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Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Nature Structural and Molecular Biology, 2011
Shih-Chung Chang   +2 more
exaly  

ERAP1 modulation as an innovative strategy for cancer treatment

The recent development of immune checkpoint blockade (ICB)-mediated immunotherapy has achieved outstanding clinical results in patients with a broad spectrum of cancer types, improving their overall survival. Despite the encouraging results, the number of patients who can benefit and have a long-term response to treatment is limited.
openaire   +1 more source

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