Results 201 to 210 of about 6,026 (227)

ERAP1 molecular characterization: Identification of a de novo allelic variant

HLA, 2018
The novel ERAP1 allelic variant is a missense polymorphism leading to the Arg53Pro substitution.
M. C. Padula, P. Leccese, A. A. Padula, S. D'Angelo, G. Martelli   +4 more
openaire   +3 more sources

Utility of serum ERAP1 and ERAP2 as novel biomarkers in the management of recalcitrant warts: A cross-sectional study.

Indian Journal of Dermatology, Venereology and Leprology
Background The exact mechanisms underlying the eradication of the human papillomavirus (HPV) by cellular immunity remain obscure. Individuals with treatment-resistant warts frequently have immune deficiencies.
Ihab Younis, Nehad A Fouad, O. Ibrahim, Karem T Khalil   +3 more
semanticscholar   +1 more source

ERAP1 deficiency protects HLA-B27 transgenic rats from arthritis

The Journal of Immunology, 2016
Abstract HLA-B27 (B27) confers a strong predisposition to spondyloarthritis (SpA). Rats transgenic for B27 (B27-TG) develop SpA-like disease with gut inflammation and arthritis. Common variants in ERAP1, which trims peptides for HLA class I in the ER, have been associated with SpA.
Tri M Tran, Tejpal Gill, Sohee Hong, Joshua Bennett, Robert A Colbert   +4 more
openaire   +1 more source

Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

Inflammation Research, 2011
The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS).The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility ...
Young Ho, Lee, Sung Jae, Choi, Jong Dae, Ji, Gwan Gyu, Song   +3 more
openaire   +2 more sources

ERAP1 and ERAP2 Gene Variants as Potential Clinical Biomarkers of Anti-IL-17A Response in Psoriasis Vulgaris.

Clincal and Experimental Dermatology
BACKGROUND Interleukin-17A (IL-17A) is a proinflammatory cytokine, playing an essential role in the development of psoriasis. Although treatment with anti-IL-17A monoclonal antibodies has demonstrated high efficacy in psoriasis patients, not all patients
Lasse Kronborg, Emma Oxlund Hansen, T. Bertelsen, A. H. Rittig, T. Emmanuel, Sofie Jørgensen, K. F. Hjuler, Lars Iversen, C. Johansen   +8 more
semanticscholar   +1 more source

AB0004 Erap1 Polymorphisms in Korean Patients with Behcet's Disease

Annals of the Rheumatic Diseases, 2014
Background Non-synonymous ERAP1 single nucleotide polymorphisms (SNPs), rs10050860 and rs17482078, were found to be associated with Behcet9s disease (BD) by a recessive model in Turkish patients [1]. Objectives To investigate the association between ERAP1 SNPs and BD in Korean patients.
E.H. Kang, S. Kim, C. Kang, Y.-M. Kang, S.W. Kang, H.J. Baek, E.Y. Lee, Y.J. Lee, E.B. Lee, Y.W. Song   +9 more
openaire   +1 more source

Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation.

Journal of Agricultural and Food Chemistry
ERAP1 is an emerging target for a large subclass of severe autoimmune diseases known as "MHC-I-opathy", together with tumor immunity. Nevertheless, effective inhibitors targeting ERAP1 remain a challenge.
Jiaqi Wu, Zhaohua Li, Xiaofan Liu, Dongyan Feng, Rui Liang, Xin Su, Dahong Li, Huiming Hua, Hao Cao   +8 more
semanticscholar   +1 more source

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients

Human Immunology, 2019
The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
Andrzej, Wiśniewski, Sara, Kasprzyk, Edyta, Majorczyk, Izabela, Nowak, Karolina, Wilczyńska, Arkadiusz, Chlebicki, Aleksandra, Zoń-Giebel, Piotr, Kuśnierczyk   +7 more
openaire   +3 more sources

Abstract LB367: Effects of modulation of ERAP1 activity in antigen processing and presentation

Cancer Research
ERAP1 is an enzyme that plays a key role in the antigen processing and presentation pathway as an editor of the peptide repertoire, allowing for the binding of neoantigens to MHC I.
Shami Alvarez Mourid, E. James, D. Guglietta, E. Reeves   +3 more
semanticscholar   +1 more source

MOLECULAR TYPING OF HLA-B*27 SUB-ALLELES REVEALS AN ASSOCIATION WITH ERAP1 AND DISEASE SUBSET OF ANKYLOSING SPONDYLITIS IN NORTH-INDIAN (KASHMIR) POPULATION

International Journal of Advanced Research
Background: Human Leukocyte Antigen(HLA)-B*27 is significantly linked to Ankylosing spondylitis(AS) and its presence aids in the diagnosis of the disease.
Nasi Ismail, Zafar A. Shah, Muneer Ahmad Baba, Fayaz A. Kanjwal, Nahidah Majid, Rabia Rakhshan, Muzaffar Ahmad Bindroo, S. Ayub   +7 more
semanticscholar   +1 more source