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local ...
Hsiang-Yun Tang +4 more
doaj +1 more source
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation
eLife, 2014 Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD).
Yanfen Liu +6 more
doaj +1 more source
Annals of Internal Medicine, 1961 Excerpt Poliomyelitis, as well as many other infectious diseases, probably began their association with the human species long before human beings evolved in their present form.
openaire +5 more sources
Radiation from low-momentum zoom-whirl orbits
, 2010 We study zoom-whirl behaviour of equal mass, non-spinning black hole binaries in full general relativity. The magnitude of the linear momentum of the initial data is fixed to that of a quasi-circular orbit, and its direction is varied.
B Brügmann +6 more
core +1 more source
Frontiers in Microbiology, 2019 Hepatitis B virus (HBV) belongs to the Hepadnaviridae family of enveloped DNA viruses. Recent studies have found that host factors can suppress HBV replication.
Jinyu Wang +11 more
doaj +1 more source