Results 171 to 180 of about 5,215 (208)

ERAP1 as an emerging therapeutic target for medulloblastoma

Trends in Cancer, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB).
Bufalieri F., Fruci D., Di Marcotullio L.   +2 more
openaire   +2 more sources

ERAP1 shapes just part of the immunopeptidome

Human Immunology, 2019
ERAP1 is an aminopeptidase involved in trimming long peptides to the lengths required for presentation by MHC class I. ERAP1 substrate preference is for peptides with hydrophobic or aliphatic N-terminal amino acids, with lower efficacy with charged and small hydrophilic amino acids and almost complete inefficiency with proline.
Arie Admon
exaly   +3 more sources

ERAP1: a potential therapeutic target for a myriad of diseases

Expert Opinion on Therapeutic Targets, 2020
Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells and NK cells. Studies have highlighted the essential requirement for the generation of stable peptide MHC I in regulating both innate and adaptive immune responses
Edward James
exaly   +4 more sources

THU0364 Rare Erap1 Allotype Combinations Do Not Explain The ERAP1 Association with Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2016
Background Single nucleotide polymorphisms (SNPs) in ERAP1 are strongly associated with ankylosing spondylitis (AS) (1,2). ERAP1 is an aminopeptidase involved in the generation of optimal peptide epitopes for presentation by T-cells in the context of major histocompatibility complex (MHC) class I molecules such as HLA-B27.
Appleton, LH, Roberts, AR, Vecellio, M, Wordsworth, BP   +3 more
openaire   +2 more sources

ERAP1 in the pathogenesis of ankylosing spondylitis

Immunologic Research, 2014
The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within ERAP1 as being ...
Reeves, Emma, Elliott, Tim, James, Edward, Edwards, Christopher J.   +3 more
openaire   +3 more sources

Polymorphisms in ERAP1 gene are associated with psoriasis

Meta Gene, 2022
Abstract Background Several polymorphisms in ERAP1 gene has been reported to be associated with psoriasis in several different populations. Objective To better understand the association between ERAP1 and psoriasis in Chinese Han population. Methods Seven SNPs (rs27044, rs27043, rs26510, rs469758, rs30378, rs30186 and rs2303208) in ERAP1 ...
Weiwei Chen, Liang Yong, Huiyao Ge, Qiongqiong Xu, Qi Zhen, Bao Li, Yafen Yu, Jing Wu, Xiaodong Zheng, Jinping Gao, Bo Liang, Hui Cheng, Liangdan Sun, Wenjun Wang   +13 more
openaire   +1 more source

The role of ERAP1 in autoinflammation and autoimmunity

Human Immunology, 2019
Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of disease involve abnormal immune activation of both the innate and adaptive immune systems. While both classes of disease represent a spectrum of aberrant immune activation, excessive activation of the innate immune system has been considered causal for the inflammation
Yuliya Pepelyayeva, Andrea Amalfitano
openaire   +2 more sources

Investigating the genetic association between ERAP1 and spondyloarthritis

Annals of the Rheumatic Diseases, 2013
A robust association between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations was recently identified. The aim of the current study was to determine the level of association of ERAP1 polymorphisms with spondyloarthritis (SpA) in French/Belgian populations with particular ...
Amir, Kadi, Brigitte, Izac, Roula, Said-Nahal, Ariane, Leboime, Liesbet, Van Praet, Kurt, de Vlam, Dirk, Elewaut, Gilles, Chiocchia, Maxime, Breban   +8 more
openaire   +2 more sources

ERAP1Is Associated with Ankylosing Spondylitis in Han Chinese

The Journal of Rheumatology, 2010
Objective.Genetic components play important roles in the incidence and development of ankylosing spondylitis (AS). Aminopeptidase regulator of tumor necrosis factor receptor shedding 1 (ERAP1) was recently found to be associated with AS in North American and British cohorts.
Chao, Li, Zhiming, Lin, Yingying, Xie, Zishi, Guo, Jinxian, Huang, Qiujing, Wei, Qiu Xia, Li, Xinwei, Wang, Shuangyan, Cao, Zetao, Liao, Manlong, Xu, Yan, Shen, Jieruo, Gu   +12 more
openaire   +2 more sources

FRI0195 ERAP1 Allotypes and Disease Severity in Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2015
Background ERAP1 trims peptides to the correct length to fit into the binding groove of MHC class I allowing antigen presentation. The association of ERAP1 with Ankylosing Spondylitis (AS) has been confirmed in a number of studies in both Caucasian and Asian cohorts, and requires the presence of HLA-B27.
W. Fong, E. Reeves, W. Tim, T. Elliot, E. James, C.J. Edwards   +5 more
openaire   +1 more source