Results 181 to 190 of about 5,215 (208)

ERAP1 and MHC Class I Antigen Presentation

2004
Cytotoxic T lymphocytes (CTLs) are the principal mediators of immune responses against intracellular pathogens or tumors and recognize on the surface of target cells peptide fragments derived from foreign protein antigens bound to major histocompatibility complex (MHC) class I molecules.
Tomo Saric, Alfred L. Goldberg
openaire   +1 more source

ERAP1 molecular characterization: Identification of a de novo allelic variant

HLA, 2018
The novel ERAP1 allelic variant is a missense polymorphism leading to the Arg53Pro substitution.
M. C. Padula, P. Leccese, A. A. Padula, S. D'Angelo, G. Martelli   +4 more
openaire   +3 more sources

ERAP1 deficiency protects HLA-B27 transgenic rats from arthritis

The Journal of Immunology, 2016
Abstract HLA-B27 (B27) confers a strong predisposition to spondyloarthritis (SpA). Rats transgenic for B27 (B27-TG) develop SpA-like disease with gut inflammation and arthritis. Common variants in ERAP1, which trims peptides for HLA class I in the ER, have been associated with SpA.
Tri M Tran, Tejpal Gill, Sohee Hong, Joshua Bennett, Robert A Colbert   +4 more
openaire   +1 more source

Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

Inflammation Research, 2011
The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS).The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility ...
Young Ho, Lee, Sung Jae, Choi, Jong Dae, Ji, Gwan Gyu, Song   +3 more
openaire   +2 more sources

AB0004 Erap1 Polymorphisms in Korean Patients with Behcet's Disease

Annals of the Rheumatic Diseases, 2014
Background Non-synonymous ERAP1 single nucleotide polymorphisms (SNPs), rs10050860 and rs17482078, were found to be associated with Behcet9s disease (BD) by a recessive model in Turkish patients [1]. Objectives To investigate the association between ERAP1 SNPs and BD in Korean patients.
E.H. Kang, S. Kim, C. Kang, Y.-M. Kang, S.W. Kang, H.J. Baek, E.Y. Lee, Y.J. Lee, E.B. Lee, Y.W. Song   +9 more
openaire   +1 more source

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients

Human Immunology, 2019
The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
Andrzej, Wiśniewski, Sara, Kasprzyk, Edyta, Majorczyk, Izabela, Nowak, Karolina, Wilczyńska, Arkadiusz, Chlebicki, Aleksandra, Zoń-Giebel, Piotr, Kuśnierczyk   +7 more
openaire   +3 more sources

ERAMER: A novel in silico tool for prediction of ERAP1 enzyme trimming

Journal of Immunological Methods
MHC class I pathway consists of four main steps: proteasomal cleavage in the cytosol in which precursor proteins are cleaved into smaller peptides, which are then transported into the endoplasmic reticulum by the transporter associated with antigen processing, TAP, for further processing (trimming) from the N-terminal region by an ER resident ...
Anas, Al-Okaily, Razan, Abu Khashabeh, Osama, Alsmadi, Yazan, Ahmad, Iyad, Sultan, Abdelghani, Tbakhi, Pramod K, Srivastava   +6 more
openaire   +2 more sources

ERAP1 and the return of the UPR in ankylosing spondylitis

Nature Reviews Rheumatology, 2023
Nigil Haroon, Robert D. Inman
openaire   +2 more sources

ERAP1 Gen İfadesinin Plazma Hücre Diskrazilerinde İncelenmesi

İSTANBUL KANUNİ SULTAN SÜLEYMAN TIP DERGİSİ, 2022
openaire   +1 more source

Functional ERAP1 Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of HLA-B27 in Taiwanese

Cells, 2022
Jing-Chi Lin, Jianming Wu, Ji-Yih Chen
exaly