Results 161 to 170 of about 3,350 (175)

ERAP1Is Associated with Ankylosing Spondylitis in Han Chinese

The Journal of Rheumatology, 2010
Objective.Genetic components play important roles in the incidence and development of ankylosing spondylitis (AS). Aminopeptidase regulator of tumor necrosis factor receptor shedding 1 (ERAP1) was recently found to be associated with AS in North American and British cohorts.
Chao, Li, Zhiming, Lin, Yingying, Xie, Zishi, Guo, Jinxian, Huang, Qiujing, Wei, Qiu Xia, Li, Xinwei, Wang, Shuangyan, Cao, Zetao, Liao, Manlong, Xu, Yan, Shen, Jieruo, Gu   +12 more
openaire   +2 more sources

A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population

Rheumatology International, 2013
We assessed the role played by the ERAP1 gene in Turkish patients with ankylosing spondylitis (AS) in terms of disease susceptibility, clinical manifestations, and disease severity. We included 150 consecutive AS patients who met the modified New York classification criteria and 150 healthy controls.
Muhammet, Cinar, Hatice, Akar, Sedat, Yilmaz, Ismail, Simsek, Mutlu, Karkucak, Rahsan Ilıkci, Sagkan, Aysel, Pekel, Hakan, Erdem, Ismail Yasar, Avci, Cengizhan, Acikel, Ugur, Musabak, Yusuf, Tunca, Salih, Pay   +12 more
openaire   +2 more sources

ERAP1 and the return of the UPR in ankylosing spondylitis

Nature Reviews Rheumatology, 2023
Nigil Haroon, Robert D. Inman
openaire   +2 more sources

Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population

Gene, 2018
To explore the association between five polymorphisms in endoplasmic reticulum associated aminopeptidase 1 (ERAP1) gene and risk of ankylosing spondylitis (AS) in a Chinese population. A case-control study enrolled 250 AS patients and 250 healthy controls was carried out.
Yin, Tang, Ping, Yang, Fang, Wang, Hui, Xu, Shou-Yang, Zong   +4 more
openaire   +2 more sources

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients

Human Immunology, 2019
The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
Andrzej, Wiśniewski, Sara, Kasprzyk, Edyta, Majorczyk, Izabela, Nowak, Karolina, Wilczyńska, Arkadiusz, Chlebicki, Aleksandra, Zoń-Giebel, Piotr, Kuśnierczyk   +7 more
openaire   +3 more sources

ERAP1 and MHC Class I Antigen Presentation

2004
Cytotoxic T lymphocytes (CTLs) are the principal mediators of immune responses against intracellular pathogens or tumors and recognize on the surface of target cells peptide fragments derived from foreign protein antigens bound to major histocompatibility complex (MHC) class I molecules.
Tomo Saric, Alfred L. Goldberg
openaire   +1 more source

ERAMER: A novel in silico tool for prediction of ERAP1 enzyme trimming

Journal of Immunological Methods
MHC class I pathway consists of four main steps: proteasomal cleavage in the cytosol in which precursor proteins are cleaved into smaller peptides, which are then transported into the endoplasmic reticulum by the transporter associated with antigen processing, TAP, for further processing (trimming) from the N-terminal region by an ER resident ...
Anas, Al-Okaily, Razan, Abu Khashabeh, Osama, Alsmadi, Yazan, Ahmad, Iyad, Sultan, Abdelghani, Tbakhi, Pramod K, Srivastava   +6 more
openaire   +2 more sources

ERAP1 modulators

2021
QUIBELL MARTIN, SPARENBERG MICHAEL, SHIERS JASON JOHN   +2 more
openaire   +3 more sources

INVESTIGATIONS INTO THE IMMUNOMODULATORY PROPERTIES OF SLAMF7 AND ERAP1

2021
openaire   +1 more source

Roles of ERAP1 and PPARץ in the development of arthritis

2013
Mestrado em ...
openaire   +1 more source