Results 151 to 160 of about 3,350 (175)

ERAP1 as an emerging therapeutic target for medulloblastoma

Trends in Cancer, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB).
Bufalieri F., Fruci D., Di Marcotullio L.   +2 more
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ERAP1 in the pathogenesis of ankylosing spondylitis

Immunologic Research, 2014
The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within ERAP1 as being ...
Reeves, Emma, Elliott, Tim, James, Edward, Edwards, Christopher J.   +3 more
openaire   +4 more sources

ERAP1 in ankylosing spondylitis

Current Opinion in Rheumatology, 2013
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex class I molecules. Natural ERAP1 polymorphism resulting in altered enzymatic activity is associated with ankylosing spondylitis, an inflammatory disorder ...
Álvarez-Navarro, Carlos, López de Castro, José A.   +1 more
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ERAP1 molecular characterization: Identification of a de novo allelic variant

HLA, 2018
The novel ERAP1 allelic variant is a missense polymorphism leading to the Arg53Pro substitution.
M. C. Padula, P. Leccese, A. A. Padula, S. D'Angelo, G. Martelli   +4 more
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Role of ERAP1 in antigen-presentation and ankylosing spondylitis

, 2017
Ankylosing spondylitis (AS) is a crippling autoimmune disorder that causes inflammation, fusion of the spinal vertebrae and osteoporosis. Over 40 years ago the strong association of AS to the HLA-B gene was discovered, but the pathogenesis of the disease
Rastall, David Patric Werner
openaire   +2 more sources

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The role of ERAP1 in autoinflammation and autoimmunity

Human Immunology, 2019
Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of disease involve abnormal immune activation of both the innate and adaptive immune systems. While both classes of disease represent a spectrum of aberrant immune activation, excessive activation of the innate immune system has been considered causal for the inflammation
Yuliya Pepelyayeva, Andrea Amalfitano
openaire   +2 more sources

THU0364 Rare Erap1 Allotype Combinations Do Not Explain The ERAP1 Association with Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2016
Background Single nucleotide polymorphisms (SNPs) in ERAP1 are strongly associated with ankylosing spondylitis (AS) (1,2). ERAP1 is an aminopeptidase involved in the generation of optimal peptide epitopes for presentation by T-cells in the context of major histocompatibility complex (MHC) class I molecules such as HLA-B27.
Appleton, LH, Roberts, AR, Vecellio, M, Wordsworth, BP   +3 more
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Polymorphisms in ERAP1 gene are associated with psoriasis

Meta Gene, 2022
Abstract Background Several polymorphisms in ERAP1 gene has been reported to be associated with psoriasis in several different populations. Objective To better understand the association between ERAP1 and psoriasis in Chinese Han population. Methods Seven SNPs (rs27044, rs27043, rs26510, rs469758, rs30378, rs30186 and rs2303208) in ERAP1 ...
Weiwei Chen, Liang Yong, Huiyao Ge, Qiongqiong Xu, Qi Zhen, Bao Li, Yafen Yu, Jing Wu, Xiaodong Zheng, Jinping Gao, Bo Liang, Hui Cheng, Liangdan Sun, Wenjun Wang   +13 more
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ERAP1 shapes just part of the immunopeptidome

Human Immunology, 2019
ERAP1 is an aminopeptidase involved in trimming long peptides to the lengths required for presentation by MHC class I. ERAP1 substrate preference is for peptides with hydrophobic or aliphatic N-terminal amino acids, with lower efficacy with charged and small hydrophilic amino acids and almost complete inefficiency with proline.
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Investigating the genetic association between ERAP1 and spondyloarthritis

Annals of the Rheumatic Diseases, 2013
A robust association between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations was recently identified. The aim of the current study was to determine the level of association of ERAP1 polymorphisms with spondyloarthritis (SpA) in French/Belgian populations with particular ...
Amir, Kadi, Brigitte, Izac, Roula, Said-Nahal, Ariane, Leboime, Liesbet, Van Praet, Kurt, de Vlam, Dirk, Elewaut, Gilles, Chiocchia, Maxime, Breban   +8 more
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